Detail


Protein	E3 ubiquitin-protein ligase HERC2
Gene	HERC2
Status	Reviewed
Source	Breast tumor; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Serum
Years	2007-2015

Site	Identified Peptides	Year(Publication ID)
2488	SLTGASGnASSLPGVEALVGWLLD	2014(27);
2790	SLnVSSSVNQASR	2007(unpublished);2007(unpublished);2007(unpublished);
3291	nGTTTVNR	2015(1);
3746	LNLASnR	2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MPSESFCLAA	QARLDSKWLK	TDIQLAFTRD	GLCGLWNEMV	KDGEIVYTGT	ESTQNGELPP	RKDDSVEPSG	TKKEDLNDKE	KKDEEETPAP	IYRAKSILDS
101	111	121	131	141	151	161	171	181	191
WVWGKQPDVN	ELKECLSVLV	KEQQALAVQS	ATTTLSALRL	KQRLVILERY	FIALNRTVFQ	ENVKVKWKSS	GISLPPVDKK	SSRPAGKGVE	GLARVGSRAA
201	211	221	231	241	251	261	271	281	291
LSFAFAFLRR	AWRSGEDADL	CSELLQESLD	ALRALPEASL	FDESTVSSVW	LEVVERATRF	LRSVVTGDVH	GTPATKGPGS	IPLQDQHLAL	AILLELAVQR
301	311	321	331	341	351	361	371	381	391
GTLSQMLSAI	LLLLQLWDSG	AQETDNERSA	QGTSAPLLPL	LQRFQSIICR	KDAPHSEGDM	HLLSGPLSPN	ESFLRYLTLP	QDNELAIDLR	QTAVVVMAHL
401	411	421	431	441	451	461	471	481	491
DRLATPCMPP	LCSSPTSHKG	SLQEVIGWGL	IGWKYYANVI	GPIQCEGLAN	LGVTQIACAE	KRFLILSRNG	RVYTQAYNSD	TLAPQLVQGL	ASRNIVKIAA
501	511	521	531	541	551	561	571	581	591
HSDGHHYLAL	AATGEVYSWG	CGDGGRLGHG	DTVPLEEPKV	ISAFSGKQAG	KHVVHIACGS	TYSAAITAEG	ELYTWGRGNY	GRLGHGSSED	EAIPMLVAGL
601	611	621	631	641	651	661	671	681	691
KGLKVIDVAC	GSGDAQTLAV	TENGQVWSWG	DGDYGKLGRG	GSDGCKTPKL	IEKLQDLDVV	KVRCGSQFSI	ALTKDGQVYS	WGKGDNQRLG	HGTEEHVRYP
701	711	721	731	741	751	761	771	781	791
KLLEGLQGKK	VIDVAAGSTH	CLALTEDSEV	HSWGSNDQCQ	HFDTLRVTKP	EPAALPGLDT	KHIVGIACGP	AQSFAWSSCS	EWSIGLRVPF	VVDICSMTFE
801	811	821	831	841	851	861	871	881	891
QLDLLLRQVS	EGMDGSADWP	PPQEKECVAV	ATLNLLRLQL	HAAISHQVDP	EFLGLGLGSI	LLNSLKQTVV	TLASSAGVLS	TVQSAAQAVL	QSGWSVLLPT
901	911	921	931	941	951	961	971	981	991
AEERARALSA	LLPCAVSGNE	VNISPGRRFM	IDLLVGSLMA	DGGLESALHA	AITAEIQDIE	AKKEAQKEKE	IDEQEANAST	FHRSRTPLDK	DLINTGICES
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
SGKQCLPLVQ	LIQQLLRNIA	SQTVARLKDV	ARRISSCLDF	EQHSRERSAS	LDLLLRFQRL	LISKLYPGES	IGQTSDISSP	ELMGVGSLLK	KYTALLCTHI
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
