Contains      

UniProtKB-P12259

Protein Coagulation factor V
Gene F5
Status Reviewed
Source Breast cancer xenografts; Breast tumor; Cerebrospinal fluid; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HepG2 cell line (Liver); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Lung Adenocarcinoma; Non-small Cell Lung Carcinoma; Ovarian tumor; Plasma; Platelet; Prostate; Prostate tumor; Serum; Serum (HCC); Urine; lung; plasma
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
51 RPEPTnSSLNLSVTSF 2014(33);
51 SYRPEPTnSSLNLSVTSFK 2014(33);
51 QFYVAAQGISWSYRPEPTnSSLNLSVTSFK 2015(unpublished);2015(unpublished);2007;2007;
55 RPEPTNSSLnLSVTSF 2014(33);
55 SYRPEPTNSSLnLSVTSFK 2014(33);
55 QFYVAAQGISWSYRPEPTNSSLnLSVTSFK 2015(unpublished);2015(unpublished);2007;2007;
297 VSATSTTAnMTVGPEGKW 2014(33);
297 VSAITLVSATSTTAnMTVGPEGK 2005( 81); 2010(40); 2014(13); 2014(14); 2014(35); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;2007;
460 VnSSFTSGR 2014(33);
460 SPYEDEVnSSF 2014(33);
460 SIYPHGVTFSPYEDEVnSSFTSGR 2014(33);
460 PYSIYPHGVTFSPYEDEVnSSFTSGR 2005(81); 2013(42); 2014(33); 2015(unpublished);
460 NMASRPYSIYPHGVTFSPYEDEVnSSFTSGR 2013(38); 2013(38); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007;2007;
460 NMASRPYSIYPHGVTFSPYEDEVnSSFTSGRNNTMIR 2013(38); 2015(unpublished);
468 nNTMIR 2013(38); 2013(40); 2014(33); 2015(unpublished);
468 NMASRPYSIYPHGVTFSPYEDEVNSSFTSGRnNTMIR 2013(38); 2015(unpublished);
554 AADIEQQAVFAVFDEnK 2013(42);
667 VGTWMLTSMnSSPR 2007(unpublished);
741 RnSSLNQEEEEFNLTAL 2014(33);
752 FnLTALALE 2014(33);
752 EFnLTALALE 2014(33);
752 RNSSLNQEEEEFnLTAL 2014(33);
782 SSPSnISKF 2014(33);
821 NSVLnSSTAE 2014(33);
821 NSVLnSSTAEH 2014(14); 2015(unpublished);
821 SVLnSSTAEHSSPY 2014(33);
821 NSVInSSTAEHSSPYSEDPIEDPIQPDVTGIR 2014(16); 2014(32);
821 NSVLnSSTAEHSSPYSEDPIEDPLQPDVTGIR 2005( 81); 2012(53); 2013(38); 2013(38); 2013(39); 2013(42); 2013(45); 2014(13); 2014(35); 2014(36); 2014(18); 2014(24); 2014(33); 2015(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;
821 HLIGKNSVLnSSTAEHSSPYSEDPIEDPLQPDVTGIR 2013(38); 2015(unpublished);
821 NSVLnSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFK 2013(38);
938 LLKQSnSSKIL 2014(33);
977 LISPQnASRAW 2014(33);
977 LISPQnASRAWGESTPL 2014(33);
977 DTAVNNWLISPQnASRAWGE 2013(42);
977 IIQDTDEDTAVNNWLISPQnASR 2014(33);
977 GSYEIIQDTDEDTAVNNWIISPQnASR 2014(32);
977 GSYEIIQDTDEDTAVNNWLISPQnASR 2005( 81); 2014(33); 2015(unpublished);2015(unpublished);2007;2007;
977 GSYEIIQDTDEDTAVNNWLISPQnASRAWGESTPLANKPGK 2015(unpublished);
1083 TSLPTDLnQTLPSMD 2014(33);
1499 LGQMPSPSSPTLnDTFLSK 2014(33);
1499 SFPYPDLGQMPSPSSPTLnDTFLSK 2014(33);
1559 TNInSSR 2015(unpublished);2015(unpublished);
1559 TNInSSRDPDNIAAW 2014(33);
1559 TNInSSRDPDNIAAWY 2014(33);
1559 TNInSSRDPDNIAAWYIR 2014(16);
1559 TNInSSRDPDNIAAWYLR 2005( 81); 2010(59); 2013(38); 2013(38); 2013(45); 2014(18); 2015(unpublished);2007(unpublished);2007;
1559 TDVRTNInSSRDPDNIAAWYLR 2013(38);
1703 KEDNAVQPnSSY 2014(33);
1703 DNAVQPnSSYTYVWHATE 2013(42);
1703 DNAVQPnSSYTYVWHATER 2014(33);
1703 EDNAVQPnSSYTYVWHATER 2013(38); 2013(38); 2013(40); 2014(13); 2014(32); 2014(33); 2015(unpublished);2015(unpublished);
1703 EDNAVQPnSSYTYVWHATERSGPESPGSACR 2013(38); 2013(38);
1703 TYEDDSPEWFKEDNAVQPnSSYTYVWHATER 2014(16); 2014(33); 2015(unpublished);2015(unpublished);2007;2007;
1703 SSEGKTYEDDSPEWFKEDNAVQPnSSYTYVWHATER 2015(unpublished);
2209 TWnQSIALR 2007(71); 2013(38); 2013(40); 2013(42); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2015;2007;2007;

