Contains      

UniProtKB-P02788

Protein Lactotransferrin
Gene LTF
Status Reviewed
Source Bladder tumor; Breast cancer xenografts; Breast tumor; Colorectal tumor; Colorectal tumors; Liver; Ovarian tumor; Plasma; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Saliva; Serum; Spermatozoa; Urine; milk
Years 2007-20072007

Glycosites

Site Identified Peptides Year(Publication ID)
156 LnWTGPPEPIEAAVAR 2007(unpublished);
156 PFLnWTGPPEPIEAAVAR 2014(33); 2015(unpublished);
156 LRPFLnWTGPPEPIEAAVAR 2015(unpublished);
156 NVPIGTLRPFLnWTGPPEPIEAAVAR 2015(unpublished);
156 NVPIGTLRPFLnWTGPPEPIEAAVARF 2014(33);
156 TAGWNVPIGTIRPFInWTGPPEPIEAAVAR 2013(43);
156 TAGWNVPIGTLRPFLnWTGPPEPIEAAVAR 2008(70); 2009(68); 2012(53); 2013(45); 2014(30); 2014(33); 2015(unpublished);2015(unpublished);2007(unpublished);2007(UnpublishedUnpublished ); 2007;20072007 ;
156 RTAGWNVPIGTLRPFLnWTGPPEPIEAAVAR 2008(70);
497 LFnQTGSCK 2012(3); 2015(unpublished);
497 LFnQTGSCKF 2014(33);
497 LLFnQTGSCK 2009(64);
497 GLLFnQTGSCK 2014(14);
497 LFnQTGSCKFDEY 2014(33);
497 LFnQTGSCKFDEYF 2014(33);
497 GLLFnQTGSCKFDEY 2014(33);
497 NIPMGLLFnQTGSCKFDEY 2014(33);
497 TAGWNIPMGIIFnQTGSCK 2013(43);
497 TAGWNIPMGLLFnQTGSCK 2007(70); 2008(51); 2012(45); 2013(13); 2014(22); 2014(30); 2014(33); 2014(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2015;2015;2007;2007;2007;2007;20072007 ;
497 TAGWNIPMGLLFnQTGSCKFDE 2014(33);
642 GRnGSDCPDKF 2014(33);
642 nGSDCPDKFCLFQSETK 2008(70); 2013(45); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);
642 FGRnGSDCPDKFCLFQSETK 2007(unpublished);

Sequence

1112131415161718191
MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEV
101111121131141151161171181191
YGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKC
201211221231241251261271281291
AFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKD
301311321331341351361371381391
KSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCI
401411421431441451461471481491
ALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTG
501511521531541551561571581591
SCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRK
601611621631641651661671681691
PVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSP
701
LLEACEFLRK

Reference

ID Publication
3Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
30Xu Y, Bailey U-M, Punyadeera C, Schulz BL: Identification of salivary N-glycoproteins and measurement of glycosylation site occupancy by boronate glycoprotein enrichment and liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2014, 28:471-482.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
43Wang GG, Wu YB, Zhou T, Guo YS, Zheng B, Wang J, Bi Y, Liu FJ, Zhou ZM, Guo XJ, Sha JH: Mapping of the N-Linked Glycoproteome of Human Spermatozoa. Journal of Proteome Research 2013, 12:5750-5759.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
51Yeh C-H, Chen S-H, Li D-T, Lin H-P, Huang H-J, Chang C-I, Shih W-L, Chern C-L, Shi F-K, Hsu J-L: Magnetic bead-based hydrophilic interaction liquid chromatography for glycopeptide enrichments. Journal of Chromatography A 2012, 1224:70-78.
53Zhu J, Wang F, Chen R, Cheng K, Xu B, Guo Z, Liang X, Ye M, Zou H: Centrifugation Assisted Microreactor Enables Facile Integration of Trypsin Digestion, Hydrophilic Interaction Chromatography Enrichment, and On-Column Deglycosylation for Rapid and Sensitive N-Glycoproteome Analysis. Analytical Chemistry 2012, 84:5146-5153.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
68Zhang L, Xu Y, Yao H, Xie L, Yao J, Lu H, Yang P: Boronic Acid Functionalized Core-Satellite Composite Nanoparticles for Advanced Enrichment of Glycopeptides and Glycoproteins. Chemistry-a European Journal 2009, 15:10158-10166.
70Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics 2008, 8:3833-3847.