GDILPVAASI	ASTSWRHFAE	VAYIVEGDFT	GVLLPELVVS	IVLLLSKNAG	LMQEAGAVPL	LGGLLEHLDR	FNHLAPGKER	DDHEELAWPG	IMESFFTGQN
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
CRNNEEVTLI	RKADLENHNK	DGGFWTVIDG	KVYDIKDFQT	QSLTGNSILA	QFAGEDPVVA	LEAALQFEDT	RESMHAFCVG	QYLEPDQEIV	TIPDLGSLSS
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
PLIDTERNLG	LLLGLHASYL	AMSTPLSPVE	IECAKWLQSS	IFSGGLQTSQ	IHYSYNEEKD	EDHCSSPGGT	PASKSRLCSH	RRALGDHSQA	FLQAIADNNI
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
QDHNVKDFLC	QIERYCRQCH	LTTPIMFPPE	HPVEEVGRLL	LCCLLKHEDL	GHVALSLVHA	GALGIEQVKH	RTLPKSVVDV	CRVVYQAKCS	LIKTHQEQGR
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
SYKEVCAPVI	ERLRFLFNEL	RPAVCNDLSI	MSKFKLLSSL	PRWRRIAQKI	IRERRKKRVP	KKPESTDDEE	KIGNEESDLE	EACILPHSPI	NVDKRPIAIK
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
SPKDKWQPLL	STVTGVHKYK	WLKQNVQGLY	PQSPLLSTIA	EFALKEEPVD	VEKMRKCLLK	QLERAEVRLE	GIDTILKLAS	KNFLLPSVQY	AMFCGWQRLI
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
PEGIDIGEPL	TDCLKDVDLI	PPFNRMLLEV	TFGKLYAWAV	QNIRNVLMDA	SAKFKELGIQ	PVPLQTITNE	NPSGPSLGTI	PQARFLLVML	SMLTLQHGAN
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
NLDLLLNSGM	LALTQTALRL	IGPSCDNVEE	DMNASAQGAS	ATVLEETRKE	TAPVQLPVSG	PELAAMMKIG	TRVMRGVDWK	WGDQDGPPPG	LGRVIGELGE
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
DGWIRVQWDT	GSTNSYRMGK	EGKYDLKLAE	LPAAAQPSAE	DSDTEDDSEA	EQTERNIHPT	AMMFTSTINL	LQTLCLSAGV	HAEIMQSEAT	KTLCGLLRML
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
VESGTTDKTS	SPNRLVYREQ	HRSWCTLGFV	RSIALTPQVC	GALSSPQWIT	LLMKVVEGHA	PFTATSLQRQ	ILAVHLLQAV	LPSWDKTERA	RDMKCLVEKL
2101	2111	2121	2131	2141	2151	2161	2171	2181	2191
FDFLGSLLTT	CSSDVPLLRE	STLRRRRVRP	QASLTATHSS	TLAEEVVALL	RTLHSLTQWN	GLINKYINSQ	LRSITHSFVG	RPSEGAQLED	YFPDSENPEV
2201	2211	2221	2231	2241	2251	2261	2271	2281	2291
GGLMAVLAVI	GGIDGRLRLG	GQVMHDEFGE	GTVTRITPKG	KITVQFSDMR	TCRVCPLNQL	KPLPAVAFNV	NNLPFTEPML	SVWAQLVNLA	GSKLEKHKIK
2301	2311	2321	2331	2341	2351	2361	2371	2381	2391
KSTKQAFAGQ	VDLDLLRCQQ	LKLYILKAGR	ALLSHQDKLR	QILSQPAVQE	TGTVHTDDGA	VVSPDLGDMS	PEGPQPPMIL	LQQLLASATQ	PSPVKAIFDK
