Detail

Contains

UniProtKB-P07949


Protein	Proto-oncogene tyrosine-protein kinase receptor Ret
Gene	RET
Status	Reviewed
Source	Breast cancer xenografts; HCC cell lines (Liver); HCCLM3 cell line (Liver); HEK293 cell line (embryonic kidney)
Years	2009-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
336	VEHWPnETSVQANGSFVR	2015(unpublished);
343	VEHWPNETSVQAnGSFVR	2015(unpublished);
361	nLSISENR	2015(unpublished);
367	NLSISEnR	2015(unpublished);
468	FVnDTK	2013(40); 2014(15); 2015(unpublished);
554	nFSTCSPSTK	2015(unpublished);
975	MERPDnCSEEMYR	2009(63);

Sequence

1	11	21	31	41	51	61	71	81	91
MAKATSGAAG	LRLLLLLLLP	LLGKVALGLY	FSRDAYWEKL	YVDQAAGTPL	LYVHALRDAP	EEVPSFRLGQ	HLYGTYRTRL	HENNWICIQE	DTGLLYLNRS
101	111	121	131	141	151	161	171	181	191
LDHSSWEKLS	VRNRGFPLLT	VYLKVFLSPT	SLREGECQWP	GCARVYFSFF	NTSFPACSSL	KPRELCFPET	RPSFRIRENR	PPGTFHQFRL	LPVQFLCPNI
201	211	221	231	241	251	261	271	281	291
SVAYRLLEGE	GLPFRCAPDS	LEVSTRWALD	REQREKYELV	AVCTVHAGAR	EEVVMVPFPV	TVYDEDDSAP	TFPAGVDTAS	AVVEFKRKED	TVVATLRVFD
301	311	321	331	341	351	361	371	381	391
ADVVPASGEL	VRRYTSTLLP	GDTWAQQTFR	VEHWPNETSV	QANGSFVRAT	VHDYRLVLNR	NLSISENRTM	QLAVLVNDSD	FQGPGAGVLL	LHFNVSVLPV
401	411	421	431	441	451	461	471	481	491
SLHLPSTYSL	SVSRRARRFA	QIGKVCVENC	QAFSGINVQY	KLHSSGANCS	TLGVVTSAED	TSGILFVNDT	KALRRPKCAE	LHYMVVATDQ	QTSRQAQAQL
501	511	521	531	541	551	561	571	581	591
LVTVEGSYVA	EEAGCPLSCA	VSKRRLECEE	CGGLGSPTGR	CEWRQGDGKG	ITRNFSTCSP	STKTCPDGHC	DVVETQDINI	CPQDCLRGSI	VGGHEPGEPR
601	611	621	631	641	651	661	671	681	691
GIKAGYGTCN	CFPEEEKCFC	EPEDIQDPLC	DELCRTVIAA	AVLFSFIVSV	LLSAFCIHCY	HKFAHKPPIS	SAEMTFRRPA	QAFPVSYSSS	GARRPSLDSM
701	711	721	731	741	751	761	771	781	791
ENQVSVDAFK	ILEDPKWEFP	RKNLVLGKTL	GEGEFGKVVK	ATAFHLKGRA	GYTTVAVKML	KENASPSELR	DLLSEFNVLK	QVNHPHVIKL	YGACSQDGPL
801	811	821	831	841	851	861	871	881	891
LLIVEYAKYG	SLRGFLRESR	KVGPGYLGSG	GSRNSSSLDH	PDERALTMGD	LISFAWQISQ	GMQYLAEMKL	VHRDLAARNI	LVAEGRKMKI	SDFGLSRDVY
901	911	921	931	941	951	961	971	981	991
EEDSYVKRSQ	GRIPVKWMAI	ESLFDHIYTT	QSDVWSFGVL	LWEIVTLGGN	PYPGIPPERL	FNLLKTGHRM	ERPDNCSEEM	YRLMLQCWKQ	EPDKRPVFAD
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
ISKDLEKMMV	KRRDYLDLAA	STPSDSLIYD	DGLSEEETPL	VDCNNAPLPR	ALPSTWIENK	LYGMSDPNWP	GESPVPLTRA	DGTNTGFPRY	PNDSVYANWM
1101	1111
LSPSAAKLMD	TFDS

Reference

ID	Publication
15	Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
63	Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672.