Detail

UniProtKB-O60245


Protein	Protocadherin-7
Gene	PCDH7
Status	Reviewed
Source	Breast Cancer cell lines; Breast cancer xenografts; Colorectal tumor; HCC cell lines (Liver); HCCLM3 cell line (Liver); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; Urine
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
79	EYIKIDnITGEIS	2013(37);
79	IDnLTGELSTSER	2007(63); 2009(48); 2012(40); 2013(14); 2014(22); 2014(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
518	nNSLIVK	2015(1);
518	EFNVVIVAVDSGSPSLSSnNSLIVK	2015(unpublished);
780	nYSIVGGNPFK	2015(1);
822	LVVQVnDSGQPSQSTTTLVHVFVNESVSNATAIDSQIAR	2015(unpublished);
840	LVVQVNDSGQPSQSTTTLVHVFVnESVSNATAIDSQIAR	2015(unpublished);
845	nATAIDSQIAR	2015(1);
845	LVVQVNDSGQPSQSTTTLVHVFVNESVSnATAIDSQIAR	2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MLRMRTAGWA	RGWCLGCCLL	LPLSLSLAAA	KQLLRYRLAE	EGPADVRIGN	VASDLGIVTG	SGEVTFSLES	GSEYLKIDNL	TGELSTSERR	IDREKLPQCQ
101	111	121	131	141	151	161	171	181	191
MIFDENECFL	DFEVSVIGPS	QSWVDLFEGQ	VIVLDINDNT	PTFPSPVLTL	TVEENRPVGT	LYLLPTATDR	DFGRNGIERY	ELLQEPGGGG	SGGESRRAGA
201	211	221	231	241	251	261	271	281	291
ADSAPYPGGG	GNGASGGGSG	GSKRRLDASE	GGGGTNPGGR	SSVFELQVAD	TPDGEKQPQL	IVKGALDREQ	RDSYELTLRV	RDGGDPPRSS	QAILRVLITD
301	311	321	331	341	351	361	371	381	391
VNDNSPRFEK	SVYEADLAEN	SAPGTPILQL	RAADLDVGVN	GQIEYVFGAA	TESVRRLLRL	DETSGWLSVL	HRIDREEVNQ	LRFTVMARDR	GQPPKTDKAT
401	411	421	431	441	451	461	471	481	491
VVLNIKDEND	NVPSIEIRKI	GRIPLKDGVA	NVAEDVLVDT	PIALVQVSDR	DQGENGVVTC	TVVGDVPFQL	KPASDTEGDQ	NKKKYFLHTS	TPLDYEATRE
501	511	521	531	541	551	561	571	581	591
FNVVIVAVDS	GSPSLSSNNS	LIVKVGDTND	NPPMFGQSVV	EVYFPENNIP	GERVATVLAT	DADSGKNAEI	AYSLDSSVMG	IFAIDPDSGD	ILVNTVLDRE
601	611	621	631	641	651	661	671	681	691
QTDRYEFKVN	AKDKGIPVLQ	GSTTVIVQVA	DKNDNDPKFM	QDVFTFYVKE	NLQPNSPVGM	VTVMDADKGR	NAEMSLYIEE	NNNIFSIEND	TGTIYSTMSF
701	711	721	731	741	751	761	771	781	791
DREHQTTYTF	RVKAVDGGDP	PRSATATVSL	FVMDENDNAP	TVTLPKNISY	TLLPPSSNVR	TVVATVLATD	SDDGINADLN	YSIVGGNPFK	LFEIDPTSGV
801	811	821	831	841	851	861	871	881	891
VSLVGKLTQK	HYGLHRLVVQ	VNDSGQPSQS	TTTLVHVFVN	ESVSNATAID	SQIARSLHIP	LTQDIAGDPS	YEISKQRLSI	VIGVVAGIMT	VILIILIVVM
901	911	921	931	941	951	961	971	981	991
ARYCRSKNKN	GYEAGKKDHE	DFFTPQQHDK	SKKPKKDKKN	KKSKQPLYSS	IVTVEASKPN	GQRYDSVNEK	LSDSPSMGRY	RSVNGGPGSP	DLARHYKSSS
1001	1011	1021	1031	1041	1051	1061
PLPTVQLHPQ	SPTAGKKHQA	VQDLPPANTF	VGAGDNISIG	SDHCSEYSCQ	TNNKYSKQMR	LHPYITVFG

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
48	Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
63	Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672.