Contains      

UniProtKB-P12111

Protein Collagen alpha-3(VI) chain
Gene COL6A3
Status Reviewed
Source Breast Cancer cell lines; Breast cancer xenografts; Breast tumor; Cerebrospinal fluid; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; Colorectal tumors; HCC cell lines (Liver); Liver; Liver tumor (HCC); Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate tumor; Serum; Urine; ovarian tumor
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
108 VLSHISnMSYIGGTNQTGK 2014(33);
108 QEVLSHISnMSYIGGTNQTGK 2007(33); 2014(unpublished);2015(unpublished);2015;2015;2007;2007;
108 TKQEVLSHISnMSYIGGTNQTGK 2014(13); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
116 IGGTnQTGKGLEY 2014(33);
116 VLSHISNMSYIGGTnQTGK 2014(33);
116 QEVLSHISNMSYIGGTnQTGK 2007(33); 2014(unpublished);2015(unpublished);2015;2015;2007;2007;
116 TKQEVLSHISNMSYIGGTnQTGK 2014(13); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
202 EIASEPLNMHMFNLEnFTSLHDIVGNLVSCVHSSVSPER 2015(unpublished);
251 LIDGSnNTGSVNF 2014(33);
2079 GPPGVnGTQGF 2014(33);
2079 RGPPGVnGTQGF 2014(33);
2079 GPPGVnGTQGFQG 2014(33);
2079 GERGPPGVnGTQGF 2014(33);
2079 GPPGVnGTQGFQGCPGQR 2009(64); 2011(54); 2011(58); 2012(3); 2012(48); 2013(34); 2013(40); 2014(22); 2014(32); 2014(32); 2014(33); 2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;
2079 RGYPGDEGGPGERGPPGVnGTQGF 2014(33);
2079 GYPGDEGGPGERGPPGVnGTQGFQGCPGQR 2014(33);
2079 IGPKGIPGEDGYRGYPGDEGGPGERGPPGVnGTQG 2009(64);
2331 PGEPGLnGTTGPK 2012(48); 2015(unpublished);
2331 GNPGEPGLnGTTGPK 2011(54); 2012(48); 2014(14); 2014(22); 2014(33); 2015(unpublished);2007(unpublished);2007;
2331 GFPGYPGPKGNPGEPGLnGTTGPK 2009(68);
2558 QInNTAVGH 2014(33);
2558 ALQInNTAVGH 2014(33);
2558 QInNTAVGHAL 2014(33);
2558 NALQInNTAVGH 2014(33);
2558 ALQInNTAVGHAL 2014(33);
2558 INALQInNTAVGH 2014(33);
2558 NALQInNTAVGHAL 2014(33);
2558 INALQInNTAVGHAL 2014(33);
2558 QLINALQInNTAVGH 2011(54); 2012(48); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);
2558 QInNTAVGHALVLPAGR 2014(33);
2558 QLINALQInNTAVGHAL 2014(33); 2015(unpublished);
2558 ALQInNTAVGHALVLPAGR 2012(48); 2014(33); 2015(unpublished);
2558 LTRQEDRQLINALQInNTAVGH 2014(33);
2558 QIINAIQInNTAVGHAIVIPAGR 2014(32); 2014(32);
2558 QLINALQInNTAVGHALVLPAGR 2009(68); 2012(48); 2014(33); 2015(unpublished);2015(unpublished);2015;2007;2007;
2558 DRQLINALQInNTAVGHALVLPAGR 2014(33);
2677 SVDnASMPPVK 2012(48);
2677 APSESVDnASMPPVK 2012(48);
2677 HAPSESVDnASMPPVK 2015(unpublished);
2677 VAVVQHAPSESVDnASM 2012(48);
2677 VQHAPSESVDnASMPPVK 2012(48);
2677 HAPSESVDnASMPPVKVEF 2014(33);
2677 VVQHAPSESVDnASMPPVK 2012(48); 2015(unpublished);
2677 VAVVQHAPSESVDnASMPPVK 2005( 81); 2007(64); 2009(40); 2010(54); 2011(48); 2012(34); 2013(40); 2013(13); 2014(14); 2014(22); 2014(32); 2014(33); 2014(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;2007;2007;2007;
2677 VAVVQHAPSESVDnASMPPVKVE 2014(33);
2677 ARVAVVQHAPSESVDnASMPPVKVEF 2014(33);
2677 VAVVQHAPSESVDnASMPPVKVEFSLTDYGSK 2013(34);
3037 QnLTVTDR 2007(40); 2013(45); 2013(14); 2014(22); 2014(33); 2014(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
3037 KQnLTVTDR 2015(unpublished);
3037 SIVIKQnITVTDR 2013(37);
3037 KQnLTVTDRVIGGLL 2014(33);

