Contains      

UniProtKB-O14773

Protein Tripeptidyl-peptidase 1
Gene TPP1
Status Reviewed
Source Breast cell lines; Colorectal cancer cell line, HCT-116 (colorectal cancer); DLBCL cell lines (Diffuse large B-cell lymphoma); DRO-1 Cell Line (Thyroid Cance); HEK293T cell line (embryonic kidney); HeLa cell line (Cervical cancer); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Platelet; Prostate; Prostate tumor; Serum; TPC-1 Cell Line (Thyroid Cance); Urine; XTC-1 Cell Line (Thyroid Cance)
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
210 nLTSQDVGSGTSNNSQ 2014(33);
210 YnITSQDVGSGTSNNS 2014(32);
210 nLTSQDVGSGTSNNSQA 2014(33);
210 YnLTSQDVGSGTSNNSQ 2014(33);
210 nLTSQDVGSGTSNNSQAC 2014(33);
210 RYnLTSQDVGSGTSNNSQ 2014(33);
210 YnLTSQDVGSGTSNNSQA 2012(48); 2014(14); 2014(33); 2015(unpublished);
210 RYnLTSQDVGSGTSNNSQA 2011(57); 2014(33);
210 YnLTSQDVGSGTSNNSQAC 2012(48);
210 KRYnLTSQDVGSGTSNNSQA 2007(unpublished);2007(unpublished);2014(33);
210 nLTSQDVGSGTSNNSQACAQ 2014(33);
210 YnLTSQDVGSGTSNNSQACA 2014(14); 2015(unpublished);
210 nLTSQDVGSGTSNNSQACAQF 2014(33);
210 YnLTSQDVGSGTSNNSQACAQ 2014(33);
210 YnLTSQDVGSGTSNNSQACAQF 2014(33);
210 RYnLTSQDVGSGTSNNSQACAQF 2014(33);
210 YnLTSQDVGSGTSNNSQACAQFLE 2014(33);
210 RYnLTSQDVGSGTSNNSQACAQFLE 2014(33);
210 KRYnLTSQDVGSGTSNNSQACAQFLE 2014(33);
210 YnLTSQDVGSGTSNNSQACAQFLEQY 2014(33);
210 YnLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQF 2014(33);
210 YnITSQDVGSGTSNNSQACAQFIEQYFHDSDIAQFMR 2014(16); 2014(32);
210 YnLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMR 2009(62); 2009(62); 2009(62); 2009(64); 2009(67); 2011(58); 2012(52); 2013(34); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);2015(2); 2015(unpublished);
210 RYnLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMR 2012(52); 2015(unpublished);
210 KRYnITSQDVGSGTSNNSQACAQFIEQYFHDSDIAQFMR 2014(16);
210 KRYnLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMR 2012(52);
222 NLTSQDVGSGTSnNSQ 2014(33);
222 YNITSQDVGSGTSnNS 2014(32);
222 LTSQDVGSGTSnNSQAC 2009(64);
222 NLTSQDVGSGTSnNSQA 2014(33);
222 YNLTSQDVGSGTSnNSQ 2014(33);
222 NLTSQDVGSGTSnNSQAC 2014(33);
222 RYNLTSQDVGSGTSnNSQ 2014(33);
222 YNLTSQDVGSGTSnNSQA 2012(48); 2014(14); 2014(33); 2015(unpublished);
222 RYNLTSQDVGSGTSnNSQA 2011(57); 2014(33);
222 TSQDVGSGTSnNSQACAQF 2014(33);
222 YNLTSQDVGSGTSnNSQAC 2012(48);
222 KRYNLTSQDVGSGTSnNSQA 2007(unpublished);2007(unpublished);2014(33);
222 NLTSQDVGSGTSnNSQACAQ 2014(33);
222 YNLTSQDVGSGTSnNSQACA 2014(14); 2015(unpublished);
222 NLTSQDVGSGTSnNSQACAQF 2014(33);
222 YNLTSQDVGSGTSnNSQACAQ 2014(33);
222 YNLTSQDVGSGTSnNSQACAQF 2014(33);
222 RYNLTSQDVGSGTSnNSQACAQF 2014(33);
222 YNLTSQDVGSGTSnNSQACAQFLE 2014(33);
222 RYNLTSQDVGSGTSnNSQACAQFLE 2014(33);
222 KRYNLTSQDVGSGTSnNSQACAQFLE 2014(33);
222 YNLTSQDVGSGTSnNSQACAQFLEQY 2014(33);
222 YNLTSQDVGSGTSnNSQACAQFLEQYFHDSDLAQF 2014(33);
222 YNITSQDVGSGTSnNSQACAQFIEQYFHDSDIAQFMR 2014(16); 2014(32);
222 YNLTSQDVGSGTSnNSQACAQFLEQYFHDSDLAQFMR 2009(62); 2009(62); 2009(62); 2009(64); 2009(67); 2011(58); 2012(52); 2013(34); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);2015(2); 2015(unpublished);
