Contains      

UniProtKB-P13747

Protein HLA class I histocompatibility antigen, alpha chain E
Gene HLA-E
Status Reviewed
Source Breast Cancer cell lines; DLBCL cell lines (Diffuse large B-cell lymphoma); HEK293T cell line (embryonic kidney); Liver; Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; ovarian tumor
Years 2009-2015

Glycosites

Site Identified Peptides Year(Publication ID)
107 YYnQSE 2014(33);
107 GYYnQSE 2014(33);
107 LRGYYnQSE 2009(64);
107 nQSEAGSHTI 2014(33);
107 nQSEAGSHTL 2014(33);
107 GYYnQSEAGSH 2011(54); 2011(57); 2014(33);
107 nQSEAGSHTLQ 2014(33);
107 YYnQSEAGSHT 2014(14);
107 nQSEAGSHTLQW 2014(33);
107 RGYYnQSEAGSH 2014(33);
107 GYYnQSEAGSHTI 2012(48); 2014(14); 2014(33); 2015(unpublished);
107 GYYnQSEAGSHTL 2014(33); 2015(unpublished);
107 TIRGYYnQSEAGS 2013(37);
107 GYYnQSEAGSHTIQ 2012(48);
107 GYYnQSEAGSHTLQ 2011(57); 2014(33);
107 LRGYYnQSEAGSHT 2009(64);
107 RGYYnQSEAGSHTI 2014(33);
107 RGYYnQSEAGSHTL 2014(33);
107 RGYYnQSEAGSHTIQ 2014(33);
107 RGYYnQSEAGSHTLQW 2014(33);
107 GYYnQSEAGSHTIQWMHGCEIGPDRR 2014(16);

Sequence

1112131415161718191
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLR
101111121131141151161171181191
TLRGYYNQSEAGSHTLQWMHGCELGPDRRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETL
201211221231241251261271281291
LHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
301311321331341351
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
57Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.