Sequence

1112131415161718191
MRKHRHLPLVAVFCLFLSGFPTTHAQQQQADVKNGAAADIIFLVDSSWTIGEEHFQLVREFLYDVVKSLAVGENDFHFALVQFNGNPHTEFLLNTYRTKQ
101111121131141151161171181191
EVLSHISNMSYIGGTNQTGKGLEYIMQSHLTKAAGSRAGDGVPQVIVVLTDGHSKDGLALPSAELKSADVNVFAIGVEDADEGALKEIASEPLNMHMFNL
201211221231241251261271281291
ENFTSLHDIVGNLVSCVHSSVSPERAGDTETLKDITAQDSADIIFLIDGSNNTGSVNFAVILDFLVNLLEKLPIGTQQIRVGVVQFSDEPRTMFSLDTYS
301311321331341351361371381391
TKAQVLGAVKALGFAGGELANIGLALDFVVENHFTRAGGSRVEEGVPQVLVLISAGPSSDEIRYGVVALKQASVFSFGLGAQAASRAELQHIATDDNLVF
401411421431441451461471481491
TVPEFRSFGDLQEKLLPYIVGVAQRHIVLKPPTIVTQVIEVNKRDIVFLVDGSSALGLANFNAIRDFIAKVIQRLEIGQDLIQVAVAQYADTVRPEFYFN
501511521531541551561571581591
THPTKREVITAVRKMKPLDGSALYTGSALDFVRNNLFTSSAGYRAAEGIPKLLVLITGGKSLDEISQPAQELKRSSIMAFAIGNKGADQAELEEIAFDSS
601611621631641651661671681691
LVFIPAEFRAAPLQGMLPGLLAPLRTLSGTPEVHSNKRDIIFLLDGSANVGKTNFPYVRDFVMNLVNSLDIGNDNIRVGLVQFSDTPVTEFSLNTYQTKS
701711721731741751761771781791
DILGHLRQLQLQGGSGLNTGSALSYVYANHFTEAGGSRIREHVPQLLLLLTAGQSEDSYLQAANALTRAGILTFCVGASQANKAELEQIAFNPSLVYLMD
801811821831841851861871881891
DFSSLPALPQQLIQPLTTYVSGGVEEVPLAQPESKRDILFLFDGSANLVGQFPVVRDFLYKIIDELNVKPEGTRIAVAQYSDDVKVESRFDEHQSKPEIL
901911921931941951961971981991
NLVKRMKIKTGKALNLGYALDYAQRYIFVKSAGSRIEDGVLQFLVLLVAGRSSDRVDGPASNLKQSGVVPFIFQAKNADPAELEQIVLSPAFILAAESLP
1001101110211031104110511061107110811091
KIGDLHPQIVNLLKSVHNGAPAPVSGEKDVVFLLDGSEGVRSGFPLLKEFVQRVVESLDVGQDRVRVAVVQYSDRTRPEFYLNSYMNKQDVVNAVRQLTL
1101111111211131114111511161117111811191
LGGPTPNTGAALEFVLRNILVSSAGSRITEGVPQLLIVLTADRSGDDVRNPSVVVKRGGAVPIGIGIGNADITEMQTISFIPDFAVAIPTFRQLGTVQQV
1201121112211231124112511261127112811291
ISERVTQLTREELSRLQPVLQPLPSPGVGGKRDVVFLIDGSQSAGPEFQYVRTLIERLVDYLDVGFDTTRVAVIQFSDDPKVEFLLNAHSSKDEVQNAVQ
1301131113211331134113511361137113811391
RLRPKGGRQINVGNALEYVSRNIFKRPLGSRIEEGVPQFLVLISSGKSDDEVDDPAVELKQFGVAPFTIARNADQEELVKISLSPEYVFSVSTFRELPSL
1401141114211431144114511461147114811491
EQKLLTPITTLTSEQIQKLLASTRYPPPAVESDAADIVFLIDSSEGVRPDGFAHIRDFVSRIVRRLNIGPSKVRVGVVQFSNDVFPEFYLKTYRSQAPVL
1501151115211531154115511561157115811591
DAIRRLRLRGGSPLNTGKALEFVARNLFVKSAGSRIEDGVPQHLVLVLGGKSQDDVSRFAQVIRSSGIVSLGVGDRNIDRTELQTITNDPRLVFTVREFR
1601161116211631164116511661167116811691
ELPNIEERIMNSFGPSAATPAPPGVDTPPPSRPEKKKADIVFLLDGSINFRRDSFQEVLRFVSEIVDTVYEDGDSIQVGLVQYNSDPTDEFFLKDFSTKR
1701171117211731174117511761177117811791
