Contains      

UniProtKB-O60449

Protein Lymphocyte antigen 75
Gene LY75
Status Reviewed
Source Breast Cancer cell lines; Breast cancer xenografts; Breast cancer xenograftsPBMC Macrophage cells; Breast cell lines; Breast cell linesJurkat T cell line; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HuH-7 cell line (Liver); Jurkat T cell line; Liver; Lymphocytes; Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian cancer cell lines; Ovarian tumor; Pancreatic islets; Plasma; Platelet; Platelet Plasma membranes; Platelet Plasma membranesJurkat T cell line; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
135 DGHGTAISnASDVWK 2007(48); 2012(52); 2012(13); 2014(22); 2014(33); 2014(8); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2015;2007;2007;2007;
135 DGHGTAISnASDVWKK 2013(38);
135 IAIKDGHGTAISnASDVWK 2014(16);
135 LALKDGHGTAISnASDVWK 2015(unpublished);
345 KPInNTVEITDVWTYSDTR 2014(16);
345 KPLnNTVELTDVWTYSDTR 2015(unpublished);2015(unpublished);2015;2007;2007;
377 LLVnESNSW 2014(33);
377 CDAGWIPNNGFCYIIVnESNSWDKAHAK 2014(16);
529 GTNCnLTITSR 2014(33);
529 IYEDEVPFGTNCnITITSR 2014(16);
529 IYEDEVPFGTNCnLTITSR 2012(48); 2012(52); 2014(22); 2014(33); 2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;
865 IAnISGDGQK 2007(74); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2007;2007;
865 IAnISGDGQKWWIR 2014(16);
934 YnVSSIEK 2014(16);
934 YnVSSLEK 2007(74); 2014(13); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
934 KYnVSSLEK 2014(33);
934 ICEKYnVSSLEKY 2014(33);
1076 nFTSCSER 2015(1);
1076 nFTSCSERHF 2014(33);
1076 PFTGTWnFTSCSE 2013(37);
1076 SPFTGTWnFTSCSER 2014(13); 2014(16); 2014(18); 2014(33); 2015(unpublished);2015(unpublished);
1103 QTIQnASETVK 2014(16);
1103 QTLQnASETVK 2007(74); 2014(13); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
1103 SRQTIQnASETVK 2013(37);
1103 SRQTLQnASETVK 2015(unpublished);
1225 TVDCNDNQPGAICYYSGnETEK 2013(38); 2014(13); 2014(22); 2015(unpublished);2015(unpublished);
1225 TVDCNDNQPGAICYYSGnETEKEVKPVDSVK 2014(13); 2014(16);
1392 IEMVDYKEEYnTTLPQFMPYEDGIYSVIQK 2015(unpublished);
1535 CPAAKEnGSR 2014(16);
1593 ENNnITMR 2014(16); 2014(22); 2014(33); 2015(unpublished);
1593 LMRENNnITMR 2014(13);
1642 CSMLIASnETWK 2014(13); 2014(33); 2015(unpublished);
1642 CSMIIASnETWKK 2014(16);

