Contains      

UniProtKB-P04839

Protein Cytochrome b-245 heavy chain
Gene CYBB
Status Reviewed
Source Breast tumor; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); Liver; Liver tumor (HCC); Ovarian tumor; Ovarian tumorPBMC Macrophage cells; Prostate; Prostate tumor; Urine; ovarian tumor
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
132 RVnNSDPY 2014(33);
132 ARVnNSDPY 2014(33);
132 VnNSDPYSVAL 2014(33);
132 CVNARVnNSDPY 2014(33);
132 VNARVnNSDPYS 2009(64);
132 VnNSDPYSVALSE 2014(33);
132 VnNSDPYSVAISEIGDR 2014(16);
132 VnNSDPYSVALSELGDR 2011(54); 2014(14); 2014(22); 2014(33); 2015(unpublished);2007(unpublished);2007;
132 VnNSDPYSVAISEIGDRQNESYINFAR 2014(16);
132 VnNSDPYSVALSELGDRQNESYLNFAR 2013(34); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);
149 LGDRQnESY 2009(64);
149 LGDRQnESYL 2014(33);
149 QnESYINFAR 2014(16);
149 QnESYLNFAR 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2007;2007;
149 ELGDRQnESYL 2014(33);
149 SELGDRQnESY 2014(33);
149 SELGDRQnESYL 2014(33);
149 SELGDRQnESYLNF 2014(33);
149 SVALSELGDRQnESY 2014(33);
149 SVALSELGDRQnESYL 2014(33);
149 SVALSELGDRQnESYLNF 2014(33);
149 SVALSELGDRQnESYLNFAR 2014(33);
149 VNNSDPYSVAISEIGDRQnESYINFAR 2014(16);
149 VNNSDPYSVALSELGDRQnESYLNFAR 2013(34); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);
240 HnITVCEQK 2015(unpublished);
240 AVHnITVCEQ 2014(33);
240 VHnITVCEQK 2014(14); 2014(33);
240 AVHnITVCEQK 2014(33);
240 SLAVHnITVCE 2014(33);
240 nITVCEQKISEW 2014(33);
240 SLAVHnITVCEQK 2014(33);
240 AVHnITVCEQKISEW 2014(33);
240 GQTAESIAVHnITVCEQK 2014(16); 2014(32);
240 GQTAESLAVHnITVCEQK 2009(64); 2013(34); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;

Sequence

1112131415161718191
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTF
101111121131141151161171181191
HKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRS
201211221231241251261271281291
YFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
301311321331341351361371381391
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFS
401411421431441451461471481491
YEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKD
501511521531541551561
VITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.