Contains      

UniProtKB-P20742

Protein Pregnancy zone protein
Gene PZP
Status Reviewed
Source Bladder tumor; Liver; Lung tumor; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Plasma; Prostate tumor; Serum
Years 2005-2015

Glycosites

Site Identified Peptides Year(Publication ID)
54 GCVLLSHLnE 2014(33);
54 KGCVLLSHLnE 2014(33);
54 GCVLLSHLnETVTVSASLESGR 2015(10); 2007(unpublished);2007(unpublished);
54 KGCVLLSHLnETVTVSASLESGR 2015(unpublished);
246 KVnITVCGE 2014(33);
246 VnITVCGEYTYGKPVPGLATVSLCR 2015(unpublished);
392 ANYYSnATTNE 2014(33);
392 SnATTNEQGLAQF 2014(33);
392 LFFISVNDANYYSnATTNEQGLAQFSINTTSISVNK 2015(unpublished);
406 SInTTSISVN 2014(33);
406 SInTTSISVNK 2005( 81); 2014(33); 2007(unpublished);2007(unpublished);
406 QGLAQFSInTTSISVNK 2014(33);
406 LFFISVNDANYYSNATTNEQGLAQFSInTTSISVNK 2015(unpublished);
753 LVAVnSSGVAE 2014(33);
753 SYFPETWIWELVAVnSSGVAEVGVTVPDTITEWK 2015(unpublished);
875 TLGNVnFSVSAE 2014(33);
875 TVTPKTLGNVnF 2012(49); 2014(33);
932 TCASGAnVSEQL 2014(33);
932 TFSSMTCASGAnVSE 2014(33);
932 TFSSMTCASGAnVSEQLSLK 2005( 81); 2014(13); 2015(10); 2015(unpublished);2007(unpublished);2007;
997 VLNYLnE 2014(33);
997 VLNYLnETQQ 2009(64);
997 nETQQLTQEIK 2015(1);
997 VLNYLnETQQL 2014(33);
997 APNIYVLNYLnE 2014(33);
997 YLnETQQLTQEIK 2005( 81); 2015(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007 ;
997 VLNYLnETQQLTQEIK 2015(unpublished);
997 IYVLNYLnETQQLTQEIK 2015(unpublished);
997 VLNYLnETQQLTQEIKAKAVGY 2014(33);
1430 IYVEQVTnQTL 2014(33);
1430 TEVSNNHVLIYVEQVTnQTLSFSFMVLQDIPVGDLKPAIVK 2005(81); 2015(unpublished);

Sequence

1112131415161718191
MRKDRLLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESGRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVA
101111121131141151161171181191
FLSIQIKGPTQDFRKRNTVLVLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQG
201211221231241251261271281291
SYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQV
301311321331341351361371381391
HTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGL
401411421431441451461471481491
AQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGELSELSFHYLIMAKGV
501511521531541551561571581591
IVRSGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSV
601611621631641651661671681691
LLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGY
701711721731741751761771781791
YGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFV
801811821831841851861871881891
ELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESYCICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIK
901911921931941951961971981991
RKDTVIKTLLVEAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQ
1001101110211031104110511061107110811091
QLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGG
1101111111211131114111511161117111811191
VEDEATLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERPQRPKAPVG
1201121112211231124112511261127112811291
HLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDN
1301131113211331134113511361137113811391
NNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNRPASNMVIVDVKMVSGFIPLKP
140114111421143114411451146114711481
TVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDYYETDESVVAEYIAPCSTDTEHGNV

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
49Kim JY, Kim S-K, Kang D, Moon MH: Dual Lectin-Based Size Sorting Strategy to Enrich Targeted N-Glycopeptides by Asymmetrical Flow Field-Flow Fractionation: Profiling Lung Cancer Biomarkers. Analytical Chemistry 2012, 84:5343-5350.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
81Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Journal of Proteome Research 2005, 4:2070-2080.