Detail

UniProtKB-O94911


Protein	ATP-binding cassette sub-family A member 8
Gene	ABCA8
Status	Reviewed
Source	Colorectal tumor; Liver; Liver tumor (HCC); Ovarian tumor; Prostate; Prostate tumor; ovarian tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
71	VDTFnESR	2014(14); 2014(22); 2014(32); 2014(32); 2014(33); 2015(unpublished);2015(unpublished);
71	DLGRVDTFnESRF	2014(33);
71	TMDLGRVDTFnESRF	2014(33);
71	TMDLGRVDTFnESRFSVVY	2014(33);
84	TPVTnTTQQIM	2014(33);
84	TPVTnTTQQIMNK	2014(33);
84	FSVVYTPVTnTTQQIMNK	2009(64); 2011(54); 2014(22); 2014(33); 2007(unpublished);2007(unpublished);
84	TPVTnTTQQIMNKVASTPF	2014(33);
194	ITTnHSVMEE	2014(33);
194	EGFVALQAAINAAIIEITTnHSVMEELMSVTGK	2014(33);
879	FLAPGQQPHDPLTQLLIInK	2014(33);
879	LSPHLYFLAPGQQPHDPLTQLLIInK	2014(33);
908	FGTRnGTDDPSYNGA	2009(64);
927	nYSFSLACNAK	2014(14); 2014(22); 2014(33);
927	KnYSFSLACNAK	2014(33);
1268	nVSFCVR	2014(14);
1333	nITVR	2014(33);
1333	nLTVR	2014(33);

Sequence

1	11	21	31	41	51	61	71	81	91
MRKRKISVCQ	QTWALLCKNF	LKKWRMKRES	LMEWLNSLLL	LLCLYIYPHS	HQVNDFSSLL	TMDLGRVDTF	NESRFSVVYT	PVTNTTQQIM	NKVASTPFLA
101	111	121	131	141	151	161	171	181	191
GKEVLGLPDE	ESIKEFTANY	PEEIVRVTFT	NTYSYHLKFL	LGHGMPAKKE	HKDHTAHCYE	TNEDVYCEVS	VFWKEGFVAL	QAAINAAIIE	ITTNHSVMEE
201	211	221	231	241	251	261	271	281	291
LMSVTGKNMK	MHSFIGQSGV	ITDLYLFSCI	ISFSSFIYYA	SVNVTRERKR	MKALMTMMGL	RDSAFWLSWG	LLYAGFIFIM	ALFLALVIRS	TQFIILSGFM
301	311	321	331	341	351	361	371	381	391
VVFSLFLLYG	LSLVALAFLM	SILVKKSFLT	GLVVFLLTVF	WGCLGFTSLY	RHLPASLEWI	LSLLSPFAFM	LGMAQLLHLD	YDLNSNAFPH	PSDGSNLIVA
401	411	421	431	441	451	461	471	481	491
TNFMLAFDTC	LYLALAIYFE	KILPNEYGHR	RPPLFFLKSS	FWSQTQKTDH	VALEDEMDAD	PSFHDSFEQA	PPEFQGKEAI	RIRNVTKEYK	GKPDKIEALK
501	511	521	531	541	551	561	571	581	591
DLVFDIYEGQ	ITAILGHSGA	GKSTLLNILS	GLSVPTKGSV	TIYNNKLSEM	ADLENLSKLT	GVCPQSNVQF	DFLTVRENLR	LFAKIKGILP	QEVDKEIFLL
601	611	621	631	641	651	661	671	681	691
DEPTAGLDPF	SRHQVWNLLK	ERKTDRVILF	STQFMDEADI	LADRKVFLSQ	GKLKCAGSSL	FLKKKWGIGY	HLSLQLNEIC	VEENITSLVK	QHIPDAKLSA
701	711	721	731	741	751	761	771	781	791
KSEGKLIYTL	PLERTNKFPE	LYKDLDSYPD	LGIENYGVSM	TTLNEVFLKL	EGKSTINESD	IAILGEVQAE	KADDTERLVE	MEQVLSSLNK	MRKTIGGVAL
801	811	821	831	841	851	861	871	881	891
WRQQICAIAR	VRLLKLKHER	KALLALLLIL	MAGFCPLLVE	YTMVKIYQNS	YTWELSPHLY	FLAPGQQPHD	PLTQLLIINK	TGASIDDFIQ	SVEHQNIALE
901	911	921	931	941	951	961	971	981	991
VDAFGTRNGT	DDPSYNGAIT	VCCNEKNYSF	SLACNAKRLN	CFPVLMDIVS	NGLLGMVKPS	VHIRTERSTF	LENGQDNPIG	FLAYIMFWLV	LTSSCPPYIA
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
MSSIDDYKNR	ARSQLRISGL	SPSAYWFGQA	LVDVSLYFLV	FVFIYLMSYI	SNFEDMLLTI	IHIIQIPCAV	GYSFSLIFMT	YVISFIFRKG	RKNSGIWSFC
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
FYVVTVFSVA	GFAFSIFESD	IPFIFTFLIP	PATMIGCLFL	SSHLLFSSLF	SEERMDVQPF	LVFLIPFLHF	IIFLFTLRCL	EWKFGKKSMR	KDPFFRISPR
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
SSDVCQNPEE	PEGEDEDVQM	ERVRTANALN	STNFDEKPVI	IASCLRKEYA	GKRKGCFSKR	KNKIATRNVS	FCVRKGEVLG	LLGHNGAGKS	TSIKVITGDT
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
KPTAGQVLLK	GSGGGDALEF	LGYCPQENAL	WPNLTVRQHL	EVYAAVKGLR	KGDAEVAITR	LVDALKLQDQ	LKSPVKTLSE	GIKRKLCFVL	SILGNPSVVL
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
LDEPSTGMDP	EGQQQMWQAI	RATFRNTERG	ALLTTHYMAE	AEAVCDRVAI	MVSGRLRCIG	SIQHLKSKFG	KDYLLEMKVK	NLAQVEPLHA	EILRLFPQAA
1501	1511	1521	1531	1541	1551	1561	1571	1581
RQERYSSLMV	YKLPVEDVQP	LAQAFFKLEK	VKQSFDLEEY	SLSQSTLEQV	FLELSKEQEL	GDFEEDFDPS	VKWKLLPQEE	P

Reference

ID	Publication
14	Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32	Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
54	Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
64	Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.