Contains      

UniProtKB-P12110

Protein Collagen alpha-2(VI) chain
Gene COL6A2
Status Reviewed
Source Bladder tumor; Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Colorectal tumor; HCC cell lines (Liver); HCCLM3 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Platelet; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Saliva; TPC-1 Cell Line (Thyroid Cance); Urine; ovarian tumor
Years 2007-20072007

Glycosites

Site Identified Peptides Year(Publication ID)
140 nMTEQIR 2012(48); 2014(33);
140 AnMTEQIR 2012(48); 2014(33);
140 LAnMTEQIR 2014(33);
140 ALAnMTEQIR 2012(48); 2014(14); 2014(33); 2015(unpublished);
140 CALAnMTEQIR 2014(33);
140 TDCALAnMTEQ 2014(33);
140 RGTFTDCALAnM 2014(33);
140 GTFTDCALAnMTE 2014(33);
140 TDCAIAnMTEQIR 2013(37);
140 TDCALAnMTEQIR 2012(48); 2014(33);
140 FTDCALAnMTEQIR 2012(48);
140 RGTFTDCALAnMTE 2014(33);
140 TDCALAnMTEQIRQ 2014(33);
140 GTFTDCALAnMTEQIR 2009(62); 2009(63); 2009(64); 2011(54); 2012(3); 2012(48); 2012(52); 2013(34); 2013(40); 2014(14); 2014(22); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2015;2007;2007;2007;20072007 ;
140 RGTFTDCALAnMTEQI 2012(48);
140 TDCALAnMTEQIRQDR 2014(33);
140 RGTFTDCAIAnMTEQIR 2014(32);
140 RGTFTDCALAnMTEQIR 2009(64); 2012(48); 2013(34); 2014(14); 2014(19); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);
140 RRGTFTDCALAnMTEQIR 2014(33);
140 FRRGTFTDCALAnMTEQIR 2014(33);
140 GTFTDCALAnMTEQIRQDR 2014(14); 2014(18); 2014(33); 2015(unpublished);
140 TDCALAnMTEQIRQDRSKG 2014(33);
140 RGTFTDCALAnMTEQIRQDR 2014(33);
140 TDCALAnMTEQIRQDRSKGTVHF 2014(33);
140 QGISSFRRGTFTDCALAnMTEQIR 2014(33);
630 SIGYTnF 2014(33);
630 TnFTLEK 2014(33);
630 GYTnFTLEK 2014(14); 2015(unpublished);2007(unpublished);2007;
630 TnFTLEKNF 2014(33);
630 IGYTnFTLEK 2014(33);
630 SIGYTnFTLE 2014(33);
630 SIGYTnFTLEK 2014(33); 2015(unpublished);
630 SESIGYTnFTLEK 2014(14); 2014(33); 2015(unpublished);
630 VIDSSESIGYTnF 2014(33);
630 SSESIGYTnFTLEK 2014(33); 2015(unpublished);
630 DSSESIGYTnFTLEK 2012(48); 2015(unpublished);
630 VIDSSESIGYTnFTLE 2014(33);
630 VIDSSESIGYTnFTLEK 2014(33); 2015(unpublished);
630 FVIDSSESIGYTnFTLEK 2015(unpublished);
630 CGAIDVVFVIDSSESIGYTnFTIEK 2014(32); 2014(32);
630 VIDSSESIGYTnFTLEKNFVINVVNR 2014(33);
785 nMTLF 2014(33);
785 nMTLFSD 2014(33);
785 nMTLFSDL 2014(33);
785 nMTLFSDLV 2014(33);
785 nMTLFSDLVAE 2014(33);
785 nMTLFSDLVAEK 2009(63); 2009(64); 2011(54); 2011(55); 2011(56); 2012(48); 2012(52); 2013(34); 2013(40); 2014(14); 2014(22); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
785 KPQQVRnMTIFSD 2013(37);
785 SIACDKPQQVRnM 2014(33);
785 VRnMTLFSDLVAEK 2014(33);
785 SIACDKPQQVRnMTL 2014(33);
785 SIACDKPQQVRnMTLF 2014(33);
785 YSIACDKPQQVRnMTLFSDLVAEK 2014(33);
897 SHnLTAIH 2014(33);
897 SHnLTAIHE 2014(33);
897 SHnLTAIHEAL 2014(33);
897 PLSHnLTAIHEAL 2009(64);
897 VAFPLSHnLTAIHE 2014(33);
897 QQVAFPLSHnLTAIHE 2014(33);
897 SHnLTAIHEALETTQY 2014(33);
897 GPGEQQVAFPLSHnLTAIHE 2014(33);
897 SHnLTAIHEALETTQYLNSF 2014(33);
897 GGPGEQQVAFPLSHnLTAIHE 2014(33);
897 FGGPGEQQVAFPLSHnLTAIHE 2014(33);
897 QFGGPGEQQVAFPLSHnLTAIHE 2014(33);
897 VALLQFGGPGEQQVAFPLSHnLTAIH 2014(33); 2015(unpublished);
897 VALLQFGGPGEQQVAFPLSHnLTAIHE 2014(33);
897 QFGGPGEQQVAFPLSHnLTAIHEALETTQY 2014(33);
897 HnLTAIHEALETTQYLNSFSHVGAGVVHAINAIVR 2015(unpublished);
897 VALLQFGGPGEQQVAFPLSHnLTAIHEALETTQYLNSFSH 2015(unpublished);
897 VALLQFGGPGEQQVAFPLSHnLTAIHEALETTQYLNSFSHVGAGVVH 2015(unpublished);
897 VALLQFGGPGEQQVAFPLSHnLTAIHEALETTQYLNSFSHVGAGVVHAIN 2015(unpublished);
954 GVTGnDSLHE 2014(33);
954 LTDGVTGnDSL 2009(64);
954 nDSLHESAHSMR 2015(1);
954 TDGVTGnDSLHE 2014(33);
954 LTDGVTGnDSLHE 2009(64); 2014(33);
954 VTGnDSLHESAHS 2009(64);
954 FLTDGVTGnDSLHE 2014(33);
954 LTDGVTGnDSLHES 2009(64);
954 TGnDSLHESAHSMR 2014(14); 2015(unpublished);
954 VFLTDGVTGnDSLH 2014(33);
954 TDGVTGnDSLHESAH 2014(33);
954 VFLTDGVTGnDSLHE 2014(33);
954 FVFLTDGVTGnDSLHE 2014(33);
954 LTDGVTGnDSLHESAH 2014(33);
954 LTDGVTGnDSLHESAHS 2014(33);
954 SFVFLTDGVTGnDSLHE 2014(33);
954 TDGVTGnDSLHESAHSM 2014(33);
954 LSFVFLTDGVTGnDSLHE 2014(33);
954 LTDGVTGnDSLHESAHSM 2014(33);
954 TDGVTGnDSLHESAHSMR 2014(14); 2014(33); 2015(unpublished);
954 VFLTDGVTGnDSLHESAH 2014(33);
954 ELSFVFLTDGVTGnDSLHE 2014(33);
954 LTDGVTGnDSLHESAHSMR 2014(14); 2014(33); 2015(unpublished);
954 FLTDGVTGnDSLHESAHSMR 2012(48); 2014(33); 2015(unpublished);
954 LTDGVTGnDSLHESAHSMRK 2014(14);
954 SFVFLTDGVTGnDSLHESAH 2014(33);
954 VFLTDGVTGnDSLHESAHSM 2014(33);
954 VFLTDGVTGnDSLHESAHSMR 2014(14); 2014(33); 2015(unpublished);