2401	2411	2421	2431	2441	2451	2461	2471	2481	2491
QELEAAALAV	CQCLAVESTH	PSSPGFEDCS	SSEATTPVAV	QHIRPARVKR	RKQSPVPALP	IVVQLMEMGF	SRRNIEFALK	SLTGASGNAS	SLPGVEALVG
2501	2511	2521	2531	2541	2551	2561	2571	2581	2591
WLLDHSDIQV	TELSDADTVS	DEYSDEEVVE	DVDDAAYSMS	TGAVVTESQT	YKKRADFLSN	DDYAVYVREN	IQVGMMVRCC	RAYEEVCEGD	VGKVIKLDRD
2601	2611	2621	2631	2641	2651	2661	2671	2681	2691
GLHDLNVQCD	WQQKGGTYWV	RYIHVELIGY	PPPSSSSHIK	IGDKVRVKAS	VTTPKYKWGS	VTHQSVGVVK	AFSANGKDII	VDFPQQSHWT	GLLSEMELVP
2701	2711	2721	2731	2741	2751	2761	2771	2781	2791
SIHPGVTCDG	CQMFPINGSR	FKCRNCDDFD	FCETCFKTKK	HNTRHTFGRI	NEPGQSAVFC	GRSGKQLKRC	HSSQPGMLLD	SWSRMVKSLN	VSSSVNQASR
2801	2811	2821	2831	2841	2851	2861	2871	2881	2891
LIDGSEPCWQ	SSGSQGKHWI	RLEIFPDVLV	HRLKMIVDPA	DSSYMPSLVV	VSGGNSLNNL	IELKTININP	SDTTVPLLND	CTEYHRYIEI	AIKQCRSSGI
2901	2911	2921	2931	2941	2951	2961	2971	2981	2991
DCKIHGLILL	GRIRAEEEDL	AAVPFLASDN	EEEEDEKGNS	GSLIRKKAAG	LESAATIRTK	VFVWGLNDKD	QLGGLKGSKI	KVPSFSETLS	ALNVVQVAGG
3001	3011	3021	3031	3041	3051	3061	3071	3081	3091
SKSLFAVTVE	GKVYACGEAT	NGRLGLGISS	GTVPIPRQIT	ALSSYVVKKV	AVHSGGRHAT	ALTVDGKVFS	WGEGDDGKLG	HFSRMNCDKP	RLIEALKTKR
3101	3111	3121	3131	3141	3151	3161	3171	3181	3191
IRDIACGSSH	SAALTSSGEL	YTWGLGEYGR	LGHGDNTTQL	KPKMVKVLLG	HRVIQVACGS	RDAQTLALTD	EGLVFSWGDG	DFGKLGRGGS	EGCNIPQNIE
3201	3211	3221	3231	3241	3251	3261	3271	3281	3291
RLNGQGVCQI	ECGAQFSLAL	TKSGVVWTWG	KGDYFRLGHG	SDVHVRKPQV	VEGLRGKKIV	HVAVGALHCL	AVTDSGQVYA	WGDNDHGQQG	NGTTTVNRKP
3301	3311	3321	3331	3341	3351	3361	3371	3381	3391
TLVQGLEGQK	ITRVACGSSH	SVAWTTVDVA	TPSVHEPVLF	QTARDPLGAS	YLGVPSDADS	SAASNKISGA	SNSKPNRPSL	AKILLSLDGN	LAKQQALSHI
3401	3411	3421	3431	3441	3451	3461	3471	3481	3491
LTALQIMYAR	DAVVGALMPA	AMIAPVECPS	FSSAAPSDAS	AMASPMNGEE	CMLAVDIEDR	LSPNPWQEKR	EIVSSEDAVT	PSAVTPSAPS	ASARPFIPVT
3501	3511	3521	3531	3541	3551	3561	3571	3581	3591
DDLGAASIIA	ETMTKTKEDV	ESQNKAAGPE	PQALDEFTSL	LIADDTRVVV	DLLKLSVCSR	AGDRGRDVLS	AVLSGMGTAY	PQVADMLLEL	CVTELEDVAT
3601	3611	3621	3631	3641	3651	3661	3671	3681	3691
DSQSGRLSSQ	PVVVESSHPY	TDDTSTSGTV	KIPGAEGLRV	EFDRQCSTER	RHDPLTVMDG	VNRIVSVRSG	REWSDWSSEL	RIPGDELKWK	FISDGSVNGW
