Contains      

UniProtKB-O95479

Protein GDH/6PGL endoplasmic bifunctional protein
Gene H6PD
Status Reviewed
Source Breast Cancer cell lines; Colorectal cancer cell line, HCT-116 (colorectal cancer)Jurkat T cell line; DLBCL cell lines (Diffuse large B-cell lymphoma); Jurkat T cell line; LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Platelet; Prostate tumor; Serum
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
157 NInSSCR 2014(32); 2014(33);
157 InSSCRPGPG 2009(64);
157 InSSCRPGPGAW 2014(33);
157 DIARNInSSCRPG 2013(37);
157 NInSSCRPGPGAW 2014(33);
157 nSSCRPGPGAWLR 2014(33);
157 InSSCRPGPGAWLR 2014(33);
157 NInSSCRPGPGAWL 2014(33);
157 NInSSCRPGPGAWIR 2014(16);
157 NInSSCRPGPGAWLR 2014(13); 2014(33); 2015(1);
157 DIARNInSSCRPGPGAW 2009(64);
157 EDIARNInSSCRPGPGAW 2014(33);
157 FSVPPFAYEDIARNInSS 2014(33);
157 EDIARNInSSCRPGPGAWL 2014(33);
157 AYEDIARNInSSCRPGPGAW 2014(33);
157 AYEDIARNInSSCRPGPGAWL 2014(33);
282 LPHnVSSAE 2014(33);
282 ELPHnVSSAE 2014(33);
282 nVSSAEAVLR 2015(1);
282 MELPHnVSSAE 2009(64);
282 ELPHnVSSAEAVL 2014(33);
282 LPHnVSSAEAVLR 2014(33);
282 VAMELPHnVSSAE 2014(33);
282 ELPHnVSSAEAVLR 2014(33); 2015(unpublished);
282 MELPHnVSSAEAVLR 2014(33);
282 TLVAMELPHnVSSAE 2014(33);
282 VAMELPHnVSSAEAVL 2014(33);
282 VAMELPHnVSSAEAVLR 2014(33);
282 VLTLVAMELPHnVSSAE 2014(33);
282 TLVAMELPHnVSSAEAVL 2014(33);
282 TLVAMELPHnVSSAEAVLR 2014(33);
282 VLTLVAMELPHnVSSAEAVLR 2014(33);
282 DVIQNHITEVITIVAMEIPHnVSSAEAVIR 2014(16);
282 DVLQNHLTEVLTLVAMELPHnVSSAEAVLR 2009(64); 2011(58); 2014(13); 2014(33); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2007;2007;
282 YGVIRDVLQNHLTEVLTLVAMELPHnVSSAEAVLR 2014(33);
282 TSFYEEYGVIRDVLQNHLTEVLTLVAMELPHnVSSAEAVLR 2015(2);
683 ISALVAnSSFD 2014(33);
683 EISALVAnSSFD 2014(33);
683 AREISALVAnSSF 2014(33);
683 VAnSSFDLVLLGMGADGHTA 2014(33);

Sequence

1112131415161718191
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKD
101111121131141151161171181191
QFLQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMY
201211221231241251261271281291
RVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
301311321331341351361371381391
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVF
401411421431441451461471481491
HIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRL
501511521531541551561571581591
YPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
601611621631641651661671681691
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTA
701711721731741751761771781791
SLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.