Protein | Beta-hexosaminidase subunit beta |
Gene | HEXB |
Status | Reviewed |
Source | Bladder tumor; Breast Cancer cell lines; Breast cancer cell lines; Breast cell lines; Breast tumor; Cerebrospinal fluid; Colorectal cancer cell line, HCT-116 (colorectal cancer); DLBCL cell lines (Diffuse large B-cell lymphoma); DRO-1 Cell Line (Thyroid Cance); HCCLM3 cell line (Liver); HEK293T cell line (embryonic kidney); HEK293T cell line (embryonic kidney), HEK293T cell line (embryonic kidney); HeLa cell line (Cervical cancer); Hela cell line (cervical cancer); IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; LNCap/PC3 cell lines (Prostate cancer); Liver; LnCap cell line (Prostate cancer); OVCAR-3 cell line (Ovarian cancer); Ovarian cancer cell lines; Ovarian tumor; Pancreatic islets; Prostate; Prostate cancer cell lines; Prostate cancer metastasis to liver; Prostate tumor; Serum; TPC-1 Cell Line (Thyroid Cance); Urine; XTC-1 Cell Line (Thyroid Cance) |
Years | 2003-20072007 |
Site | Identified Peptides | Year(Publication ID) |
---|---|---|
84 | ISHSPnSTAGPSCT | 2009(64); |
84 | ISHSPnSTAGPSCTL | 2014(33); |
84 | NFYISHSPnSTAGPSC | 2014(33); |
84 | nSTAGPSCTLLEEAFR | 2015(1); |
84 | YISHSPnSTAGPSCTL | 2009(64); 2014(33); |
84 | YISHSPnSTAGPSCTLL | 2009(64); |
84 | ISHSPnSTAGPSCTLLEE | 2014(33); |
84 | ISHSPnSTAGPSCTLLEEAF | 2014(33); |
84 | NFYISHSPnSTAGPSCTLLE | 2014(33); |
84 | ISHSPnSTAGPSCTLLEEAFR | 2007(unpublished);2012(48); 2014(33); |
84 | NFYISHSPnSTAGPSCTLLEE | 2014(33); |
84 | YISHSPnSTAGPSCTLLEEAF | 2014(33); |
84 | YISHSPnSTAGPSCTLLEEAFR | 2012(48); 2014(33); |
84 | NFYISHSPnSTAGPSCTLLEEAFR | 2014(33); |
84 | ENFYISHSPnSTAGPSCTLLEEAFR | 2012(48); |
84 | NFYISHSPnSTAGPSCTLLEEAFRR | 2014(33); |
84 | APENFYISHSPnSTAGPSCTLLEEAFR | 2012(48); |
84 | LAPENFYISHSPnSTAGPSCTLLEEAFR | 2012(48); |
84 | LLHLAPENFYISHSPnSTAGPSCTLLEEAFR | 2012(52); 2015(unpublished); |
84 | MTPNLLHLAPENFYISHSPnSTAGPSCTLLEEAFR | 2009(62); 2012(52); 2013(34); 2013(34); 2014(33); 2015(1); 2015(2); 2015(12); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
84 | MTPNIIHIAPENFYISHSPnSTAGPSCTIIEEAFRR | 2014(16); |
84 | MTPNLLHLAPENFYISHSPnSTAGPSCTLLEEAFRR | 2009(62); 2012(52); 2014(33); 2015(2); |
142 | CDAFPnISSDE | 2014(33); |
142 | QSECDAFPnISSDESY | 2014(33); |
190 | SYGTFTInE | 2014(33); |
190 | nESTIIDSPR | 2015(1); |
190 | InESTIIDSPR | 2014(14); 2015(unpublished); |
190 | TInESTIIDSPR | 2012(52); 2014(14); 2014(33); 2015(unpublished); |
190 | TInESTIIDSPRF | 2014(33); |
190 | TInESTIIDSPRFS | 2014(33); |
190 | GTFTInESTIIDSPR | 2014(33); |
190 | TInESTIIDSPRFSH | 2014(33); |
190 | SQLVYQDSYGTFTInESTIIDSPR | 2015(unpublished); |
190 | GLETFSQLVYQDSYGTFTInESTIIDSPR | 2007(75); 2015(2); 2015(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(UnpublishedUnpublished ); 20072007 ; |
