| Protein | Insulin receptor |
| Gene | INSR |
| Status | Reviewed |
| Source | 22Rv1 cell line (prostate cancer); Breast Cancer cell lines; Breast cancer xenografts; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HEK293 cell line (embryonic kidney); HEK293T cell line (embryonic kidney), HEK293T cell line (embryonic kidney); Hela cell line (cervical cancer); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Lymphocytes; Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; Urine |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 43 | NnLTRL | 2014(33); |
| 52 | LHELEnCSVIE | 2014(33); |
| 105 | DLFPnLTVIR | 2014(33); |
| 138 | NLMnITR | 2014(33); |
| 138 | LGLYNLMnITR | 2014(33); |
| 138 | EIGIYNIMnITR | 2014(16); 2014(32); 2014(32); |
| 138 | ELGLYNLMnITR | 2007(48); 2012(40); 2013(14); 2014(33); 2014(1); 2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007; |
| 138 | FEMVHLKELGLYNLMnITR | 2012(48); |
| 242 | nCSQPDDPTK | 2015(1); |
| 242 | CLGnCSQPDDPTK | 2014(33); |
| 242 | LGnCSQPDDPTKC | 2009(64); |
| 242 | CCHSECLGnCSQPDDPTKCVACRNF | 2014(33); |
| 242 | CCHSECLGnCSQPDDPTKCVACRNFY | 2014(33); |
| 242 | SHGCTAEGICCHSECIGnCSQPDDPTK | 2014(16); |
| 242 | SHGCTAEGLCCHSECLGnCSQPDDPTK | 2014(18); 2014(33); |
| 242 | SHGCTAEGLCCHSECLGnCSQPDDPTKCVACR | 2014(18); |
| 282 | CVnFSFCQD | 2014(33); |
| 282 | CVnFSFCQDIHHK | 2014(16); |
| 282 | CVnFSFCQDLHHK | 2014(33); 2015(unpublished); |
| 322 | nSSNLLCTPCLGPCPK | 2015(1); |
| 424 | IRGETLEIGnY | 2014(33); |
| 424 | IGnYSFYALDNQNLR | 2014(33); |
| 424 | GETIEIGnYSFYAIDNQNIR | 2014(32); 2014(32); |
| 424 | GETLEIGnYSFYALDNQNLR | 2014(33); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);2007;2007; |
| 424 | IIRGETIEIGnYSFYAIDNQNIR | 2014(16); |
| 445 | nLTITQGK | 2015(1); |
| 445 | HnLTITQGK | 2012(48); 2012(50); 2013(34); 2014(22); 2014(33); 2015(unpublished);2015(2); 2015(unpublished);2015(unpublished);2015(9); |
| 445 | WDWSKHnITITQG | 2013(37); |
| 445 | DWSKHnLTITQGKL | 2014(33); |
| 445 | DWSKHnLTITQGKLF | 2014(33); |
| 445 | QIWDWSKHnITITQGK | 2014(16); |
| 541 | EAPYQnVTE | 2014(33); |
| 541 | KEAPYQnVTEF | 2014(33); |
| 541 | YKEAPYQnVTE | 2009(64); |
| 541 | YKEAPYQnVTEF | 2014(33); |
| 541 | FYKEAPYQnVTEF | 2009(64); |
| 541 | YKEAPYQnVTEFDGQDACGSNSW | 2014(33); |
| 541 | EAPYQnVTEFDGQDACGSNSWTVVDIDPPLR | 2014(33); |
| 633 | nSSSQIILK | 2015(1); |
| 633 | ATNPSVPLDPISVSnSSSQIILK | 2014(33); 2007(unpublished);2007(unpublished); |
| 633 | TDATNPSVPLDPISVSnSSSQIILK | 2014(33); |
| 633 | VQTDATNPSVPLDPISVSnSSSQIILK | 2014(33); |
| 633 | SDIIYVQTDATNPSVPLDPISVSnSSSQIILK | 2015(unpublished);2015(unpublished); |
| 651 | KPPSDPNGnITHY | 2014(33); |
| 651 | WKPPSDPNGnITHY | 2014(33); |
| 651 | KWKPPSDPNGnITHY | 2014(33); |
| 651 | WKPPSDPNGnITHYIVFWER | 2014(16); |
| 651 | WKPPSDPNGnITHYLVFWER | 2011(58); 2014(33); 2015(unpublished);2015(2); |
| 698 | HnQSEYEDSAGE | 2014(33); |
| 698 | nQSEYEDSAGECCSCPK | 2015(1); |
| 698 | HnQSEYEDSAGECCSCPK | 2013(38); 2014(22); 2014(33); |
| 698 | TWSPPFESEDSQKHnQSEYEDSAGECCSCPK | 2014(16); 2014(33); |
| 920 | RGLSPGnY | 2014(33); |
| 920 | LRGLSPGnY | 2014(33); |
| 920 | GISPGnYSVR | 2014(32); |
| 920 | GLSPGnYSVR | 2012(48); 2012(50); 2013(40); 2014(22); 2014(33); 2015(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007; |
| 920 | IRGISPGnYSVR | 2014(16); |
| 920 | LRGLSPGnYSVR | 2014(15); 2015(2); |
| 920 | RGISPGnYSVRIR | 2013(37); |
| 933 | AGnGSWTEPTYF | 2014(33); |
| 933 | SLAGnGSWTEPTYF | 2014(33); |
