Detail

UniProtKB-A8K2U0


Protein	Alpha-2-macroglobulin-like protein 1
Gene	A2ML1
Status	Reviewed
Source	Breast Cancer cell lines; Breast cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Ovarian tumor; Prostate; Prostate tumor; Saliva; Serum; Serum (HCC); Urine
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
104	VSGVGNnISFEEK	2007(52); 2012(unpublished);2007(unpublished);2007;
120	IIQRQGnGTFVQT	2013(37);
120	QGnGTFVQTDKPLYTPGQQVYFR	2007(52); 2012(unpublished);2015(unpublished);2007;2007;
281	nLSGQTDK	2015(unpublished);
281	CRnLSGQTDK	2013(38);
409	ETSGWnGTDVSLEGK	2007(unpublished);2007(unpublished);2007;
409	TLETSGWnGTDVSLEGK	2015(unpublished);
857	THHWnITAVK	2007(52); 2012(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007;2007;
857	AKTHHWnITAVKI	2013(37);
867	HInFTISTK	2007(unpublished);2007(unpublished);2007;
867	LGHInFTISTK	2015(unpublished);2015(unpublished);
867	VKIGHInFTISTK	2013(37);
1020	HSnGSYSAFGER	2007(56); 2011(14); 2014(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;2007;2007;
1020	IMYKHSnGSYSAF	2013(37);

Sequence

1	11	21	31	41	51	61	71	81	91
MWAQLLLGML	ALSPAIAEEL	PNYLVTLPAR	LNFPSVQKVC	LDLSPGYSDV	KFTVTLETKD	KTQKLLEYSG	LKKRHLHCIS	FLVPPPAGGT	EEVATIRVSG
101	111	121	131	141	151	161	171	181	191
VGNNISFEEK	KKVLIQRQGN	GTFVQTDKPL	YTPGQQVYFR	IVTMDSNFVP	VNDKYSMVEL	QDPNSNRIAQ	WLEVVPEQGI	VDLSFQLAPE	AMLGTYTVAV
201	211	221	231	241	251	261	271	281	291
AEGKTFGTFS	VEEYVLPKFK	VEVVEPKELS	TVQESFLVKI	CCRYTYGKPM	LGAVQVSVCQ	KANTYWYREV	EREQLPDKCR	NLSGQTDKTG	CFSAPVDMAT
301	311	321	331	341	351	361	371	381	391
FDLIGYAYSH	QINIVATVVE	EGTGVEANAT	QNIYISPQMG	SMTFEDTSNF	YHPNFPFSGK	IRVRGHDDSF	LKNHLVFLVI	YGTNGTFNQT	LVTDNNGLAP
401	411	421	431	441	451	461	471	481	491
FTLETSGWNG	TDVSLEGKFQ	MEDLVYNPEQ	VPRYYQNAYL	HLRPFYSTTR	SFLGIHRLNG	PLKCGQPQEV	LVDYYIDPAD	ASPDQEISFS	YYLIGKGSLV
501	511	521	531	541	551	561	571	581	591
MEGQKHLNSK	KKGLKASFSL	SLTFTSRLAP	DPSLVIYAIF	PSGGVVADKI	QFSVEMCFDN	QVSLGFSPSQ	QLPGAEVELQ	LQAAPGSLCA	LRAVDESVLL
601	611	621	631	641	651	661	671	681	691
LRPDRELSNR	SVYGMFPFWY	GHYPYQVAEY	DQCPVSGPWD	FPQPLIDPMP	QGHSSQRSII	WRPSFSEGTD	LFSFFRDVGL	KILSNAKIKK	PVDCSHRSPE
701	711	721	731	741	751	761	771	781	791
YSTAMGAGGG	HPEAFESSTP	LHQAEDSQVR	QYFPETWLWD	LFPIGNSGKE	AVHVTVPDAI	TEWKAMSFCT	SQSRGFGLSP	TVGLTAFKPF	FVDLTLPYSV
801	811	821	831	841	851	861	871	881	891
VRGESFRLTA	TIFNYLKDCI	RVQTDLAKSH	EYQLESWADS	QTSSCLCADD	AKTHHWNITA	VKLGHINFTI	STKILDSNEP	CGGQKGFVPQ	KGRSDTLIKP
901	911	921	931	941	951	961	971	981	991
VLVKPEGVLV	EKTHSSLLCP	KGKVASESVS	LELPVDIVPD	STKAYVTVLG	DIMGTALQNL	DGLVQMPSGC	GEQNMVLFAP	IIYVLQYLEK	AGLLTEEIRS
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
RAVGFLEIGY	QKELMYKHSN	GSYSAFGERD	GNGNTWLTAF	VTKCFGQAQK	FIFIDPKNIQ	DALKWMAGNQ	LPSGCYANVG	NLLHTAMKGG	VDDEVSLTAY
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
VTAALLEMGK	DVDDPMVSQG	LRCLKNSATS	TTNLYTQALL	AYIFSLAGEM	DIRNILLKQL	DQQAIISGES	IYWSQKPTPS	SNASPWSEPA	AVDVELTAYA
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
LLAQLTKPSL	TQKEIAKATS	IVAWLAKQHN	AYGGFSSTQD	TVVALQALAK	YATTAYMPSE	EINLVVKSTE	NFQRTFNIQS	VNRLVFQQDT	LPNVPGMYTL
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
EASGQGCVYV	QTVLRYNILP	PTNMKTFSLS	VEIGKARCEQ	PTSPRSLTLT	IHTSYVGSRS	SSNMAIVEVK	MLSGFSPMEG	TNQLLLQQPL	VKKVEFGTDT
1401	1411	1421	1431	1441	1451
LNIYLDELIK	NTQTYTFTIS	QSVLVTNLKP	ATIKVYDYYL	PDEQATIQYS	DPCE

Reference

ID	Publication
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38	Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
52	Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
56	Bandhakavi S, Van Riper SK, Tawfik PN, Stone MD, Haddad T, Rhodus NL, Carlis JV, Griffin TJ: Hexapeptide Libraries for Enhanced Protein PTM Identification and Relative Abundance Profiling in Whole Human Saliva. Journal of Proteome Research 2011, 10:1052-1061.