| Protein | Integrin alpha-3 |
| Gene | ITGA3 |
| Status | Reviewed |
| Source | ARO Cell Line (Thyroid Cance); Breast Cancer cell lines; Breast cancer cell lines; Breast cancer xenografts; Breast cancer xenograftsPBMC Macrophage cells; Breast cell lines; Breast tumor; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); FTC-133 Cell Line (Thyroid Cance); HCC cell lines (Liver); HCC cell lines (Liver)Jurkat T cell line; HCCLM3 cell line (Liver); HEK293 cell line (embryonic kidney); HeLa cell line (Cervical cancer); Hela cell line (cervical cancer); IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; LNCap/PC3 cell lines (Prostate cancer); Liver; Lymphocytes; Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Ovarian cancer cell lines; Ovarian tumor; Ovarian tumorJurkat T cell line; Pancreatic islets; Prostate; Prostate tumor; SKOV-3 cell line (Ovarian cancer); SW1990 cell line (Pancreatic cancer); Serum; TPC-1 Cell Line (Thyroid Cance); Urine; XTC-1 Cell Line (Thyroid Cance); ovarian tumor; prostate cancer cell lines |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 86 | LAVPDGYTnR | 2014(33); |
| 86 | EIAVPDGYTnR | 2014(16); |
| 86 | ELAVPDGYTnR | 2007(72); 2007(75); 2009(62); 2011(54); 2012(47); 2012(48); 2012(52); 2013(34); 2013(34); 2013(40); 2014(13); 2014(14); 2014(18); 2014(22); 2014(33); 2015(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007; |
| 86 | VPDGYTnRTGAVY | 2013(37); |
| 86 | AVPDGYTnRTGAVY | 2014(33); |
| 107 | MnITVK | 2012(47); 2014(22); 2014(33); 2015(2); 2015(unpublished);2015(12); |
| 107 | DDCERMnITVK | 2007(72); 2013(34); |
| 107 | TGAVYICPITAHKDDCERMnITVK | 2014(16); |
| 107 | TGAVYLCPLTAHKDDCERMnITVK | 2011(58); 2013(34); 2013(34); |
| 265 | nITIVTGAPR | 2007(72); 2007(75); 2007(62); 2009(62); 2009(62); 2009(62); 2009(63); 2009(67); 2009(54); 2011(58); 2011(47); 2012(52); 2012(34); 2013(40); 2013(13); 2014(14); 2014(15); 2014(16); 2014(17); 2014(18); 2014(22); 2014(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;2007; |
| 265 | FIIHPKnITIVTG | 2013(37); |
| 500 | nQSAGNPNYR | 2015(1); |
| 500 | YnQSAGNPNYR | 2007(unpublished);2007(unpublished); |
| 500 | AYnQSAGNPNYR | 2014(33); |
| 500 | FAYnQSAGNPNYR | 2015(unpublished); |
| 500 | LCFAYnQSAGNPNYR | 2012(48); 2014(33); |
| 500 | PAVLDPALCTATSCVQVELCFAYnQSAGNPNYR | 2015(unpublished); |
| 511 | nITLAYTLEADR | 2007(72); 2012(52); 2015(unpublished);2015(unpublished); |
| 511 | RnITLAYTLEADR | 2012(52); 2015(unpublished);2015(1); 2015(unpublished); |
| 511 | nITLAYTLEADRDR | 2012(52); 2013(34); 2013(34); 2015(unpublished);2015(1); 2015(2); 2015(unpublished); |
| 511 | RnITLAYTLEADRDR | 2007(75); 2007(58); 2011(48); 2012(52); 2012(34); 2013(1); 2015(2); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 511 | nITLAYTLEADRDRRPPR | 2015(2); |
| 573 | nYSLPLR | 2015(1); |
| 573 | RPIIISMnY | 2014(33); |
| 573 | LRPIIISMnY | 2012(48); 2014(33); |
| 573 | PIIISMnYSIPIR | 2013(37); |
| 573 | LRPIIISMnYSLPL | 2012(48); |
| 573 | LRPIIISMnYSLPLR | 2007(62); 2009(58); 2011(48); 2012(52); 2012(34); 2013(34); 2013(13); 2014(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007(unpublished);2007;2007;2007; |
