Contains      

UniProtKB-P25391

Protein Laminin subunit alpha-1
Gene LAMA1
Status Reviewed
Source Breast Cancer cell lines; Breast cancer xenografts; HEK293T cell line (embryonic kidney); Hela cell line (cervical cancer); Liver; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Urine
Years 2009-2015

Glycosites

Site Identified Peptides Year(Publication ID)
38 ISTnATCGEK 2015(unpublished);
555 HQVSInNTAVMQR 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);
555 RHQVSInNTAVMQ 2013(37);
665 DQLMTVLAnVTHLLIR 2015(unpublished);
665 QIDRDQLMTVLAnVTHLLIR 2015(unpublished);
763 nTTGVHCEQCLPGFYGEPSR 2015(1);
1045 nCSLVGSTHHR 2015(1);
1407 nHSDTCDPNTGK 2015(1);
1596 SNLEnTTK 2015(unpublished);
1596 GILSNLEnTTK 2011(57); 2015(unpublished);
1717 DFTQLHQnATLELK 2015(unpublished);2015(1); 2015(unpublished);
1804 nLTSELIVQGR 2015(1);
1804 LHVQEEQnLTSELIVQGR 2015(1); 2015(unpublished);
1991 EITRQTnESIIII 2013(37);
2038 nTSASLSR 2015(1);
2038 DVAGLSQELLnTSASLSR 2011(57); 2015(unpublished);2015(1); 2015(unpublished);2015(12);
2038 DVAGLSQELLnTSASLSRVNTTLR 2011(57);
2047 DVAGLSQELLNTSASLSRVnTTLR 2011(57);
2098 nLSEIK 2015(unpublished);
2243 SPGTANVLDVnNSTLMFVGGLGGQIK 2015(unpublished);2015(1);
2243 SPGTANVLDVnNSTLMFVGGLGGQIKK 2009(64);
2244 nSTLMFVGGLGGQIK 2015(1);
2244 SPGTANVLDVNnSTLMFVGGLGGQIK 2015(unpublished);2015(1);
2244 SPGTANVLDVNnSTLMFVGGLGGQIKK 2009(64);
2384 YNnGTWYK 2015(unpublished);
2384 TDRRYNnGTWYKI 2013(37);
2408 QGVLAVIDAYnTSNK 2015(unpublished);
2619 TInVSNLYVGGIPEGEGTSLLTMR 2015(unpublished);2015(1); 2015(unpublished);
2729 SHFILPFnQSAVR 2015(unpublished);
2852 QARKIGnITHSIP 2013(37);
2852 IGnITHSIPACIGDVTVNSK 2015(unpublished);
2915 VQSDVnITLEFR 2015(1);

Sequence

1112131415161718191
MRGGVLLVLLLCVAAQCRQRGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPVRNPQCRICDGNSANPRERHPISHAIDGTNNWWQSPSIQN
101111121131141151161171181191
GREYHWVTITLDLRQVFQVAYVIIKAANAPRPGNWILERSLDGTTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTSYYSRLVPLEHGEIHTS
201211221231241251261271281291
LINGRPSADDLSPKLLEFTSARYIRLRLQRIRTLNADLMTLSHREPKELDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDETTKKLQCQCEHNTCGES
301311321331341351361371381391
CNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCD
401411421431441451461471481491
PVGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPTCVSCGCNPVGSASDEPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGC
501511521531541551561571581591
SECFCFGVSDVCSSLSWPVGQVNSMSGWLVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETV
601611621631641651661671681691
DSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDL
701711721731741751761771781791
VVAADVEHCECPQGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASN
801811821831841851861871881891
NFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCR
901911921931941951961971981991
ACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCDC
1001101110211031104110511061107110811091
PHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCVPCDCDLRGTSGD
1101111111211131114111511161117111811191
ACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQPLLRVVSQSNLRGTTEGVYYQAPD
1201121112211231124112511261127112811291
FLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYSVAFYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSV
1301131113211331134113511361137113811391
SEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPC
1401141114211431144114511461147114811491
VPCSCNNHSDTCDPNTGKCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQ
1501151115211531154115511561157115811591
TPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDECEPRHILMETDCVSCDDECVGVLLNDLDEIGDAVLSLNLTGIIPVPYGILSNLENTTKY
1601161116211631164116511661167116811691
LQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKTTLNQTLDEDFLLPNSTLQNMQQNGT
1701171117211731174117511761177117811791
SLLEIMQIRDFTQLHQNATLELKAAEDLLSQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQ
1801181118211831184118511861187118811891
EEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRNVSLNAT
1901191119211931194119511961197119811991
SAAYVHYNIQSLIEESEELARDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGNNLSRKLPGIALELSELRNKTNRFQENAVEITRQTNESLLILRAI
2001201120212031204120512061207120812091
PKGIRDKGAKTKELATSASQSAVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDVEIQANLLFDRLKPLKMLEENLSRNLS
2101211121212131214121512161217121812191
EIKLLISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNR
2201221122212231224122512261227122812291
WHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFGS
2301231123212331234123512361237123812391
SQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGV
2401241124212431244124512461247124812491
LAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYGVRKGCLLEPIRSVSFLKGGYIELP
2501251125212531254125512561257125812591
PKSLSPESEWLVTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQLD
2601261126212631264126512661267126812691
ENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQ
2701271127212731274127512761277127812791
CVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTV
2801281128212831284128512861287128812891
KTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCYAVAQEGTYFDGSGY
2901291129212931294129512961297129812991
AALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGA
30013011302130313041305130613071
ESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFDFSRAFELHGVFLHSCPGTES

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
57Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.