Detail


Protein	Low-density lipoprotein receptor-related protein 6
Gene	LRP6
Status	Reviewed
Source	Liver; OVCAR-3 cell line (Ovarian cancer); Prostate tumor
Years	2007-2015

Site	Identified Peptides	Year(Publication ID)
81	TEFnKTESVQNVVVSGLLSPDGLACDWLGEK	2015(1);
486	VVLVnTSLGWPNGLALDYDEGK	2014(33); 2015(1);
926	SLNADnRTCSAPTTF	2014(33);
1039	LnVTR	2014(33); 2007(unpublished);
1039	ATNVInVTR	2014(33);

Sequence

1	11	21	31	41	51	61	71	81	91
MGAVLRSLLA	CSFCVLLRAA	PLLLYANRRD	LRLVDATNGK	ENATIVVGGL	EDAAAVDFVF	SHGLIYWSDV	SEEAIKRTEF	NKTESVQNVV	VSGLLSPDGL
101	111	121	131	141	151	161	171	181	191
ACDWLGEKLY	WTDSETNRIE	VSNLDGSLRK	VLFWQELDQP	RAIALDPSSG	FMYWTDWGEV	PKIERAGMDG	SSRFIIINSE	IYWPNGLTLD	YEEQKLYWAD
201	211	221	231	241	251	261	271	281	291
AKLNFIHKSN	LDGTNRQAVV	KGSLPHPFAL	TLFEDILYWT	DWSTHSILAC	NKYTGEGLRE	IHSDIFSPMD	IHAFSQQRQP	NATNPCGIDN	GGCSHLCLMS
301	311	321	331	341	351	361	371	381	391
PVKPFYQCAC	PTGVKLLENG	KTCKDGATEL	LLLARRTDLR	RISLDTPDFT	DIVLQLEDIR	HAIAIDYDPV	EGYIYWTDDE	VRAIRRSFID	GSGSQFVVTA
401	411	421	431	441	451	461	471	481	491
QIAHPDGIAV	DWVARNLYWT	DTGTDRIEVT	RLNGTMRKIL	ISEDLEEPRA	IVLDPMVGYM	YWTDWGEIPK	IERAALDGSD	RVVLVNTSLG	WPNGLALDYD
501	511	521	531	541	551	561	571	581	591
EGKIYWGDAK	TDKIEVMNTD	GTGRRVLVED	KIPHIFGFTL	LGDYVYWTDW	QRRSIERVHK	RSAEREVIID	QLPDLMGLKA	TNVHRVIGSN	PCAEENGGCS
601	611	621	631	641	651	661	671	681	691
HLCLYRPQGL	RCACPIGFEL	ISDMKTCIVP	EAFLLFSRRA	DIRRISLETN	NNNVAIPLTG	VKEASALDFD	VTDNRIYWTD	ISLKTISRAF	MNGSALEHVV
701	711	721	731	741	751	761	771	781	791
EFGLDYPEGM	AVDWLGKNLY	WADTGTNRIE	VSKLDGQHRQ	VLVWKDLDSP	RALALDPAEG	FMYWTEWGGK	PKIDRAAMDG	SERTTLVPNV	GRANGLTIDY
801	811	821	831	841	851	861	871	881	891
AKRRLYWTDL	DTNLIESSNM	LGLNREVIAD	DLPHPFGLTQ	YQDYIYWTDW	SRRSIERANK	TSGQNRTIIQ	GHLDYVMDIL	VFHSSRQSGW	NECASSNGHC
901	911	921	931	941	951	961	971	981	991
SHLCLAVPVG	GFVCGCPAHY	SLNADNRTCS	APTTFLLFSQ	KSAINRMVID	EQQSPDIILP	IHSLRNVRAI	DYDPLDKQLY	WIDSRQNMIR	KAQEDGSQGF
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
TVVVSSVPSQ	NLEIQPYDLS	IDIYSRYIYW	TCEATNVINV	TRLDGRSVGV	VLKGEQDRPR	AVVVNPEKGY	MYFTNLQERS	PKIERAALDG	TEREVLFFSG
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
LSKPIALALD	SRLGKLFWAD	SDLRRIESSD	LSGANRIVLE	DSNILQPVGL	TVFENWLYWI	DKQQQMIEKI	DMTGREGRTK	VQARIAQLSD	IHAVKELNLQ
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
EYRQHPCAQD	NGGCSHICLV	KGDGTTRCSC	PMHLVLLQDE	LSCGEPPTCS	PQQFTCFTGE	IDCIPVAWRC	DGFTECEDHS	DELNCPVCSE	SQFQCASGQC
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
IDGALRCNGD	ANCQDKSDEK	NCEVLCLIDQ	FRCANGQCIG	KHKKCDHNVD	CSDKSDELDC	YPTEEPAPQA	TNTVGSVIGV	IVTIFVSGTV	YFICQRMLCP
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
RMKGDGETMT	NDYVVHGPAS	VPLGYVPHPS	SLSGSLPGMS	RGKSMISSLS	IMGGSSGPPY	DRAHVTGASS	SSSSSTKGTY	FPAILNPPPS	PATERSHYTM
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
EFGYSSNSPS	THRSYSYRPY	SYRHFAPPTT	PCSTDVCDSD	YAPSRRMTSV	ATAKGYTSDL	NYDSEPVPPP	PTPRSQYLSA	EENYESCPPS	PYTERSYSHH
1601	1611
LYPPPPSPCT	DSS

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.

UniProtKB-O75581

Glycosites

Sequence

Reference