| 573 | DKLRPIIISMnYSLPLR | 2009(62); 2011(58); 2012(52); 2013(34); 2013(34); 2015(1); 2015(2); |
| 573 | LRPIIISMnYSLPLRMPDRPR | 2011(58); |
| 573 | DKLRPIIISMnYSLPLRMPDRPR | 2011(58); |
| 605 | nHTEVQFQK | 2015(1); |
| 605 | EnHTEVQFQK | 2015(unpublished); |
| 605 | ALEnHTEVQFQK | 2007(unpublished);2015(unpublished); |
| 605 | QAQAIEnHTEVQF | 2013(37); |
| 605 | QAQALEnHTEVQFQK | 2015(unpublished); |
| 605 | LNQAQALEnHTEVQFQK | 2012(48); |
| 605 | PILNQAQALEnHTEVQFQK | 2012(52); |
| 605 | SLDAYPILNQAQALEnHTE | 2014(33); |
| 605 | SIDAYPIINQAQAIEnHTEVQFQK | 2014(16); 2014(32); |
| 605 | SLDAYPILNQAQALEnHTEVQFQK | 2009(62); 2009(62); 2009(62); 2011(58); 2012(52); 2013(34); 2013(34); 2013(40); 2014(15); 2014(18); 2014(33); 2015(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2007(unpublished);2007;2007; |
| 605 | SLDAYPILNQAQALEnHTEVQFQKECGPDNK | 2013(34); 2015(12); |
| 605 | SLDAYPILNQAQALEnHTEVQFQKECGPDNKCESNLQMR | 2015(12); |
| 656 | SInVTNTR | 2014(33); |
| 656 | LLLSInVTNTR | 2007(75); 2007(62); 2009(58); 2011(52); 2012(34); 2013(33); 2014(1); 2015(2); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;2007; |
| 656 | KLLLSInVTNTR | 2011(58); 2012(52); 2014(33); 2015(unpublished);2015(1); 2015(2); 2015(12); |
| 656 | KIIISInVTNTRT | 2013(37); |
| 697 | SSVRPPGACQAnETIF | 2014(33); |
| 697 | SSVRPPGACQAnETIFCELGNPF | 2014(33); |
| 697 | SVRPPGACQAnETIFCELGNPFK | 2015(unpublished); |
| 697 | SSVRPPGACQAnETIFCELGNPFK | 2015(unpublished); |
| 697 | LSSVRPPGACQAnETIFCELGNPFK | 2012(48); |
| 697 | SGEDAHEALLTLVVPPALLLSSVRPPGACQAnETIFCELGNPFK | 2011(58); |
| 697 | SGEDAHEALLTLVVPPALLLSSVRPPGACQAnETIFCELGNPFKR | 2011(58); 2012(52); |
| 841 | nGSWPCRPPGDLINPL | 2015(1); |
| 841 | WLLYPTEITVHGnGSWPCRPPGDLINPLNLTLSDPGDRPSSPQR | 2015(1); |
| 857 | WLLYPTEITVHGNGSWPCRPPGDLINPLnLTLSDPGDRPSSPQR | 2015(1); |
| 926 | DAPVVTnVTVKAR | 2013(37); |
| 926 | LECPIPDAPVVTnVTVK | 2012(48); 2014(33); |
| 926 | AHCVWIECPIPDAPVVTnVTVK | 2014(16); |
| 926 | AHCVWLECPIPDAPVVTnVTVK | 2007(75); 2009(62); 2011(58); 2012(48); 2012(52); 2013(34); 2014(15); 2014(17); 2014(33); 2015(unpublished);2015(1); 2015(12); |
| 935 | nSTFIEDYRDF | 2014(33); |
| 935 | VWnSTFIEDYR | 2007(75); 2007(62); 2009(62); 2009(63); 2009(58); 2011(48); 2012(52); 2012(34); 2013(34); 2013(40); 2013(13); 2014(18); 2014(22); 2014(33); 2014(1); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;2007; |
| 935 | RVWnSTFIEDYR | 2015(unpublished); |
| 935 | ARVWnSTFIEDYR | 2015(12); |
| 935 | nSTFIEDYRDFDR | 2012(48); |
| 935 | VKARVWnSTFIED | 2013(37); |
| 935 | VWnSTFIEDYRDFDR | 2007(75); 2011(58); 2012(48); 2012(52); 2013(34); 2013(34); 2014(33); 2015(unpublished);2015(1); 2015(2); 2015(12); |
| 935 | VWnSTFIEDYRDFDRVR | 2011(58); 2014(16); 2015(1); 2015(2); |
| 969 | TSIPTINMEnK | 2007(72); 2009(62); 2012(47); 2012(48); 2012(52); 2013(34); 2013(40); 2014(13); 2014(14); 2014(16); 2014(18); 2014(22); 2014(33); 2015(2); 2015(unpublished);2015(unpublished);2007;2007; |