3701	3711	3721	3731	3741	3751	3761	3771	3781	3791
GWRFTVYPIM	PAAGPKELLS	DRCVLSCPSM	DLVTCLLDFR	LNLASNRSIV	PRLAASLAAC	AQLSALAASH	RMWALQRLRK	LLTTEFGQSI	NINRLLGEND
3801	3811	3821	3831	3841	3851	3861	3871	3881	3891
GETRALSFTG	SALAALVKGL	PEALQRQFEY	EDPIVRGGKQ	LLHSPFFKVL	VALACDLELD	TLPCCAETHK	WAWFRRYCMA	SRVAVALDKR	TPLPRLFLDE
3901	3911	3921	3931	3941	3951	3961	3971	3981	3991
VAKKIRELMA	DSENMDVLHE	SHDIFKREQD	EQLVQWMNRR	PDDWTLSAGG	SGTIYGWGHN	HRGQLGGIEG	AKVKVPTPCE	ALATLRPVQL	IGGEQTLFAV
4001	4011	4021	4031	4041	4051	4061	4071	4081	4091
TADGKLYATG	YGAGGRLGIG	GTESVSTPTL	LESIQHVFIK	KVAVNSGGKH	CLALSSEGEV	YSWGEAEDGK	LGHGNRSPCD	RPRVIESLRG	IEVVDVAAGG
4101	4111	4121	4131	4141	4151	4161	4171	4181	4191
AHSACVTAAG	DLYTWGKGRY	GRLGHSDSED	QLKPKLVEAL	QGHRVVDIAC	GSGDAQTLCL	TDDDTVWSWG	DGDYGKLGRG	GSDGCKVPMK	IDSLTGLGVV
4201	4211	4221	4231	4241	4251	4261	4271	4281	4291
KVECGSQFSV	ALTKSGAVYT	WGKGDYHRLG	HGSDDHVRRP	RQVQGLQGKK	VIAIATGSLH	CVCCTEDGEV	YTWGDNDEGQ	LGDGTTNAIQ	RPRLVAALQG
4301	4311	4321	4331	4341	4351	4361	4371	4381	4391
KKVNRVACGS	AHTLAWSTSK	PASAGKLPAQ	VPMEYNHLQE	IPIIALRNRL	LLLHHLSELF	CPCIPMFDLE	GSLDETGLGP	SVGFDTLRGI	LISQGKEAAF
4401	4411	4421	4431	4441	4451	4461	4471	4481	4491
RKVVQATMVR	DRQHGPVVEL	NRIQVKRSRS	KGGLAGPDGT	KSVFGQMCAK	MSSFGPDSLL	LPHRVWKVKF	VGESVDDCGG	GYSESIAEIC	EELQNGLTPL
4501	4511	4521	4531	4541	4551	4561	4571	4581	4591
LIVTPNGRDE	SGANRDCYLL	SPAARAPVHS	SMFRFLGVLL	GIAIRTGSPL	SLNLAEPVWK	QLAGMSLTIA	DLSEVDKDFI	PGLMYIRDNE	ATSEEFEAMS
4601	4611	4621	4631	4641	4651	4661	4671	4681	4691
LPFTVPSASG	QDIQLSSKHT	HITLDNRAEY	VRLAINYRLH	EFDEQVAAVR	EGMARVVPVP	LLSLFTGYEL	ETMVCGSPDI	PLHLLKSVAT	YKGIEPSASL
4701	4711	4721	4731	4741	4751	4761	4771	4781	4791
IQWFWEVMES	FSNTERSLFL	RFVWGRTRLP	RTIADFRGRD	FVIQVLDKYN	PPDHFLPESY	TCFFLLKLPR	YSCKQVLEEK	LKYAIHFCKS	IDTDDYARIA
4801	4811	4821	4831
LTGEPAADDS	SDDSDNEDVD	SFASDSTQDY	LTGH

UniProtKB-O95714

Glycosites

Sequence

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
27	Wang J, Zhou C, Zhang W, Yao J, Lu HJ, Dong QZ, Zhou HJ, Qin LX: An integrative strategy for quantitative analysis of the N-glycoproteome in complex biological samples. Proteome Science 2014, 12.