Contains      

UniProtKB-P24043

Protein Laminin subunit alpha-2
Gene LAMA2
Status Reviewed
Source Bladder tumor; Breast cancer xenografts; Cerebrospinal fluid; Colorectal tumor; Liver; Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate cancer metastasis to liver; Prostate stromal cell line; Prostate tumor; Serum; Urine; ovarian tumor
Years 2005-20072007

Glycosites

Site Identified Peptides Year(Publication ID)
55 ALITTnATCGEK 2012(48);
55 LASNALITTnATCGEK 2012(48);
55 NLASNALITTnATCGEK 2012(48);
55 GLFPAVLNLASNALITTnATCGEK 2014(33); 2015(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007 ;
89 ICNQnSSNPNQR 2012(48); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(10);
303 ACPLDPATnK 2014(14); 2014(22); 2015(unpublished);2015(unpublished);2015(10);
363 RnLSLNIR 2005(81); 2012(48);
470 ACnCSGLGSK 2014(22); 2014(33); 2015(10);
1597 LEQMVMSInLTGPLPAP 2012(48);
1597 LEQMVMSInLTGPLPAPYK 2009(65); 2014(14); 2007(unpublished);2007(unpublished);2007(unpublished);
1614 MLYGLEnMTQELK 2011(54); 2012(48); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2007;2007;
1700 LnETLGTR 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
1700 AIKLnETLGTR 2014(33); 2015(unpublished);2015(unpublished);
1810 nMTALEK 2014(33); 2015(unpublished);
1901 SHAAQLnDSSAVLDGILDE 2014(33);
1901 VSQAESHAAQInDSSAVIDGIIDEAK 2014(32);
1901 VSQAESHAAQLnDSSAVLDGILDEAK 2014(33); 2015(unpublished);
1901 VSQAESHAAQLnDSSAVLDGILDEAKNISFNATAAFK 2009(64); 2007(unpublished);2007(unpublished);
1916 VSQAESHAAQLNDSSAVLDGILDEAKnISFNATAAFK 2009(64); 2007(unpublished);2007(unpublished);
1920 VSQAESHAAQLNDSSAVLDGILDEAKNISFnATAAFK 2009(64); 2007(unpublished);2007(unpublished);
2017 TLnDTLGK 2014(14); 2014(22); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
2017 LRTLnDTLGKL 2009(64);
2028 LSAIPnDTAAK 2014(14); 2014(22); 2015(unpublished);2007;
2126 nLSEIK 2015(unpublished);
2126 KnISEIK 2015(unpublished);
2126 nISEIKELINQAR 2014(33);
2240 nGTISVR 2015(10);
2360 WYPnISTVMFK 2015(unpublished);
2551 InLSFSTKNE 2014(33);
2558 INLSFSTKnE 2014(33);
2558 STKnESGIILL 2014(33);
2558 nESGIILLGSGGTPAPPR 2015(unpublished);2007(unpublished);2007;
2648 YMQnITVEQPIEVK 2014(32);
2648 YMQnLTVEQPIEVK 2009(64); 2009(65); 2011(54); 2012(48); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007(UnpublishedUnpublished ); 2007;2007;2007;20072007 ;
2868 GILYVDGASnR 2014(33);
2868 QEGILYVDGASnR 2014(33); 2015(unpublished);2007;
2868 SKQEGILYVDGASnR 2014(14); 2014(33);
2893 KADILDVVGMLYVGGLPInYTTR 2007(unpublished);2007 (Unpublished );

Sequence

1112131415161718191
MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPIT
101111121131141151161171181191
NAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICT
201211221231241251261271281291
SFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDP
301311321331341351361371381391
ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRP
401411421431441451461471481491
KGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICKENVEGGDCSRC
501511521531541551561571581591
KSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGG
601611621631641651661671681691
QLTFTISYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRL
701711721731741751761771781791
SSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGT
801811821831841851861871881891
SEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL
901911921931941951961971981991
CADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGTFGLQSARGCVPCNCNSFGSKSFDCEESGQCWCQPGVTGKKCDRCA
1001101110211031104110511061107110811091
HGYFNFQEGGCTACECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHWNY
1101111111211131114111511161117111811191
PRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDE
1201121112211231124112511261127112811291
ALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLT
1301131113211331134113511361137113811391
RHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYR
1401141114211431144114511461147114811491
LRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG
1501151115211531154115511561157115811591
YEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTG
1601161116211631164116511661167116811691
PLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLN
1701171117211731174117511761177117811791
ETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREA
1801181118211831184118511861187118811891
NRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQL
1901191119211931194119511961197119811991
NDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKT
2001201120212031204120512061207120812091
RIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVK
2101211121212131214121512161217121812191
NLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMR
2201221122212231224122512261227122812291
KGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKADAVRVITFT
2301231123212331234123512361237123812391
GCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKV
2401241124212431244124512461247124812491
SYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIE
2501251125212531254125512561257125812591
ISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLS
2601261126212631264126512661267126812691
TGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPV
2701271127212731274127512761277127812791
SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESG
2801281128212831284128512861287128812891
LLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIG
2901291129212931294129512961297129812991
PVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFH
3001301130213031304130513061307130813091
VDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKP
310131113121
LEVNFAKALELRGVQPVSCPAN

Reference

ID Publication
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
65Goo YA, Lilu AY, Ryu S, Shaffer SA, Malmstrom L, Page L, Nguyen LT, Doneanu CE, Goodlett DR: Identification of Secreted Glycoproteins of Human Prostate and Bladder Stromal Cells by Comparative Quantitative Proteomics. Prostate 2009, 69:49-61.
81Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Journal of Proteome Research 2005, 4:2070-2080.