Sequence

1112131415161718191
MLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNEFYLDQVALSWRYGGLH
101111121131141151161171181191
FSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNQNLKEQG
201211221231241251261271281291
LRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPK
301311321331341351361371381391
GVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSG
401411421431441451461471481491
APGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGD
501511521531541551561571581591
SGQPGPKGDPGRPGFSYPGPRGAPGEKGEPGPRGPEGGRGDFGLKGEPGRKGEKGEPADPGPPGEPGPRGPRGVPGPEGEPGPPGDPGLTECDVMTYVRE
601611621631641651661671681691
TCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDERIDSLSSFKEAVKNLEWIAGG
701711721731741751761771781791
TWTPSALKFAYDRLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHEKHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDD
801811821831841851861871881891
MEDVLCPDPQIVCPDLPCQTELSVAQCTQRPVDIVFLLDGSERLGEQNFHKARRFVEQVARRLTLARRDDDPLNARVALLQFGGPGEQQVAFPLSHNLTA
901911921931941951961971981991
IHEALETTQYLNSFSHVGAGVVHAINAIVRSPRGGARRHAELSFVFLTDGVTGNDSLHESAHSMRKQNVVPTVLALGSDVDMDVLTTLSLGDRAAVFHEK
10011011
DYDSLAQPGFFDRFIRWIC

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
3Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
19Huang G, Sun Z, Qin H, Zhao L, Xiong Z, Peng X, Ou J, Zou H: Preparation of hydrazine functionalized polymer brushes hybrid magnetic nanoparticles for highly specific enrichment of glycopeptides. Analyst 2014, 139:2199-2206.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
55Tian Y, Bova GS, Zhang H: Quantitative glycoproteomic analysis of optimal cutting temperature-embedded frozen tissues identifying glycoproteins associated with aggressive prostate cancer. Analytical chemistry 2011, 83:7013-7019.
56Bandhakavi S, Van Riper SK, Tawfik PN, Stone MD, Haddad T, Rhodus NL, Carlis JV, Griffin TJ: Hexapeptide Libraries for Enhanced Protein PTM Identification and Relative Abundance Profiling in Whole Human Saliva. Journal of Proteome Research 2011, 10:1052-1061.
62Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968.
63Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.