Detail

UniProtKB-O75096


Protein	Low-density lipoprotein receptor-related protein 4
Gene	LRP4
Status	Reviewed
Source	Breast cancer xenografts; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HCC cell lines (Liver)Jurkat T cell line; HEK293 cell line (embryonic kidney); Hela cell line (cervical cancer); Jurkat T cell line; Liver; Ovarian tumor; Prostate; Prostate tumor; Urine
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
264	nCTTSMCTAEQFR	2013(40);
1077	MVSLDIPYFADVVVPInITMK	2014(33);
1415	ADInGSNMETVIGR	2014(16);
1415	ADLnGSNMETVIGR	2013(40); 2014(13); 2007(unpublished);2007(unpublished);
1415	RADInGSNMETVIGR	2014(16);
1415	RADLnGSNMETVIGR	2014(13); 2015(unpublished);2015(unpublished);2015(12);
1467	VIInNSIDEPR	2014(16);
1467	VLInNSLDEPR	2013(40); 2014(13); 2014(14); 2014(15); 2014(22); 2015(unpublished);2015(unpublished);2015;2007;2007;
1467	KVIInNSIDEPR	2014(16);
1467	KVLInNSLDEPR	2014(13);

Sequence

1	11	21	31	41	51	61	71	81	91
MRRQWGALLL	GALLCAHGLA	SSPECACGRS	HFTCAVSALG	ECTCIPAQWQ	CDGDNDCGDH	SDEDGCILPT	CSPLDFHCDN	GKCIRRSWVC	DGDNDCEDDS
101	111	121	131	141	151	161	171	181	191
DEQDCPPREC	EEDEFPCQNG	YCIRSLWHCD	GDNDCGDNSD	EQCDMRKCSD	KEFRCSDGSC	IAEHWYCDGD	TDCKDGSDEE	NCPSAVPAPP	CNLEEFQCAY
201	211	221	231	241	251	261	271	281	291
GRCILDIYHC	DGDDDCGDWS	DESDCSSHQP	CRSGEFMCDS	GLCINAGWRC	DGDADCDDQS	DERNCTTSMC	TAEQFRCHSG	RCVRLSWRCD	GEDDCADNSD
301	311	321	331	341	351	361	371	381	391
EENCENTGSP	QCALDQFLCW	NGRCIGQRKL	CNGVNDCGDN	SDESPQQNCR	PRTGEENCNV	NNGGCAQKCQ	MVRGAVQCTC	HTGYRLTEDG	HTCQDVNECA
401	411	421	431	441	451	461	471	481	491
EEGYCSQGCT	NSEGAFQCWC	ETGYELRPDR	RSCKALGPEP	VLLFANRIDI	RQVLPHRSEY	TLLLNNLENA	IALDFHHRRE	LVFWSDVTLD	RILRANLNGS
501	511	521	531	541	551	561	571	581	591
NVEEVVSTGL	ESPGGLAVDW	VHDKLYWTDS	GTSRIEVANL	DGAHRKVLLW	QNLEKPRAIA	LHPMEGTIYW	TDWGNTPRIE	ASSMDGSGRR	IIADTHLFWP
601	611	621	631	641	651	661	671	681	691
NGLTIDYAGR	RMYWVDAKHH	VIERANLDGS	HRKAVISQGL	PHPFAITVFE	DSLYWTDWHT	KSINSANKFT	GKNQEIIRNK	LHFPMDIHTL	HPQRQPAGKN
701	711	721	731	741	751	761	771	781	791
RCGDNNGGCT	HLCLPSGQNY	TCACPTGFRK	ISSHACAQSL	DKFLLFARRM	DIRRISFDTE	DLSDDVIPLA	DVRSAVALDW	DSRDDHVYWT	DVSTDTISRA
801	811	821	831	841	851	861	871	881	891
KWDGTGQEVV	VDTSLESPAG	LAIDWVTNKL	YWTDAGTDRI	EVANTDGSMR	TVLIWENLDR	PRDIVVEPMG	GYMYWTDWGA	SPKIERAGMD	ASGRQVIISS
901	911	921	931	941	951	961	971	981	991
NLTWPNGLAI	DYGSQRLYWA	DAGMKTIEFA	GLDGSKRKVL	IGSQLPHPFG	LTLYGERIYW	TDWQTKSIQS	ADRLTGLDRE	TLQENLENLM	DIHVFHRRRP
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
PVSTPCAMEN	GGCSHLCLRS	PNPSGFSCTC	PTGINLLSDG	KTCSPGMNSF	LIFARRIDIR	MVSLDIPYFA	DVVVPINITM	KNTIAIGVDP	QEGKVYWSDS
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
TLHRISRANL	DGSQHEDIIT	TGLQTTDGLA	VDAIGRKVYW	TDTGTNRIEV	GNLDGSMRKV	LVWQNLDSPR	AIVLYHEMGF	MYWTDWGENA	KLERSGMDGS
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
DRAVLINNNL	GWPNGLTVDK	ASSQLLWADA	HTERIEAADL	NGANRHTLVS	PVQHPYGLTL	LDSYIYWTDW	QTRSIHRADK	GTGSNVILVR	SNLPGLMDMQ
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
AVDRAQPLGF	NKCGSRNGGC	SHLCLPRPSG	FSCACPTGIQ	LKGDGKTCDP	SPETYLLFSS	RGSIRRISLD	TSDHTDVHVP	VPELNNVISL	DYDSVDGKVY
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
YTDVFLDVIR	RADLNGSNME	TVIGRGLKTT	DGLAVDWVAR	NLYWTDTGRN	TIEASRLDGS	CRKVLINNSL	DEPRAIAVFP	RKGYLFWTDW	GHIAKIERAN
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
LDGSERKVLI	NTDLGWPNGL	TLDYDTRRIY	WVDAHLDRIE	SADLNGKLRQ	VLVSHVSHPF	ALTQQDRWIY	WTDWQTKSIQ	RVDKYSGRNK	ETVLANVEGL
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
MDIIVVSPQR	QTGTNACGVN	NGGCTHLCFA	RASDFVCACP	DEPDSRPCSL	VPGLVPPAPR	ATGMSEKSPV	LPNTPPTTLY	SSTTRTRTSL	EEVEGRCSER
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
DARLGLCARS	NDAVPAAPGE	GLHISYAIGG	LLSILLILVV	IAALMLYRHK	KSKFTDPGMG	NLTYSNPSYR	TSTQEVKIEA	IPKPAMYNQL	CYKKEGGPDH
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
NYTKEKIKIV	EGICLLSGDD	AEWDDLKQLR	SSRGGLLRDH	VCMKTDTVSI	QASSGSLDDT	ETEQLLQEEQ	SECSSVHTAA	TPERRGSLPD	TGWKHERKLS
1901
SESQV

Reference

ID	Publication
12	Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
13	Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
15	Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203.
16	Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.