Contains      

UniProtKB-P30510

Protein HLA class I histocompatibility antigen, Cw-14 alpha chain
Gene HLA-C
Status Reviewed
Source Breast Cancer cell lines; DLBCL cell lines (Diffuse large B-cell lymphoma); HEK293T cell line (embryonic kidney); Liver; Liver tumor (HCC); Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; ovarian tumor
Years 2009-2015

Glycosites

Site Identified Peptides Year(Publication ID)
110 YYnQSE 2014(33);
110 GYYnQSE 2014(33);
110 LRGYYnQSE 2009(64);
110 nQSEAGSHTI 2014(33);
110 nQSEAGSHTL 2014(33);
110 GYYnQSEAGSH 2011(54); 2011(57); 2014(33);
110 nQSEAGSHTLQ 2014(33);
110 YYnQSEAGSHT 2014(14);
110 nQSEAGSHTLQW 2014(33);
110 RGYYnQSEAGSH 2014(33);
110 GYYnQSEAGSHTI 2012(48); 2014(14); 2014(33); 2015(unpublished);
110 GYYnQSEAGSHTL 2014(33); 2015(unpublished);
110 NIRGYYnQSEAGS 2013(37);
110 GYYnQSEAGSHTIQ 2012(48);
110 GYYnQSEAGSHTLQ 2011(57); 2014(33);
110 LRGYYnQSEAGSHT 2009(64);
110 RGYYnQSEAGSHTI 2014(33);
110 RGYYnQSEAGSHTL 2014(33);
110 RGYYnQSEAGSHTIQ 2014(33);
110 RNLRGYYnQSEAGSH 2014(33);
110 RGYYnQSEAGSHTLQW 2014(33);
110 GYYnQSEAGSHTIQWMFGCDIGPDGR 2014(16); 2014(32); 2014(32);
110 GYYnQSEAGSHTLQWMFGCDLGPDGR 2014(33);

Sequence

1112131415161718191
MRVMAPRTLILLLSGALALTETWACSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRV
101111121131141151161171181191
SLRNLRGYYNQSEAGSHTLQWMFGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGK
201211221231241251261271281291
ETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEP
301311321331341351361
SSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
16Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
57Chen Y, Cao J, Yan G, Lu H, Yang P: Two-step protease digestion and glycopeptide capture approach for accurate glycosite identification and glycoprotein sequence coverage improvement. Talanta 2011, 85:70-75.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.