222 RYNLTSQDVGSGTSnNSQACAQFLEQYFHDSDLAQFMR 2012(52); 2015(unpublished);
222 KRYNITSQDVGSGTSnNSQACAQFIEQYFHDSDIAQFMR 2014(16);
222 KRYNLTSQDVGSGTSnNSQACAQFLEQYFHDSDLAQFMR 2012(52);
286 SAGAnISTW 2014(33);
286 MSAGAnISTW 2014(33);
286 LMSAGAnISTW 2014(33);
286 SAGAnISTWVY 2014(33);
286 MSAGAnISTWVY 2014(33);
286 nISTWVYSSPGR 2015(1);
286 YLMSAGAnISTW 2014(33);
286 LMSAGAnISTWVY 2014(33);
286 VQYLMSAGAnISTW 2014(33);
286 SAGAnISTWVYSSPGR 2015(unpublished);
286 VQYLMSAGAnISTWVY 2014(33);
286 MSAGAnISTWVYSSPGR 2007(unpublished);2007(unpublished);2007;
286 AGIEASLDVQYLMSAGAnISTWVYSSPGR 2015(2);
313 LMLLSnES 2014(33);
313 SnESALPH 2014(33);
313 WLMLLSnE 2014(33);
313 LSnESALPH 2009(64); 2014(33);
313 QWLMLLSnE 2014(33);
313 LLSnESALPH 2009(64); 2014(33);
313 LMLLSnESAL 2014(33);
313 SnESALPHVH 2014(33);
313 LMLLSnESALP 2014(33);
313 LSnESALPHVH 2014(33);
313 MLLSnESALPH 2014(33);
313 LLSnESALPHVH 2014(33);
313 LMLLSnESALPH 2014(33);
313 LMLLSnESALPHV 2014(33);
313 MLLSnESALPHVH 2014(33);
313 LMLLSnESALPHVH 2014(33);
313 QWLMLLSnESALPH 2014(33);
313 GQEPFLQWLMLLSnE 2014(33);
313 LQWLMLLSnESALPH 2014(33);
313 LLSnESALPHVHTVSY 2014(33);
313 HEGQEPFLQWLMLLSnE 2014(33);
313 LQWLMLLSnESALPHVH 2014(33);
313 HEGQEPFLQWLMLLSnESALPH 2014(33);
313 HEGQEPFLQWLMLLSnESALPHVH 2015(unpublished);
313 SnESALPHVHTVSYGDDEDSLSSAY 2014(33);
313 LLSnESALPHVHTVSYGDDEDSLSSAY 2014(33);
313 SSPGRHEGQEPFLQWLMLLSnESALPH 2014(33);
313 MLLSnESALPHVHTVSYGDDEDSLSSAY 2014(33);
313 SnESALPHVHTVSYGDDEDSLSSAYIQR 2014(33); 2015(unpublished);
313 LMLLSnESALPHVHTVSYGDDEDSLSSAY 2014(33);
313 LSnESALPHVHTVSYGDDEDSLSSAYIQR 2007(33); 2014(unpublished);2015(unpublished);2007;2007;
313 LLSnESALPHVHTVSYGDDEDSLSSAYIQR 2011(57); 2012(48); 2014(19); 2014(33); 2015(unpublished);
313 MLLSnESALPHVHTVSYGDDEDSLSSAYIQR 2012(48); 2014(33); 2015(unpublished);

Sequence

1112131415161718191
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLHTVQ
101111121131141151161171181191
KWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGV
201211221231241251261271281291
TPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEG
301311321331341351361371381391
QEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLIT
401411421431441451461471481491
NEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPL
501511521531541551561
GFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
19Huang G, Sun Z, Qin H, Zhao L, Xiong Z, Peng X, Ou J, Zou H: Preparation of hydrazine functionalized polymer brushes hybrid magnetic nanoparticles for highly specific enrichment of glycopeptides. Analyst 2014, 139:2199-2206.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
57Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
62Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
67McDonald CA, Yang JY, Marathe V, Yen T-Y, Macher BA: Combining Results from Lectin Affinity Chromatography and Glycocapture Approaches Substantially Improves the Coverage of the Glycoproteome. Molecular & Cellular Proteomics 2009, 8:287-301.