Contains      

UniProtKB-P22310

Protein UDP-glucuronosyltransferase 1-4
Gene UGT1A4
Status Reviewed
Source IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; Liver; Liver tumor (HCC); Prostate; Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
119 nVSLALHR 2014(33);
119 NnVSLALHR 2014(33);
119 MNnVSLALHR 2014(33);
119 SMAIMNnVSL 2014(33);
119 AIMNnVSLALH 2014(33);
119 SMAIMNnVSLA 2014(33);
119 AIMNnVSLALHR 2014(33);
119 SMAIMNnVSLAL 2014(33);
119 SRSMAIMNnVSL 2014(33);
119 MAIMNnVSLALHR 2014(33);
119 SMAIMNnVSLALH 2014(33);
119 SRSMAIMNnVSLA 2014(33);
119 SMAIMNnVSIAIHR 2014(32); 2014(32);
119 SMAIMNnVSLALHR 2014(14); 2014(33); 2015(unpublished);
119 SRSMAIMNnVSLAL 2014(33);
119 SRSMAIMNnVSLALH 2014(33);
119 SRSMAIMNnVSLALHR 2014(33);
142 HLnATSF 2014(33);
142 HLnATSFD 2014(33);
142 HLnATSFDV 2014(33);
142 IRHLnATSF 2009(64); 2014(33);
142 HLnATSFDVV 2014(33);
142 HLnATSFDVVL 2014(33);
142 HLnATSFDVVLT 2014(33);
142 HNEALIRHLnAT 2014(33);
142 HLnATSFDVVLTD 2014(33);
142 LHNEALIRHLnAT 2014(33);
142 HNEALIRHLnATSF 2014(33);
142 HLnATSFDVVLTDPV 2014(14); 2014(33); 2015(unpublished);
142 LHNEALIRHLnATSF 2014(33);
142 HLnATSFDVVLTDPVN 2014(33);
142 LLHNEALIRHLnATSF 2014(33);
142 HLnATSFDVVLTDPVNL 2014(33);
142 HLnATSFDVVLTDPVNLC 2014(33);
142 HLnATSFDVVLTDPVNLCG 2014(33);
142 RCCVELLHNEALIRHLnATSF 2014(33);
142 HLnATSFDVVLTDPVNLCGAVL 2014(33);
142 HLnATSFDVVLTDPVNLCGAVLAK 2007(unpublished);2009(64); 2014(14); 2014(33); 2015(unpublished);
142 HLnATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWR 2014(33);
296 AYInASGE 2014(33);
296 AYInASGEH 2014(33);
296 EAYInASGEH 2014(33);
296 FEAYInASGE 2014(33);
296 InASGEHGIV 2014(33);
296 EAYInASGEHG 2014(33);
296 InASGEHGIVV 2014(33);
296 nASGEHGIVVF 2014(33);
296 EAYInASGEHGI 2014(33);
296 InASGEHGIVVF 2014(33);
296 AYInASGEHGIVV 2014(33);
296 EAYInASGEHGIV 2014(33);
296 YInASGEHGIVVF 2014(33);
296 AYInASGEHGIVVF 2014(33);
296 EAYInASGEHGIVV 2014(33);
296 SQEFEAYInASGEH 2014(33);
296 EAYInASGEHGIVVF 2009(64); 2014(33);
296 SQEFEAYInASGEHG 2014(33);
296 FEAYInASGEHGIVVF 2014(33);
296 KPLSQEFEAYInASGE 2014(33);
296 EFEAYInASGEHGIVVF 2014(33);
296 QEFEAYInASGEHGIVVF 2014(33);
296 SQEFEAYInASGEHGIVV 2014(33);
296 SQEFEAYInASGEHGIVVF 2014(33);
296 PLSQEFEAYInASGEHGIVVF 2014(33);
296 KPLSQEFEAYInASGEHGIVVF 2014(33);
296 GKPLSQEFEAYInASGEHGIVVF 2014(33);
296 InASGEHGIVVFSLGSMVSEIPEKK 2014(33);
296 AYInASGEHGIVVFSLGSMVSEIPEK 2014(33);
296 AYInASGEHGIVVFSLGSMVSEIPEKK 2014(33);
296 IGGINCANGKPLSQEFEAYInASGEHGIVVF 2014(33);
348 nNTILVK 2014(33);
348 AnNTILVK 2014(33);
348 NLAnNTIL 2014(33);
348 AnNTILVKW 2014(33);
348 LAnNTILVK 2007(75); 2014(33);
348 NLAnNTILVK 2014(33);
348 PSNLAnNTIL 2014(33);
348 NLAnNTILVKW 2014(33);
348 RPSNLAnNTIL 2014(33);
348 SNLAnNTILVK 2014(33);
348 TGTRPSNLAnN 2014(33);
348 PSNLAnNTILVK 2007(75); 2009(64); 2014(14); 2014(33); 2015(unpublished);
348 TGTRPSNLAnNT 2014(33);
348 TRPSNLAnNTIL 2014(33);
348 YTGTRPSNLAnN 2014(33);
348 GTRPSNLAnNTIL 2014(33);
348 RPSNLAnNTILVK 2014(33);
348 TGTRPSNLAnNTI 2014(33);
348 YTGTRPSNLAnNT 2014(33);
348 SNLAnNTILVKWLP 2014(33);
348 TGTRPSNLAnNTIL 2014(33);
348 TRPSNLAnNTILVK 2014(33);
348 GTRPSNLAnNTILVK 2014(33);
348 TGTRPSNLAnNTILV 2014(33);
348 YTGTRPSNLAnNTIL 2014(14); 2014(33); 2015(unpublished);
348 AnNTILVKWLPQNDLL 2014(33);
348 GTRPSNLAnNTILVKW 2014(33);
348 RYTGTRPSNLAnNTIL 2014(33);
348 TGTRPSNLAnNTILVK 2014(33);
348 YTGTRPSNLAnNTILV 2014(33);

Sequence

1112131415161718191
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGF
101111121131141151161171181191
FETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTT
201211221231241251261271281291
NSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
301311321331341351361371381391
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD
401411421431441451461471481491
NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV
501511521531
LTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
75Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149.