Detail

UniProtKB-P29144


Protein	Tripeptidyl-peptidase 2
Gene	TPP2
Status	Reviewed
Source	HCC cell lines (Liver); Liver; OVCAR-3 cell line (Ovarian cancer)
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
161	nGSSQANK	2015(1);
161	FDVANnGSSQANK	2014(33);
161	QEEFDVANnGSSQA	2007(unpublished);
161	KQEEFDVANnGSSQANK	2013(40); 2014(33);
925	nHSFALLGK	2015(1);

Sequence

1	11	21	31	41	51	61	71	81	91
MATAATEEPF	PFHGLLPKKE	TGAASFLCRY	PEYDGRGVLI	AVLDTGVDPG	APGMQVTTDG	KPKIVDIIDT	TGSGDVNTAT	EVEPKDGEIV	GLSGRVLKIP
101	111	121	131	141	151	161	171	181	191
ASWTNPSGKY	HIGIKNGYDF	YPKALKERIQ	KERKEKIWDP	VHRVALAEAC	RKQEEFDVAN	NGSSQANKLI	KEELQSQVEL	LNSFEKKYSD	PGPVYDCLVW
201	211	221	231	241	251	261	271	281	291
HDGEVWRACI	DSNEDGDLSK	STVLRNYKEA	QEYGSFGTAE	MLNYSVNIYD	DGNLLSIVTS	GGAHGTHVAS	IAAGHFPEEP	ERNGVAPGAQ	ILSIKIGDTR
301	311	321	331	341	351	361	371	381	391
LSTMETGTGL	IRAMIEVINH	KCDLVNYSYG	EATHWPNSGR	ICEVINEAVW	KHNIIYVSSA	GNNGPCLSTV	GCPGGTTSSV	IGVGAYVSPD	MMVAEYSLRE
401	411	421	431	441	451	461	471	481	491
KLPANQYTWS	SRGPSADGAL	GVSISAPGGA	IASVPNWTLR	GTQLMNGTSM	SSPNACGGIA	LILSGLKANN	IDYTVHSVRR	ALENTAVKAD	NIEVFAQGHG
501	511	521	531	541	551	561	571	581	591
IIQVDKAYDY	LVQNTSFANK	LGFTVTVGNN	RGIYLRDPVQ	VAAPSDHGVG	IEPVFPENTE	NSEKISLQLH	LALTSNSSWV	QCPSHLELMN	QCRHINIRVD
601	611	621	631	641	651	661	671	681	691
PRGLREGLHY	TEVCGYDIAS	PNAGPLFRVP	ITAVIAAKVN	ESSHYDLAFT	DVHFKPGQIR	RHFIEVPEGA	TWAEVTVCSC	SSEVSAKFVL	HAVQLVKQRA
701	711	721	731	741	751	761	771	781	791
YRSHEFYKFC	SLPEKGTLTE	AFPVLGGKAI	EFCIARWWAS	LSDVNIDYTI	SFHGIVCTAP	QLNIHASEGI	NRFDVQSSLK	YEDLAPCITL	KNWVQTLRPV
801	811	821	831	841	851	861	871	881	891
SAKTKPLGSR	DVLPNNRQLY	EMVLTYNFHQ	PKSGEVTPSC	PLLCELLYES	EFDSQLWIIF	DQNKRQMGSG	DAYPHQYSLK	LEKGDYTIRL	QIRHEQISDL
901	911	921	931	941	951	961	971	981	991
ERLKDLPFIV	SHRLSNTLSL	DIHENHSFAL	LGKKKSSNLT	LPPKYNQPFF	VTSLPDDKIP	KGAGPGCYLA	GSLTLSKTEL	GKKADVIPVH	YYLIPPPTKT
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
KNGSKDKEKD	SEKEKDLKEE	FTEALRDLKI	QWMTKLDSSD	IYNELKETYP	NYLPLYVARL	HQLDAEKERM	KRLNEIVDAA	NAVISHIDQT	ALAVYIAMKT
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
DPRPDAATIK	NDMDKQKSTL	VDALCRKGCA	LADHLLHTQA	QDGAISTDAE	GKEEEGESPL	DSLAETFWET	TKWTDLFDNK	VLTFAYKHAL	VNKMYGRGLK
1201	1211	1221	1231	1241
FATKLVEEKP	TKENWKNCIQ	LMKLLGWTHC	ASFTENWLPI	MYPPDYCVF

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.