Contains      

UniProtKB-P24821

Protein Tenascin
Gene TNC
Status Reviewed
Source 22Rv1 cell line (prostate cancer); Breast Cancer cell lines; Breast cancer xenografts; Breast tumor; Colorectal tumor; DRO-1 Cell Line (Thyroid Cance); HCC cell lines (Liver); Human; LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate cancer metastasis to liver; Prostate tumor; Serum; Spermatozoa; TPC-1 Cell Line (Thyroid Cance); Urine; XTC-1 Cell Line (Thyroid Cance); milk; ovarian tumor; plasma
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
38 SGVnATLPEE 2014(33);
38 QSGVnATLPEE 2014(33);
38 KRQSGVnATIPEE 2013(37);
38 SGVnATLPEENQPVVFNHVYNIK 2014(33); 2015(unpublished);
38 QSGVnATIPEENQPVVFNHVYNIK 2013(43);
38 QSGVnATLPEENQPVVFNHVYNIK 2009(62); 2009(62); 2014(18); 2014(33); 2015(unpublished);2015;2007;
166 FCSGRGnFSTEGC 2013(37);
166 GnFSTEGCGCVCEPGWK 2013(45); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2007(Unpublished ); 2007;2007 ;
184 PGWKGPnCSEPEC 2013(37);
184 GPnCSEPECPGNCHIR 2014(32); 2014(32);
184 GPnCSEPECPGNCHLR 2007(70); 2008(3); 2012(48); 2012(40); 2013(45); 2013(45); 2013(13); 2014(22); 2014(33); 2014(10); 2015(unpublished);2015(unpublished);2015(unpublished);2007;2007;2007;
184 GPnCSEPECPGNCHLRGR 2014(22);
327 CInGTCYCEE 2014(33);
327 DRGRCInGTCYCE 2013(37);
327 CInGTCYCEEGFTGEDCGKPTCPHACHTQGR 2013(45); 2014(33); 2007(unpublished);
788 nNTRGPGLKR 2014(33);
788 ISLHIVKnNTR 2014(33);
788 HIVKnNTRGPGL 2014(33);
788 SIHIVKnNTRGPG 2013(37);
788 QTGLAPGQEYEISLHIVKnNTR 2014(18); 2014(33);
1018 FDRYRInYSIPTG 2013(37);
1018 InYSIPTGQWVGVQIPR 2013(43);
1018 LnYSLPTGQWVGVQLPR 2009(62); 2009(62); 2009(62); 2009(64); 2013(34); 2013(34); 2014(18); 2014(33); 2015(1); 2015(unpublished);2015(unpublished);2015(Unpublished ); 2015;2015;2007;2007;2007 ;
1018 YRLnYSLPTGQWVGVQLPR 2014(33);
1018 FDRYRLnYSLPTGQWVGVQLPR 2014(33);
1034 nTTSYVLR 2009(62); 2009(62); 2011(54); 2013(40); 2014(14); 2014(18); 2014(22); 2014(23); 2014(33); 2015(2); 2015(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007;
1034 VGVQLPRnTT 2014(33);
1034 VGVQLPRnTTSY 2009(64); 2014(33);
1034 GVQIPRnTTSYVI 2013(37);
1034 SLPTGQWVGVQLPRnTTSY 2014(33);
1034 GQWVGVQLPRnTTSYVLRGL 2015(6);
1034 nTTSYVLRGLEPGQEYNVLLTAEK 2014(18);
1034 nTTSYVLRGLEPGQEYNVLLTAEKGR 2014(18);
1079 ASTEQAPELEnLTVTEVGWDGLR 2008(70); 2015(unpublished);2015(unpublished);
1079 VKASTEQAPELEnLTVTEVGWDGLR 2014(18);
1093 LnWTAADQAYE 2014(33);
1093 RLnWTAADQAY 2014(33);
1093 VGWDGLRLnWT 2009(64);
1093 LnWTAADQAYEHF 2014(33);
1093 WDGIRInWTAADQ 2013(37);
1093 LnWTAADQAYEHFIIQVQEANK 2008(70); 2013(40); 2014(33); 2015(10); 2015(unpublished);2007(unpublished);2007;
1093 InWTAADQAYEHFIIQVQEANKVEAAR 2013(43);
1093 LnWTAADQAYEHFIIQVQEANKVEAAR 2014(33); 2015(unpublished);
1119 nLTVPGSLR 2008(70); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(10);
1119 KVEAARnITVPGS 2013(37);
1119 IIQVQEANKVEAARnL 2014(33);
1119 IIQVQEANKVEAARnLTVPGSL 2014(33);
1184 LnWTAPE 2014(33);
1184 KLnWTAPEGAY 2014(33);
1184 LnWTAPEGAYEY 2014(33);
1184 KLnWTAPEGAYEY 2014(33);
1184 LnWTAPEGAYEYF 2014(33);
1184 KLnWTAPEGAYEYF 2014(33);
1184 LKLnWTAPEGAYEY 2009(64);
1210 nLTVPGGLR 2015(1);
1210 AAQnLTVPGGLR 2014(33);
1210 EAAQnLTVPGGLR 2007(unpublished);2007(unpublished);2007(unpublished);
1210 ADTVEAAQnLTVPGGLR 2014(33);
1210 EADTVEAAQnLTVPGGLR 2015(unpublished);
1210 FIQVQEADTVEAAQnLTVPGGLR 2014(33);
1261 MGnLTVTEVSWDALR 2008(70);
1261 VLTEEVPDMGnLTVTE 2014(33);
1261 TEEVPDMGnLTVTEVSWDALR 2007(unpublished);
1275 LnWTTPDGTYDQF 2014(33);
1275 RLnWTTPDGTYDQF 2014(33);
1275 ALRLnWTTPDGTYDQ 2009(64);
1275 DALRLnWTTPDGTYDQF 2014(33);
1275 TEVSWDALRLnWTTPDGTYD 2015(6);
1275 LnWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLR 2009(64); 2015(unpublished);
1301 nLTVPGSLR 2008(70); 2014(14); 2014(22); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(10);
1301 AHnLTVPGSLR 2014(33);
1301 TIQVQEADQVEEAHnL 2014(33);
1301 EADQVEEAHnLTVPGSLR 2015(unpublished);
1301 VQEADQVEEAHnLTVPGSLR 2015(unpublished);
1301 TIQVQEADQVEEAHnLTVPGSLR 2014(33); 2015(unpublished);
1301 LNWTTPDGTYDQFTIQVQEADQVEEAHnLTVPGSLR 2009(64); 2015(unpublished);
1366 LnWTAADNAYE 2014(33);
1366 RLnWTAADNAY 2014(33);
1366 VGWDGLRLnWT 2009(64);
1366 LnWTAADNAYEHF 2014(33);
1366 RLnWTAADNAYEHF 2014(33);
1366 LnWTAADNAYEHFVIQVQEVNK 2014(33); 2015(unpublished);2015(10);
1392 KVEAAQnL 2014(33);
1392 nLTLPGSLR 2015(1);
1392 AAQnLTLPGSLR 2014(33);
1392 KVEAAQnITIPGS 2013(37);
1392 VEAAQnITIPGSIR 2013(43); 2014(32); 2014(32);
1392 VEAAQnLTLPGSLR 2009(62); 2009(62); 2011(54); 2012(3); 2012(48); 2013(34); 2013(40); 2014(14); 2014(22); 2014(33); 2015(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007;
1392 KVEAAQnLTLPGSLR 2015(unpublished);
1392 VNKVEAAQnLTLPGSLR 2014(33);
1445 IGNLnVSDITPE 2014(33);
1445 EPEIGNLnVSDITPESF 2014(33);
1445 RTPVLSAEASTAKEPEIGNLnVSDITPESF 2014(33);
1455 SFnLSWMATDGIFE 2014(33);
1485 YnISGAER 2014(33);
1485 TVEYnISGAER 2014(33);
1485 IETVEYnISGAER 2013(37);
1485 IIETVEYnISGAER 2013(43); 2014(32); 2014(32);
1485 LLETVEYnISGAER 2008(70); 2009(62); 2009(62); 2009(62); 2009(64); 2012(48); 2012(50); 2013(34); 2013(40); 2013(45); 2014(14); 2014(18); 2014(22); 2014(33); 2015(2); 2015(10); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
1809 nITDSEALAR 2015(1);

