| Protein | Platelet glycoprotein 4 |
| Gene | CD36 |
| Status | Reviewed |
| Source | Breast cancer xenografts; Breast cell lines; Breast tumor; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCCLM3 cell line (Liver); K562A cell line (Leukemia); K562S cell line (Leukemia); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; PBMC Macrophage cells; Pancreatic islets; Plasma; Platelet; Platelet Plasma membranes; Prostate; Prostate tumor; Serum; Urine; milk |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 79 | nSSNIQVK | 2015(1); |
| 79 | MnSSNIQVK | 2014(16); |
| 79 | MMnSSNIQVK | 2012(3); 2014(14); 2015(unpublished); |
| 79 | VMMnSSNIQVK | 2014(33); |
| 79 | DVQNPQEVMMnSSNIQ | 2014(33); |
| 79 | QNPQEVMMnSSNIQVK | 2014(14); 2015(unpublished); |
| 79 | DVQNPQEVMMnSSNIQVK | 2014(33); |
| 79 | IFDVQNPQEVMMnSSNIQ | 2014(33); |
| 79 | IFDVQNPQEVMMnSSNIQVK | 2014(33); |
| 79 | IFDVQNPQEVMMnSSNIQVKQ | 2014(33); |
| 79 | QFWIFDVQNPQEVMMnSSNIQVK | 2007(74); 2012(52); 2014(25); 2014(25); 2014(32); 2014(33); 2015(unpublished);2015(unpublished);2007;2007; |
| 79 | IFDVQNPQEVMMnSSNIQVKQRGPY | 2014(33); |
| 102 | EnVTQDAEDNTV | 2012(3); 2007(unpublished);2007(unpublished); |
| 102 | FLAKEnVTQDAE | 2014(33); |
| 102 | EnVTQDAEDNTVSF | 2014(33); |
| 102 | AKEnVTQDAEDNTVSF | 2014(33); |
| 102 | AKEnVTQDAEDNTVSFL | 2014(33); |
| 102 | LAKEnVTQDAEDNTVSF | 2014(33); |
| 102 | EnVTQDAEDNTVSFLQPN | 2014(33); |
| 102 | FLAKEnVTQDAEDNTVSF | 2014(33); |
| 134 | EPSLSVGTEADnFTVL | 2014(33); |
| 205 | nNTADGVYK | 2014(33); 2015(1); |
| 205 | YPYnNTADGVY | 2014(33); |
| 205 | FYPYnNTADGVY | 2014(33); |
| 205 | YPYnNTADGVYK | 2014(33); |
| 205 | FYPYnNTADGVYK | 2012(3); 2014(33); |
| 205 | GLFYPYnNTADGVYK | 2015(unpublished); |
| 205 | TVGLFYPYnNTADGVYK | 2014(33); |
| 205 | SLVPYPVTTTVGLFYPYnNTADGVYK | 2014(33); |
| 205 | DPFLSLVPYPVTTTVGLFYPYnNTADGVYK | 2009(64); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 205 | ELLWGYRDPFLSLVPYPVTTTVGLFYPYnNTADGVYK | 2015(unpublished); |
| 220 | VFNGKDnISK | 2012(52); 2013(34); 2014(16); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished); |
| 220 | NGKDnISKVAIIDTY | 2014(33); |
| 220 | KVFNGKDnISKVAIIDTY | 2014(33); |
| 235 | KGKRnLSYW | 2014(33); |
| 235 | nLSYWESHCDMINGTDAASFPPFVEK | 2007(74); 2015(unpublished);2015(unpublished);2007(unpublished);2007;2007; |
| 247 | nGTDAASFPPFVEK | 2015(1); |
| 247 | SHCDMInGTDAASFPPFVE | 2014(33); |
| 247 | SHCDMInGTDAASFPPFVEK | 2014(33); |
| 247 | ESHCDMInGTDAASFPPFVEK | 2014(33); |
| 247 | ESHCDMInGTDAASFPPFVEKSQVL | 2014(33); |
| 247 | NLSYWESHCDMInGTDAASFPPFVEK | 2007(74); 2015(unpublished);2015(unpublished);2007(unpublished);2007;2007; |
| 321 | IISKnCTSY | 2014(33); |
| 321 | nCTSYGVIDISK | 2014(16); |
| 321 | nCTSYGVLDISK | 2007(74); 2008(70); 2012(52); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015;2015;2007;2007; |
| 321 | CTEKIISKnCTSY | 2014(33); |
