Detail

UniProtKB-O43897


Protein	Tolloid-like protein 1
Gene	TLL1
Status	Reviewed
Source	Breast Cancer cell lines; HCC cell lines (Liver); LNCap/PC3 cell lines (Prostate cancer); Ovarian tumor; Pancreatic islets; Prostate tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
125	IGFGLEQnNTVK	2013(40);
125	GFGIEQnNTVKGK	2013(37);
169	IGGnFTGSQR	2012(48);
169	VIGGnFTGSQR	2012(48); 2015(unpublished);2007(unpublished);2007;
390	IVLnFTTMDLYK	2013(40); 2015(2);
390	GEKIVInFTTMDI	2013(37);
626	LnGTITTPGWPK	2013(40);
626	GIITKInGTITTP	2013(37);

Sequence

1	11	21	31	41	51	61	71	81	91
MGLGTLSPRM	LVWLVASGIV	FYGELWVCAG	LDYDYTFDGN	EEDKTETIDY	KDPCKAAVFW	GDIALDDEDL	NIFQIDRTID	LTQNPFGNLG	HTTGGLGDHA
101	111	121	131	141	151	161	171	181	191
MSKKRGALYQ	LIDRIRRIGF	GLEQNNTVKG	KVPLQFSGQN	EKNRVPRAAT	SRTERIWPGG	VIPYVIGGNF	TGSQRAMFKQ	AMRHWEKHTC	VTFIERSDEE
201	211	221	231	241	251	261	271	281	291
SYIVFTYRPC	GCCSYVGRRG	NGPQAISIGK	NCDKFGIVVH	ELGHVIGFWH	EHTRPDRDNH	VTIIRENIQP	GQEYNFLKME	PGEVNSLGER	YDFDSIMHYA
301	311	321	331	341	351	361	371	381	391
RNTFSRGMFL	DTILPSRDDN	GIRPAIGQRT	RLSKGDIAQA	RKLYRCPACG	ETLQESNGNL	SSPGFPNGYP	SYTHCIWRVS	VTPGEKIVLN	FTTMDLYKSS
401	411	421	431	441	451	461	471	481	491
LCWYDYIEVR	DGYWRKSPLL	GRFCGDKLPE	VLTSTDSRMW	IEFRSSSNWV	GKGFAAVYEA	ICGGEIRKNE	GQIQSPNYPD	DYRPMKECVW	KITVSESYHV
501	511	521	531	541	551	561	571	581	591
GLTFQSFEIE	RHDNCAYDYL	EVRDGTSENS	PLIGRFCGYD	KPEDIRSTSN	TLWMKFVSDG	TVNKAGFAAN	FFKEEDECAK	PDRGGCEQRC	LNTLGSYQCA
601	611	621	631	641	651	661	671	681	691
CEPGYELGPD	RRSCEAACGG	LLTKLNGTIT	TPGWPKEYPP	NKNCVWQVVA	PTQYRISVKF	EFFELEGNEV	CKYDYVEIWS	GLSSESKLHG	KFCGAEVPEV
701	711	721	731	741	751	761	771	781	791
ITSQFNNMRI	EFKSDNTVSK	KGFKAHFFSD	KDECSKDNGG	CQHECVNTMG	SYMCQCRNGF	VLHDNKHDCK	EAECEQKIHS	PSGLITSPNW	PDKYPSRKEC
801	811	821	831	841	851	861	871	881	891
TWEISATPGH	RIKLAFSEFE	IEQHQECAYD	HLEVFDGETE	KSPILGRLCG	NKIPDPLVAT	GNKMFVRFVS	DASVQRKGFQ	ATHSTECGGR	LKAESKPRDL
901	911	921	931	941	951	961	971	981	991
YSHAQFGDNN	YPGQVDCEWL	LVSERGSRLE	LSFQTFEVEE	EADCGYDYVE	LFDGLDSTAV	GLGRFCGSGP	PEEIYSIGDS	VLIHFHTDDT	INKKGFHIRY
1001	1011
KSIRYPDTTH	TKK

Reference

ID	Publication
2	Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.