Sequence

1112131415161718191
MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVF
101111121131141151161171181191
THRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRC
201211221231241251261271281291
IDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECV
301311321331341351361371381391
CDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTG
401411421431441451461471481491
ADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQ
501511521531541551561571581591
CPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNN
601611621631641651661671681691
LGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKK
701711721731741751761771781791
SIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTT
801811821831841851861871881891
TRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLR
901911921931941951961971981991
RVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS
1001101110211031104110511061107110811091
LTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQA
1101111111211131114111511161117111811191
YEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQ
1201121112211231124112511261127112811291
EADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAH
1301131113211331134113511361137113811391
NLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLR
1401141114211431144114511461147114811491
AVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPP
1501151115211531154115511561157115811591
STDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVS
1601161116211631164116511661167116811691
GFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQ
1701171117211731174117511761177117811791
TVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALD
1801181118211831184118511861187118811891
GPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQS
1901191119211931194119511961197119811991
ETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTI
2001201120212031204120512061207120812091
YLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYK
2101211121212131214121512161217121812191
LKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKR
2201
A

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
3Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11.
6Kim DS, Hahn Y: The acquisition of novel N-glycosylation sites in conserved proteins during human evolution. Bmc Bioinformatics 2015, 16.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
23Pan C, Zhou Y, Dator R, Ginghina C, Zhao Y, Movius J, Peskind E, Zabetian CP, Quinn J, Galasko D, et al: Targeted Discovery and Validation of Plasma Biomarkers of Parkinson's Disease. Journal of Proteome Research 2014, 13:4535-4545.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
43Wang GG, Wu YB, Zhou T, Guo YS, Zheng B, Wang J, Bi Y, Liu FJ, Zhou ZM, Guo XJ, Sha JH: Mapping of the N-Linked Glycoproteome of Human Spermatozoa. Journal of Proteome Research 2013, 12:5750-5759.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
50Whitmore TE, Peterson A, Holzman T, Eastham A, Amon L, McIntosh M, Ozinsky A, Nelson PS, Martin DB: Integrative Analysis of N-Linked Human Glycoproteomic Data Sets Reveals PTPRF Ectodomain as a Novel Plasma Biomarker Candidate for Prostate Cancer. Journal of Proteome Research 2012, 11:2653-2665.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
62Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
70Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics 2008, 8:3833-3847.