| 321 | CFCTEKIISKnCTSY | 2014(33); |
| 321 | IISKnCTSYGVLDISK | 2013(34); 2014(13); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished); |
| 417 | IVPILWLnE | 2014(33); |
| 417 | nETGTIGDEK | 2015(1); |
| 417 | YIVPILWLnE | 2014(33); |
| 417 | LnETGTIGDEK | 2009(64); 2014(14); 2014(33); 2015(unpublished); |
| 417 | NYIVPILWLnE | 2014(33); |
| 417 | RNYIVPILWLnE | 2014(33); |
| 417 | WLnETGTIGDEK | 2014(33); |
| 417 | LnETGTIGDEKAN | 2014(33); |
| 417 | LWLnETGTIGDEK | 2012(3); 2012(48); 2015(unpublished); |
| 417 | LnETGTIGDEKANMF | 2014(33); |
| 417 | WLnETGTIGDEKANMF | 2014(33); |
| 417 | IVPILWLnETGTIGDEK | 2014(33); |
| 417 | LWLnETGTIGDEKANMF | 2014(33); |
| 417 | IVPILWLnETGTIGDEKAN | 2014(33); |
| 417 | NYIVPILWLnETGTIGDEK | 2009(63); 2009(64); 2012(52); 2014(25); 2014(25); 2014(33); 2015(1); 2015(unpublished);2015(unpublished);2015;2007;2007; |
| 417 | RNYIVPIIWInETGTIGDEK | 2014(16); 2014(32); |
| 417 | RNYIVPILWLnETGTIGDEK | 2012(52); 2014(33); 2015(unpublished); |
| 417 | IVPILWLnETGTIGDEKANMF | 2014(33); |
| 417 | NYIVPILWLnETGTIGDEKANMFR | 2015(unpublished); |
| 417 | RNYIVPILWLnETGTIGDEKANMFR | 2014(33); 2015(unpublished); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MGCDRNCGLI | AGAVIGAVLA | VFGGILMPVG | DLLIQKTIKK | QVVLEEGTIA | FKNWVKTGTE | VYRQFWIFDV | QNPQEVMMNS | SNIQVKQRGP | YTYRVRFLAK |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| ENVTQDAEDN | TVSFLQPNGA | IFEPSLSVGT | EADNFTVLNL | AVAAASHIYQ | NQFVQMILNS | LINKSKSSMF | QVRTLRELLW | GYRDPFLSLV | PYPVTTTVGL |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| FYPYNNTADG | VYKVFNGKDN | ISKVAIIDTY | KGKRNLSYWE | SHCDMINGTD | AASFPPFVEK | SQVLQFFSSD | ICRSIYAVFE | SDVNLKGIPV | YRFVLPSKAF |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| ASPVENPDNY | CFCTEKIISK | NCTSYGVLDI | SKCKEGRPVY | ISLPHFLYAS | PDVSEPIDGL | NPNEEEHRTY | LDIEPITGFT | LQFAKRLQVN | LLVKPSEKIQ |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | ||
| VLKNLKRNYI | VPILWLNETG | TIGDEKANMF | RSQVTGKINL | LGLIEMILLS | VGVVMFVAFM | ISYCACRSKT | IK |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 3 | Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 25 | Sun Z, Dong J, Zhang S, Hu Z, Cheng K, Li K, Xu B, Ye M, Nie Y, Fan D, Zou H: Identification of Chemoresistance-Related Cell-Surface Glycoproteins in Leukemia Cells and Functional Validation of Candidate Glycoproteins. Journal of Proteome Research 2014, 13:1593-1601. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 63 | Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |
| 70 | Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics 2008, 8:3833-3847. |
| 74 | Lewandrowski U, Zahedi RP, Moebius J, Walter U, Sickmann A: Enhanced N-glycosylation site analysis of Sialoglycopeptides by strong cation exchange prefractionation applied to platelet plasma membranes. Molecular & Cellular Proteomics 2007, 6:1933-1941. |