QIIDAINKVVYKGGRHANTKVGLEHLRVNHFVPEAGSRLDQRVPQIAFVITGGKSVEDAQDVSLALTQRGVKVFAVGVRNIDSEEVGKIASNSATAFRVG
1801181118211831184118511861187118811891
NVQELSELSEQVLETLHDAMHETLCPGVTDAAKACNLDVILGFDGSRDQNVFVAQKGFESKVDAILNRISQMHRVSCSGGRSPTVRVSVVANTPSGPVEA
1901191119211931194119511961197119811991
FDFDEYQPEMLEKFRNMRSQHPYVLTEDTLKVYLNKFRQSSPDSVKVVIHFTDGADGDLADLHRASENLRQEGVRALILVGLERVVNLERLMHLEFGRGF
2001201120212031204120512061207120812091
MYDRPLRLNLLDLDYELAEQLDNIAEKACCGVPCKCSGQRGDRGPIGSIGPKGIPGEDGYRGYPGDEGGPGERGPPGVNGTQGFQGCPGQRGVKGSRGFP
2101211121212131214121512161217121812191
GEKGEVGEIGLDGLDGEDGDKGLPGSSGEKGNPGRRGDKGPRGEKGERGDVGIRGDPGNPGQDSQERGPKGETGDLGPMGVPGRDGVPGGPGETGKNGGF
2201221122212231224122512261227122812291
GRRGPPGAKGNKGGPGQPGFEGEQGTRGAQGPAGPAGPPGLIGEQGISGPRGSGGAAGAPGERGRTGPLGRKGEPGEPGPKGGIGNRGPRGETGDDGRDG
2301231123212331234123512361237123812391
VGSEGRRGKKGERGFPGYPGPKGNPGEPGLNGTTGPKGIRGRRGNSGPPGIVGQKGDPGYPGPAGPKGNRGDSIDQCALIQSIKDKCPCCYGPLECPVFP
2401241124212431244124512461247124812491
TELAFALDTSEGVNQDTFGRMRDVVLSIVNDLTIAESNCPRGARVAVVTYNNEVTTEIRFADSKRKSVLLDKIKNLQVALTSKQQSLETAMSFVARNTFK
2501251125212531254125512561257125812591
RVRNGFLMRKVAVFFSNTPTRASPQLREAVLKLSDAGITPLFLTRQEDRQLINALQINNTAVGHALVLPAGRDLTDFLENVLTCHVCLDICNIDPSCGFG
2601261126212631264126512661267126812691
SWRPSFRDRRAAGSDVDIDMAFILDSAETTTLFQFNEMKKYIAYLVRQLDMSPDPKASQHFARVAVVQHAPSESVDNASMPPVKVEFSLTDYGSKEKLVD
2701271127212731274127512761277127812791
FLSRGMTQLQGTRALGSAIEYTIENVFESAPNPRDLKIVVLMLTGEVPEQQLEEAQRVILQAKCKGYFFVVLGIGRKVNIKEVYTFASEPNDVFFKLVDK
2801281128212831284128512861287128812891
STELNEEPLMRFGRLLPSFVSSENAFYLSPDIRKQCDWFQGDQPTKNLVKFGHKQVNVPNNVTSSPTSNPVTTTKPVTTTKPVTTTTKPVTTTTKPVTII
2901291129212931294129512961297129812991
NQPSVKPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPAAAAAKPVATKPEVPRPQAAKPAATKPATTKPMVKMSREVQVFEI
3001301130213031304130513061307130813091
TENSAKLHWERAEPPGPYFYDLTVTSAHDQSLVLKQNLTVTDRVIGGLLAGQTYHVAVVCYLRSQVRATYHGSFSTKKSQPPPPQPARSASSSTINLMVS
31013111312131313141315131613171
TEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVLAKPGVISVMGT

Reference

ID Publication
3Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
68Zhang L, Xu Y, Yao H, Xie L, Yao J, Lu H, Yang P: Boronic Acid Functionalized Core-Satellite Composite Nanoparticles for Advanced Enrichment of Glycopeptides and Glycoproteins. Chemistry-a European Journal 2009, 15:10158-10166.