Contains      

UniProtKB-P07307

Protein Asialoglycoprotein receptor 2
Gene ASGR2
Status Reviewed
Source HCC cell lines (Liver); HepG2 cell line (Liver); HuH-7 cell line (Liver); Liver; Liver tumor (HCC); Plasma; Prostate; Prostate tumor; Serum; Urine
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
102 SLKEAFSnF 2014(33);
102 RSLKEAFSnF 2014(33);
102 EAFSnFSSSTL 2014(33);
102 AFSnFSSSTLTE 2014(33);
102 EAFSnFSSSTLTE 2014(33);
102 EAFSnFSSSTLTEVQ 2014(33);
102 SnFSSSTLTEVQAISTHGGSVGDK 2014(33);
102 EAFSnFSSSTLTEVQAISTHGGSVGDK 2005( 81); 2009(64); 2010(40); 2013(38); 2013(38); 2013(40); 2014(13); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
102 SLKEAFSnFSSSTLTEVQAISTHGGSVGDK 2014(33);
102 EAFSnFSSSTLTEVQAISTHGGSVGDKITSLGAK 2009(64);
170 LLHSnGSQR 2014(33);
170 HSnGSQRTCCPVNW 2014(33);
170 LHSnGSQRTCCPVNW 2014(33);
170 VACQMELLHSnGSQR 2014(33);
170 FVACQMEIIHSnGSQR 2014(32); 2014(32);
170 FVACQMELLHSnGSQR 2007(64); 2009(38); 2013(38); 2013(38); 2013(40); 2013(42); 2013(45); 2013(13); 2014(14); 2014(33); 2014(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
170 RFVACQMELLHSnGSQR 2014(14);
170 HSnGSQRTCCPVNWVEHQGSCY 2014(33);

Sequence

1112131415161718191
MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAF
101111121131141151161171181191
SNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAE
201211221231241251261271281291
AEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVC
301311
EKRRNATGEVA

Reference

ID Publication
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.