| Protein | Beta-mannosidase |
| Gene | MANBA |
| Status | Reviewed |
| Source | ARO Cell Line (Thyroid Cance); Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Prostate tumor; TPC-1 Cell Line (Thyroid Cance); Urine |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 77 | WVSIDnWTYSK | 2014(16); |
| 77 | WVSLDnWTYSK | 2009(62); 2009(62); 2012(52); 2013(40); 2014(33); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2007;2007; |
| 77 | WVSLDnWTYSKE | 2014(33); |
| 77 | RWVSIDnWTYSKE | 2013(37); |
| 280 | LFVnISK | 2014(33); |
| 280 | IVELFVnISK | 2012(52); 2014(33); 2015(unpublished);2015(2); 2015(unpublished);2015(unpublished);2015(unpublished); |
| 280 | IVEIFVnISKNIT | 2013(37); |
| 284 | IVEIFVNISKnIT | 2013(37); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MRLHLLLLLA | LCGAGTTAAE | LSYSLRGNWS | ICNGNGSLEL | PGAVPGCVHS | ALFQQGLIQD | SYYRFNDLNY | RWVSLDNWTY | SKEFKIPFEI | SKWQKVNLIL |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| EGVDTVSKIL | FNEVTIGETD | NMFNRYSFDI | TNVVRDVNSI | ELRFQSAVLY | AAQQSKAHTR | YQVPPDCPPL | VQKGECHVNF | VRKEQCSFSW | DWGPSFPTQG |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| IWKDVRIEAY | NICHLNYFTF | SPIYDKSAQE | WNLEIESTFD | VVSSKPVGGQ | VIVAIPKLQT | QQTYSIELQP | GKRIVELFVN | ISKNITVETW | WPHGHGNQTG |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| YNMTVLFELD | GGLNIEKSAK | VYFRTVELIE | EPIKGSPGLS | FYFKINGFPI | FLKGSNWIPA | DSFQDRVTSE | LLRLLLQSVV | DANMNTLRVW | GGGIYEQDEF |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| YELCDELGIM | VWQDFMFACA | LYPTDQGFLD | SVTAEVAYQI | KRLKSHPSII | IWSGNNENEE | ALMMNWYHIS | FTDRPIYIKD | YVTLYVKNIR | ELVLAGDKSR |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| PFITSSPTNG | AETVAEAWVS | QNPNSNYFGD | VHFYDYISDC | WNWKVFPKAR | FASEYGYQSW | PSFSTLEKVS | STEDWSFNSK | FSLHRQHHEG | GNKQMLYQAG |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| LHFKLPQSTD | PLRTFKDTIY | LTQVMQAQCV | KTETEFYRRS | RSEIVDQQGH | TMGALYWQLN | DIWQAPSWAS | LEYGGKWKML | HYFAQNFFAP | LLPVGFENEN |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| TFYIYGVSDL | HSDYSMTLSV | RVHTWSSLEP | VCSRVTERFV | MKGGEAVCLY | EEPVSELLRR | CGNCTRESCV | VSFYLSADHE | LLSPTNYHFL | SSPKEAVGLC |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | ||
| KAQITAIISQ | QGDIFVFDLE | TSAVAPFVWL | DVGSIPGRFS | DNGFLMTEKT | RTILFYPWEP | TSKNELEQSF | HVTSLTDIY |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |