Contains      

UniProtKB-O15394

Protein Neural cell adhesion molecule 2
Gene NCAM2
Status Reviewed
Source 22Rv1 cell line (prostate cancer); Breast Cancer cell lines; Breast cell lines; Cerebrospinal fluid; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); LNCap/PC3 cell lines (Prostate cancer); Liver; LnCap cell line (Prostate cancer); OVCAR-3 cell line (Ovarian cancer); Prostate; Prostate cancer cell lines; Prostate tumor; Serum; Urine; plasma
Years 2003-2015

Glycosites

Site Identified Peptides Year(Publication ID)
177 ANNNLQILNInK 2007(unpublished);2007(unpublished);2007;
177 IQIINInKSDEGI 2013(37);
177 FAMLANNNLQILNInK 2012(52); 2013(45); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2015;2007;2007;
177 FAMIANNNIQIINInKSDEGIYR 2014(16);
177 FAMLANNNLQILNInKSDEGIYR 2012(52);
177 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNInK 2012(52);
219 SFnATAER 2012(50); 2012(52); 2014(14); 2014(22); 2014(33); 2015(2); 2015(10);
219 MPQKSFnATAERG 2013(37);
219 SFnATAERGEEMTFSCR 2012(52); 2014(16);
309 nETTYENGQVTLVCDAEGEPIPEITWK 2015(2);
406 FISnQTIYYSWE 2014(33);
406 FISnQTIYYSWEGNPINISCDVK 2012(50); 2012(52); 2015(2);
419 GNPInISCDVK 2014(33);
419 SWEGNPInISCDVK 2014(33);
419 FISNQTIYYSWEGNPInISCDVK 2012(50); 2012(52); 2015(2);
445 nTTNLK 2015(2); 2015(10);
445 LVLPAKnTTNLK 2003( 83); 2015(2); 2007(unpublished);2007(unpublished);2007(unpublished);
445 IVIPAKnTTNIKT 2013(37);
445 DKIVIPAKnTTNIK 2014(16);
445 DKLVLPAKnTTNLK 2012(52); 2014(33); 2015(1); 2015(2);
474 YnCTATNHIGTR 2012(50); 2012(52); 2013(42); 2013(45); 2014(14); 2014(16); 2014(33); 2015(2); 2015(unpublished);2015;2015;2007;
474 NDFGRYnCTATNH 2013(37);
474 MIIEIAPTSDNDFGRYnCTATNHIGTR 2014(16);
474 MILEIAPTSDNDFGRYnCTATNHIGTR 2012(52);
562 SHGVQTMVVINNIEPnTTYEIR 2014(16);
562 SHGVQTMVVLNNLEPnTTYEIR 2003( 83); 2012(52); 2015(2); 2015(10); 2007(unpublished);2007(unpublished);

Sequence

1112131415161718191
MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKG
101111121131141151161171181191
QTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRD
201211221231241251261271281291
IIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
301311321331341351361371381391
QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYA
401411421431441451461471481491
PKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPY
501511521531541551561571581591
GVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
601611621631641651661671681691
GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLG
701711721731741751761771781791
LGAVIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEP
801811821831
EKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
50Whitmore TE, Peterson A, Holzman T, Eastham A, Amon L, McIntosh M, Ozinsky A, Nelson PS, Martin DB: Integrative Analysis of N-Linked Human Glycoproteomic Data Sets Reveals PTPRF Ectodomain as a Novel Plasma Biomarker Candidate for Prostate Cancer. Journal of Proteome Research 2012, 11:2653-2665.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.