Sequence

1112131415161718191
MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKV
101111121131141151161171181191
HFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTE
201211221231241251261271281291
GGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTV
301311321331341351361371381391
GPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYE
401411421431441451461471481491
DESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQC
501511521531541551561571581591
LTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTL
601611621631641651661671681691
GFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPE
701711721731741751761771781791
STVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSH
801811821831841851861871881891
QQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGS
901911921931941951961971981991
PSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPK
1001101110211031104110511061107110811091
FPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDH
1101111111211131114111511161117111811191
NQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELS
1201121112211231124112511261127112811291
QTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSH
1301131113211331134113511361137113811391
MTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQI
1401141114211431144114511461147114811491
PLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLND
1501151115211531154115511561157115811591
TFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRE
1601161116211631164116511661167116811691
TDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAV
1701171117211731174117511761177117811791
QPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMK
1801181118211831184118511861187118811891
KSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPF
1901191119211931194119511961197119811991
LIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSN
2001201120212031204120512061207120812091
QINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFR
2101211121212131214121512161217121812191
ARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRF
220122112221
IRVIPKTWNQSIALRLELFGCDIY

Reference

ID Publication
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
24Song E, Zhu R, Hammond ZT, Mechref Y: LC-MS/MS Quantitation of Esophagus Disease Blood Serum Glycoproteins by Enrichment with Hydrazide Chemistry and Lectin Affinity Chromatography. Journal of Proteome Research 2014, 13:4808-4820.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
35Chen J, Shah P, Zhang H: Solid phase extraction of N-linked glycopeptides using hydrazide tip. Analytical chemistry 2013, 85:10670-10674.
36Li QK, Shah P, Li Y, Aiyetan PO, Chen J, Yung R, Molena D, Gabrielson E, Askin F, Chan DW: Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma. Journal of proteome research 2013, 12:3689-3696.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
39Li QK, Shah P, Li Y, Aiyetan PO, Chen J, Yung R, Molena D, Gabrielson E, Askin F, Chan DW, Zhang H: Glycoproteomic Analysis of Bronchoalveolar Lavage (BAL) Fluid Identifies Tumor-Associated Glycoproteins from Lung Adenocarcinonna. Journal of Proteome Research 2013, 12:3689-3696.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
53Zhu J, Wang F, Chen R, Cheng K, Xu B, Guo Z, Liang X, Ye M, Zou H: Centrifugation Assisted Microreactor Enables Facile Integration of Trypsin Digestion, Hydrophilic Interaction Chromatography Enrichment, and On-Column Deglycosylation for Rapid and Sensitive N-Glycoproteome Analysis. Analytical Chemistry 2012, 84:5146-5153.
59Lee H-J, Na K, Choi E-Y, Kim KS, Kim H, Paik Y-K: Simple Method for Quantitative Analysis of N-Linked Glycoproteins in Hepatocellular Carcinoma Specimens. Journal of Proteome Research 2010, 9:308-318.
71Hagglund P, Matthiesen R, Elortza F, Hojrup P, Roepstorff P, Jensen ON, Bunkenborg J: An enzymatic deglycosylation scheme enabling identification of core fucosylated N-glycans and O-glycosylation site mapping of human plasma proteins. Journal of Proteome Research 2007, 6:3021-3031.
81Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Journal of Proteome Research 2005, 4:2070-2080.