Contains      

UniProtKB-P01903

Protein HLA class II histocompatibility antigen, DR alpha chain
Gene HLA-DRA
Status Reviewed
Source Breast cancer xenografts; Breast cancer xenograftsPBMC Macrophage cells; Breast cell lines; Breast tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); Liver; Lymphocytes; Ovarian tumor; Prostate; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
103 RSnYTPITNVPPE 2014(33);
103 SnYTPITNVPPEVTVL 2014(33);
103 RSnYTPITNVPPEVTVL 2014(33);
103 SnYTPITNVPPEVTVITNSPVEIR 2014(16);
103 SnYTPITNVPPEVTVLTNSPVELR 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;2007;
103 RSnYTPITNVPPEVTVITNSPVEIR 2014(16); 2014(32);
103 RSnYTPITNVPPEVTVLTNSPVELR 2009(64); 2012(52); 2013(34); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);
143 TPPVVnVTW 2014(33);
143 FTPPVVnVTW 2014(33);
143 PPVVnVTWLR 2014(33);
143 TPPVVnVTWL 2014(33);
143 TPPVVnVTWLR 2014(33);
143 FTPPVVnVTWIR 2014(16); 2014(32);
143 FTPPVVnVTWLR 2007(64); 2009(52); 2012(34); 2013(33); 2014(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;2007;
143 FTPPVVnVTWLRN 2015(unpublished);
143 IDKFTPPVVnVTW 2009(64); 2014(33);
143 IDKFTPPVVnVTWL 2009(64); 2014(33);
143 ICFIDKFTPPVVnVT 2014(33);
143 IDKFTPPVVnVTWLR 2014(33);
143 ICFIDKFTPPVVnVTW 2014(33);
143 ICFIDKFTPPVVnVTWL 2014(33);
143 EPNVLICFIDKFTPPVVnVTWLR 2009(64); 2014(33);

Sequence

1112131415161718191
MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTK
101111121131141151161171181191
RSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLL
201211221231241251
KHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGVRKSNAAERRGPL

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.