| 969 | PTINMEnKTTWFS | 2013(37); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MGPGPSRAPR | APRLMLCALA | LMVAAGGCVV | SAFNLDTRFL | VVKEAGNPGS | LFGYSVALHR | QTERQQRYLL | LAGAPRELAV | PDGYTNRTGA | VYLCPLTAHK |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| DDCERMNITV | KNDPGHHIIE | DMWLGVTVAS | QGPAGRVLVC | AHRYTQVLWS | GSEDQRRMVG | KCYVRGNDLE | LDSSDDWQTY | HNEMCNSNTD | YLETGMCQLG |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| TSGGFTQNTV | YFGAPGAYNW | KGNSYMIQRK | EWDLSEYSYK | DPEDQGNLYI | GYTMQVGSFI | LHPKNITIVT | GAPRHRHMGA | VFLLSQEAGG | DLRRRQVLEG |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| SQVGAYFGSA | IALADLNNDG | WQDLLVGAPY | YFERKEEVGG | AIYVFMNQAG | TSFPAHPSLL | LHGPSGSAFG | LSVASIGDIN | QDGFQDIAVG | APFEGLGKVY |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| IYHSSSKGLL | RQPQQVIHGE | KLGLPGLATF | GYSLSGQMDV | DENFYPDLLV | GSLSDHIVLL | RARPVINIVH | KTLVPRPAVL | DPALCTATSC | VQVELCFAYN |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| QSAGNPNYRR | NITLAYTLEA | DRDRRPPRLR | FAGSESAVFH | GFFSMPEMRC | QKLELLLMDN | LRDKLRPIII | SMNYSLPLRM | PDRPRLGLRS | LDAYPILNQA |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| QALENHTEVQ | FQKECGPDNK | CESNLQMRAA | FVSEQQQKLS | RLQYSRDVRK | LLLSINVTNT | RTSERSGEDA | HEALLTLVVP | PALLLSSVRP | PGACQANETI |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| FCELGNPFKR | NQRMELLIAF | EVIGVTLHTR | DLQVQLQLST | SSHQDNLWPM | ILTLLVDYTL | QTSLSMVNHR | LQSFFGGTVM | GESGMKTVED | VGSPLKYEFQ |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| VGPMGEGLVG | LGTLVLGLEW | PYEVSNGKWL | LYPTEITVHG | NGSWPCRPPG | DLINPLNLTL | SDPGDRPSSP | QRRRRQLDPG | GGQGPPPVTL | AAAKKAKSET |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| VLTCATGRAH | CVWLECPIPD | APVVTNVTVK | ARVWNSTFIE | DYRDFDRVRV | NGWATLFLRT | SIPTINMENK | TTWFSVDIDS | ELVEELPAEI | ELWLVLVAVG |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | ||||
| AGLLLLGLII | LLLWKCGFFK | RARTRALYEA | KRQKAEMKSQ | PSETERLTDD | Y |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 15 | Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 17 | Fang C, Xiong Z, Qin H, Huang G, Liu J, Ye M, Feng S, Zou H: One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. Analytica Chimica Acta 2014, 841:99-105. |
| 18 | Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 47 | Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S-H, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics 2012, 11:M112. 017558. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 54 | Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687. |
| 58 | Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993. |
| 62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |
| 63 | Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672. |
| 67 | McDonald CA, Yang JY, Marathe V, Yen T-Y, Macher BA: Combining Results from Lectin Affinity Chromatography and Glycocapture Approaches Substantially Improves the Coverage of the Glycoproteome. Molecular & Cellular Proteomics 2009, 8:287-301. |
| 72 | Hanson SR, Hsu T-L, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong C-H: Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society 2007, 129:7266-+. |
| 75 | Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149. |