| 933 | ATSLAGnGSWTEPTYF | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MATGGRRGAA | AAPLLVAVAA | LLLGAAGHLY | PGEVCPGMDI | RNNLTRLHEL | ENCSVIEGHL | QILLMFKTRP | EDFRDLSFPK | LIMITDYLLL | FRVYGLESLK |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| DLFPNLTVIR | GSRLFFNYAL | VIFEMVHLKE | LGLYNLMNIT | RGSVRIEKNN | ELCYLATIDW | SRILDSVEDN | YIVLNKDDNE | ECGDICPGTA | KGKTNCPATV |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| INGQFVERCW | THSHCQKVCP | TICKSHGCTA | EGLCCHSECL | GNCSQPDDPT | KCVACRNFYL | DGRCVETCPP | PYYHFQDWRC | VNFSFCQDLH | HKCKNSRRQG |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| CHQYVIHNNK | CIPECPSGYT | MNSSNLLCTP | CLGPCPKVCH | LLEGEKTIDS | VTSAQELRGC | TVINGSLIIN | IRGGNNLAAE | LEANLGLIEE | ISGYLKIRRS |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| YALVSLSFFR | KLRLIRGETL | EIGNYSFYAL | DNQNLRQLWD | WSKHNLTITQ | GKLFFHYNPK | LCLSEIHKME | EVSGTKGRQE | RNDIALKTNG | DQASCENELL |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| KFSYIRTSFD | KILLRWEPYW | PPDFRDLLGF | MLFYKEAPYQ | NVTEFDGQDA | CGSNSWTVVD | IDPPLRSNDP | KSQNHPGWLM | RGLKPWTQYA | IFVKTLVTFS |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| DERRTYGAKS | DIIYVQTDAT | NPSVPLDPIS | VSNSSSQIIL | KWKPPSDPNG | NITHYLVFWE | RQAEDSELFE | LDYCLKGLKL | PSRTWSPPFE | SEDSQKHNQS |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| EYEDSAGECC | SCPKTDSQIL | KELEESSFRK | TFEDYLHNVV | FVPRKTSSGT | GAEDPRPSRK | RRSLGDVGNV | TVAVPTVAAF | PNTSSTSVPT | SPEEHRPFEK |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| VVNKESLVIS | GLRHFTGYRI | ELQACNQDTP | EERCSVAAYV | SARTMPEAKA | DDIVGPVTHE | IFENNVVHLM | WQEPKEPNGL | IVLYEVSYRR | YGDEELHLCV |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| SRKHFALERG | CRLRGLSPGN | YSVRIRATSL | AGNGSWTEPT | YFYVTDYLDV | PSNIAKIIIG | PLIFVFLFSV | VIGSIYLFLR | KRQPDGPLGP | LYASSNPEYL |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
| SASDVFPCSV | YVPDEWEVSR | EKITLLRELG | QGSFGMVYEG | NARDIIKGEA | ETRVAVKTVN | ESASLRERIE | FLNEASVMKG | FTCHHVVRLL | GVVSKGQPTL |
| 1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
| VVMELMAHGD | LKSYLRSLRP | EAENNPGRPP | PTLQEMIQMA | AEIADGMAYL | NAKKFVHRDL | AARNCMVAHD | FTVKIGDFGM | TRDIYETDYY | RKGGKGLLPV |
| 1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
| RWMAPESLKD | GVFTTSSDMW | SFGVVLWEIT | SLAEQPYQGL | SNEQVLKFVM | DGGYLDQPDN | CPERVTDLMR | MCWQFNPKMR | PTFLEIVNLL | KDDLHPSFPE |
| 1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | |
| VSFFHSEENK | APESEELEME | FEDMENVPLD | RSSHCQREEA | GGRDGGSSLG | FKRSYEEHIP | YTHMNGGKKN | GRILTLPRSN | PS |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 9 | Smeekens JM, Chen WX, Wu RH: Mass Spectrometric Analysis of the Cell Surface N-Glycoproteome by Combining Metabolic Labeling and Click Chemistry. Journal of the American Society for Mass Spectrometry 2015, 26:604-614. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 15 | Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 18 | Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 38 | Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 50 | Whitmore TE, Peterson A, Holzman T, Eastham A, Amon L, McIntosh M, Ozinsky A, Nelson PS, Martin DB: Integrative Analysis of N-Linked Human Glycoproteomic Data Sets Reveals PTPRF Ectodomain as a Novel Plasma Biomarker Candidate for Prostate Cancer. Journal of Proteome Research 2012, 11:2653-2665. |
| 58 | Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |