Contains      

UniProtKB-P12643

Protein Bone morphogenetic protein 2
Gene BMP2
Status Reviewed
Source HCC cell lines (Liver); HuH-7 cell line (Liver); OVCAR-3 cell line (Ovarian cancer); Prostate
Years 2013-2015

Glycosites

Site Identified Peptides Year(Publication ID)
135 RFFFnLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHR 2013(38);
163 EQMQDALGnNSSFHHR 2013(40);
163 RFFFNLSSIPTEEFITSAELQVFREQMQDALGnNSSFHHR 2013(38);
164 EQMQDALGNnSSFHHR 2013(40);
164 RFFFNLSSIPTEEFITSAELQVFREQMQDALGNnSSFHHR 2013(38);
200 LVNQnASR 2013(40); 2014(14);
200 LVNQnASRWESFDVTPAVMR 2013(38);
338 nSTNHAIVQTLVNSV 2015(1);

Sequence

1112131415161718191
MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLE
101111121131141151161171181191
RAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQN
201211221231241251261271281291
ASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHP
301311321331341351361371381391
LYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.