Sequence

1112131415161718191
MRTGWATPRRPAGLLMLLFWFFDLAEPSGRAANDPFTIVHGNTGKCIKPVYGWIVADDCDETEDKLWKWVSQHRLFHLHSQKCLGLDITKSVNELRMFSC
101111121131141151161171181191
DSSAMLWWKCEHHSLYGAARYRLALKDGHGTAISNASDVWKKGGSEESLCDQPYHEIYTRDGNSYGRPCEFPFLIDGTWHHDCILDEDHSGPWCATTLNY
201211221231241251261271281291
EYDRKWGICLKPENGCEDNWEKNEQFGSCYQFNTQTALSWKEAYVSCQNQGADLLSINSAAELTYLKEKEGIAKIFWIGLNQLYSARGWEWSDHKPLNFL
301311321331341351361371381391
NWDPDRPSAPTIGGSSCARMDAESGLWQSFSCEAQLPYVCRKPLNNTVELTDVWTYSDTRCDAGWLPNNGFCYLLVNESNSWDKAHAKCKAFSSDLISIH
401411421431441451461471481491
SLADVEVVVTKLHNEDIKEEVWIGLKNINIPTLFQWSDGTEVTLTYWDENEPNVPYNKTPNCVSYLGELGQWKVQSCEEKLKYVCKRKGEKLNDASSDKM
501511521531541551561571581591
CPPDEGWKRHGETCYKIYEDEVPFGTNCNLTITSRFEQEYLNDLMKKYDKSLRKYFWTGLRDVDSCGEYNWATVGGRRRAVTFSNWNFLEPASPGGCVAM
601611621631641651661671681691
STGKSVGKWEVKDCRSFKALSICKKMSGPLGPEEASPKPDDPCPEGWQSFPASLSCYKVFHAERIVRKRNWEEAERFCQALGAHLSSFSHVDEIKEFLHF
701711721731741751761771781791
LTDQFSGQHWLWIGLNKRSPDLQGSWQWSDRTPVSTIIMPNEFQQDYDIRDCAAVKVFHRPWRRGWHFYDDREFIYLRPFACDTKLEWVCQIPKGRTPKT
801811821831841851861871881891
PDWYNPDRAGIHGPPLIIEGSEYWFVADLHLNYEEAVLYCASNHSFLATITSFVGLKAIKNKIANISGDGQKWWIRISEWPIDDHFTYSRYPWHRFPVTF
901911921931941951961971981991
GEECLYMSAKTWLIDLGKPTDCSTKLPFICEKYNVSSLEKYSPDSAAKVQCSEQWIPFQNKCFLKIKPVSLTFSQASDTCHSYGGTLPSVLSQIEQDFIT
1001101110211031104110511061107110811091
SLLPDMEATLWIGLRWTAYEKINKWTDNRELTYSNFHPLLVSGRLRIPENFFEEESRYHCALILNLQKSPFTGTWNFTSCSERHFVSLCQKYSEVKSRQT
1101111111211131114111511161117111811191
LQNASETVKYLNNLYKIIPKTLTWHSAKRECLKSNMQLVSITDPYQQAFLSVQALLHNSSLWIGLFSQDDELNFGWSDGKRLHFSRWAETNGQLEDCVVL
1201121112211231124112511261127112811291
DTDGFWKTVDCNDNQPGAICYYSGNETEKEVKPVDSVKCPSPVLNTPWIPFQNCCYNFIITKNRHMATTQDEVHTKCQKLNPKSHILSIRDEKENNFVLE
1301131113211331134113511361137113811391
QLLYFNYMASWVMLGITYRNKSLMWFDKTPLSYTHWRAGRPTIKNEKFLAGLSTDGFWDIQTFKVIEEAVYFHQHSILACKIEMVDYKEEYNTTLPQFMP
1401141114211431144114511461147114811491
YEDGIYSVIQKKVTWYEALNMCSQSGGHLASVHNQNGQLFLEDIVKRDGFPLWVGLSSHDGSESSFEWSDGSTFDYIPWKGQTSPGNCVLLDPKGTWKHE
1501151115211531154115511561157115811591
KCNSVKDGAICYKPTKSKKLSRLTYSSRCPAAKENGSRWIQYKGHCYKSDQALHSFSEAKKLCSKHDHSATIVSIKDEDENKFVSRLMRENNNITMRVWL
1601161116211631164116511661167116811691
GLSQHSVDQSWSWLDGSEVTFVKWENKSKSGVGRCSMLIASNETWKKVECEHGFGRVVCKVPLGPDYTAIAIIVATLSILVLMGGLIWFLFQRHRLHLAG
170117111721
FSSVRYAQGVNEDEIMLPSFHD

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
8Ma C, Zhang Q, Qu JY, Zhao XY, Li X, Liu YP, Wang PG: A precise approach in large scale core-fucosylated glycoprotein identification with low- and high-normalized collision energy. Journal of Proteomics 2015, 114:61-70.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
74Lewandrowski U, Zahedi RP, Moebius J, Walter U, Sickmann A: Enhanced N-glycosylation site analysis of Sialoglycopeptides by strong cation exchange prefractionation applied to platelet plasma membranes. Molecular & Cellular Proteomics 2007, 6:1933-1941.