327 | GPINPTLnTTY | 2014(33); |
327 | NPTLnTTYSFL | 2014(33); |
327 | nTTYSFLTTFFK | 2015(1); |
327 | LDSFGPINPTLnT | 2014(14); |
327 | PINPTInTTYSFI | 2013(37); |
327 | LDSFGPINPTLnTTY | 2011(57); 2014(33); |
327 | PTLnTTYSFLTTFFK | 2015(unpublished); |
327 | DSFGPINPTLnTTYSF | 2009(64); |
327 | KLDSFGPINPTLnTTY | 2014(33); |
327 | LDSFGPINPTLnTTYSFL | 2011(57); |
327 | IDSFGPINPTInTTYSFITTFFK | 2014(16); |
327 | LDSFGPINPTLnTTYSFLTTFFK | 2003( 83); 2007(62); 2009(62); 2009(63); 2009(64); 2009(67); 2009(58); 2011(33); 2014(2); 2015(9); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007;2007 ; |
327 | KLDSFGPINPTLnTTYSFLTTFFK | 2015(unpublished); |
327 | LDSFGPINPTLnTTYSFLTTFFKE | 2014(33); |
327 | QNKLDSFGPINPTLnTTYSFLTTFFK | 2014(33); 2015(2); |
1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
MELCGLGLPR | PPMLLALLLA | TLLAAMLALL | TQVALVVQVA | EAARAPSVSA | KPGPALWPLP | LSVKMTPNLL | HLAPENFYIS | HSPNSTAGPS | CTLLEEAFRR |
101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
YHGYIFGFYK | WHHEPAEFQA | KTQVQQLLVS | ITLQSECDAF | PNISSDESYT | LLVKEPVAVL | KANRVWGALR | GLETFSQLVY | QDSYGTFTIN | ESTIIDSPRF |
201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
SHRGILIDTS | RHYLPVKIIL | KTLDAMAFNK | FNVLHWHIVD | DQSFPYQSIT | FPELSNKGSY | SLSHVYTPND | VRMVIEYARL | RGIRVLPEFD | TPGHTLSWGK |
301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
GQKDLLTPCY | SRQNKLDSFG | PINPTLNTTY | SFLTTFFKEI | SEVFPDQFIH | LGGDEVEFKC | WESNPKIQDF | MRQKGFGTDF | KKLESFYIQK | VLDIIATINK |
401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
GSIVWQEVFD | DKAKLAPGTI | VEVWKDSAYP | EELSRVTASG | FPVILSAPWY | LDLISYGQDW | RKYYKVEPLD | FGGTQKQKQL | FIGGEACLWG | EYVDATNLTP |
501 | 511 | 521 | 531 | 541 | 551 | ||||
RLWPRASAVG | ERLWSSKDVR | DMDDAYDRLT | RHRCRMVERG | IAAQPLYAGY | CNHENM |
ID | Publication |
---|---|
1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
9 | Smeekens JM, Chen WX, Wu RH: Mass Spectrometric Analysis of the Cell Surface N-Glycoproteome by Combining Metabolic Labeling and Click Chemistry. Journal of the American Society for Mass Spectrometry 2015, 26:604-614. |
12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
57 | Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75. |
58 | Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993. |
62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |
63 | Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672. |
64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |
67 | McDonald CA, Yang JY, Marathe V, Yen T-Y, Macher BA: Combining Results from Lectin Affinity Chromatography and Glycocapture Approaches Substantially Improves the Coverage of the Glycoproteome. Molecular & Cellular Proteomics 2009, 8:287-301. |
75 | Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149. |