| Protein | Integrin alpha-4 |
| Gene | ITGA4 |
| Status | Reviewed |
| Source | Breast cancer xenografts; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); Hela cell line (cervical cancer); Jurkat T cell line; Liver; Lymphocytes; Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Ovarian tumorJurkat T cell line; Prostate tumor; Urine |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 79 | nASVINPGAIYR | 2015(1); |
| 79 | LAnASVINPGAIYR | 2007(unpublished);2007(unpublished); |
| 79 | WIIVGAPTANWIAnASVINPGAIYR | 2014(16); |
| 79 | WLLVGAPTANWLAnASVINPGAIYR | 2014(33); 2015(unpublished); |
| 138 | QPGEnGSIVTCGHR | 2014(13); 2014(16); 2014(18); 2014(33); 2015(unpublished);2015(12); |
| 229 | VYnITTNKY | 2014(33); |
| 229 | GSLFVYnITTNK | 2007(unpublished); |
| 229 | DLIVMGAPGSSYWTGSLFVYnITTNK | 2015(unpublished); |
| 480 | TRPVVIVDASISHPESVnR | 2014(16); |
| 480 | TRPVVIVDASLSHPESVnR | 2013(34); 2014(13); 2014(33); 2015(unpublished);2007(unpublished);2007; |
| 518 | YnMSLDVNR | 2007(unpublished);2007(unpublished); |
| 518 | EVPGYIVLFYnMSLDVNR | 2015(unpublished); |
| 538 | FYFSSnGTSDVITGSIQVSSR | 2007(unpublished);2007(unpublished);2007(unpublished);2007; |
| 626 | FCAHEnCSADIQVSAK | 2014(16); |
| 626 | FCAHEnCSADLQVSAK | 2014(22); 2007(unpublished);2007(unpublished); |
| 645 | IGFLKPHEnK | 2014(13); 2015(unpublished);2007(unpublished);2007; |
| 645 | IGFIKPHEnKTYIAVGSMK | 2014(16); |
| 660 | TLMLnVSLFNAGDDAYETTLHVK | 2015(unpublished); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MAWEARREPG | PRRAAVRETV | MLLLCLGVPT | GRPYNVDTES | ALLYQGPHNT | LFGYSVVLHS | HGANRWLLVG | APTANWLANA | SVINPGAIYR | CRIGKNPGQT |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| CEQLQLGSPN | GEPCGKTCLE | ERDNQWLGVT | LSRQPGENGS | IVTCGHRWKN | IFYIKNENKL | PTGGCYGVPP | DLRTELSKRI | APCYQDYVKK | FGENFASCQA |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| GISSFYTKDL | IVMGAPGSSY | WTGSLFVYNI | TTNKYKAFLD | KQNQVKFGSY | LGYSVGAGHF | RSQHTTEVVG | GAPQHEQIGK | AYIFSIDEKE | LNILHEMKGK |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| KLGSYFGASV | CAVDLNADGF | SDLLVGAPMQ | STIREEGRVF | VYINSGSGAV | MNAMETNLVG | SDKYAARFGE | SIVNLGDIDN | DGFEDVAIGA | PQEDDLQGAI |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| YIYNGRADGI | SSTFSQRIEG | LQISKSLSMF | GQSISGQIDA | DNNGYVDVAV | GAFRSDSAVL | LRTRPVVIVD | ASLSHPESVN | RTKFDCVENG | WPSVCIDLTL |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| CFSYKGKEVP | GYIVLFYNMS | LDVNRKAESP | PRFYFSSNGT | SDVITGSIQV | SSREANCRTH | QAFMRKDVRD | ILTPIQIEAA | YHLGPHVISK | RSTEEFPPLQ |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| PILQQKKEKD | IMKKTINFAR | FCAHENCSAD | LQVSAKIGFL | KPHENKTYLA | VGSMKTLMLN | VSLFNAGDDA | YETTLHVKLP | VGLYFIKILE | LEEKQINCEV |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| TDNSGVVQLD | CSIGYIYVDH | LSRIDISFLL | DVSSLSRAEE | DLSITVHATC | ENEEEMDNLK | HSRVTVAIPL | KYEVKLTVHG | FVNPTSFVYG | SNDENEPETC |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| MVEKMNLTFH | VINTGNSMAP | NVSVEIMVPN | SFSPQTDKLF | NILDVQTTTG | ECHFENYQRV | CALEQQKSAM | QTLKGIVRFL | SKTDKRLLYC | IKADPHCLNF |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| LCNFGKMESG | KEASVHIQLE | GRPSILEMDE | TSALKFEIRA | TGFPEPNPRV | IELNKDENVA | HVLLEGLHHQ | RPKRYFTIVI | ISSSLLLGLI | VLLLISYVMW |
| 1001 | 1011 | 1021 | 1031 | ||||||
| KAGFFKRQYK | SILQEENRRD | SWSYINSKSN | DD |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 18 | Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |