Detail

UniProtKB-P33527


Protein	Multidrug resistance-associated protein 1
Gene	ABCC1
Status	Reviewed
Source	Breast cancer xenografts; HCC cell lines (Liver); HEK293 cell line (embryonic kidney); Lymphocytes; OVCAR-3 cell line (Ovarian cancer); Prostate tumor
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
23	nTSNPDFTK	2015(1);
354	FVnDTK	2013(40); 2014(15); 2015(unpublished);
1006	TDDPIVnGTQEHTK	2007(unpublished);2007(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MALRGFCSAD	GSDPLWDWNV	TWNTSNPDFT	KCFQNTVLVW	VPCFYLWACF	PFYFLYLSRH	DRGYIQMTPL	NKTKTALGFL	LWIVCWADLF	YSFWERSRGI
101	111	121	131	141	151	161	171	181	191
FLAPVFLVSP	TLLGITMLLA	TFLIQLERRK	GVQSSGIMLT	FWLVALVCAL	AILRSKIMTA	LKEDAQVDLF	RDITFYVYFS	LLLIQLVLSC	FSDRSPLFSE
201	211	221	231	241	251	261	271	281	291
TIHDPNPCPE	SSASFLSRIT	FWWITGLIVR	GYRQPLEGSD	LWSLNKEDTS	EQVVPVLVKN	WKKECAKTRK	QPVKVVYSSK	DPAQPKESSK	VDANEEVEAL
301	311	321	331	341	351	361	371	381	391
IVKSPQKEWN	PSLFKVLYKT	FGPYFLMSFF	FKAIHDLMMF	SGPQILKLLI	KFVNDTKAPD	WQGYFYTVLL	FVTACLQTLV	LHQYFHICFV	SGMRIKTAVI
401	411	421	431	441	451	461	471	481	491
GAVYRKALVI	TNSARKSSTV	GEIVNLMSVD	AQRFMDLATY	INMIWSAPLQ	VILALYLLWL	NLGPSVLAGV	AVMVLMVPVN	AVMAMKTKTY	QVAHMKSKDN
501	511	521	531	541	551	561	571	581	591
RIKLMNEILN	GIKVLKLYAW	ELAFKDKVLA	IRQEELKVLK	KSAYLSAVGT	FTWVCTPFLV	ALCTFAVYVT	IDENNILDAQ	TAFVSLALFN	ILRFPLNILP
601	611	621	631	641	651	661	671	681	691
MVISSIVQAS	VSLKRLRIFL	SHEELEPDSI	ERRPVKDGGG	TNSITVRNAT	FTWARSDPPT	LNGITFSIPE	GALVAVVGQV	GCGKSSLLSA	LLAEMDKVEG
701	711	721	731	741	751	761	771	781	791
HVAIKGSVAY	VPQQAWIQND	SLRENILFGC	QLEEPYYRSV	IQACALLPDL	EILPSGDRTE	IGEKGVNLSG	GQKQRVSLAR	AVYSNADIYL	FDDPLSAVDA
801	811	821	831	841	851	861	871	881	891
HVGKHIFENV	IGPKGMLKNK	TRILVTHSMS	YLPQVDVIIV	MSGGKISEMG	SYQELLARDG	AFAEFLRTYA	STEQEQDAEE	NGVTGVSGPG	KEAKQMENGM
901	911	921	931	941	951	961	971	981	991
LVTDSAGKQL	QRQLSSSSSY	SGDISRHHNS	TAELQKAEAK	KEETWKLMEA	DKAQTGQVKL	SVYWDYMKAI	GLFISFLSIF	LFMCNHVSAL	ASNYWLSLWT
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
DDPIVNGTQE	HTKVRLSVYG	ALGISQGIAV	FGYSMAVSIG	GILASRCLHV	DLLHSILRSP	MSFFERTPSG	NLVNRFSKEL	DTVDSMIPEV	IKMFMGSLFN
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
VIGACIVILL	ATPIAAIIIP	PLGLIYFFVQ	RFYVASSRQL	KRLESVSRSP	VYSHFNETLL	GVSVIRAFEE	QERFIHQSDL	KVDENQKAYY	PSIVANRWLA
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
VRLECVGNCI	VLFAALFAVI	SRHSLSAGLV	GLSVSYSLQV	TTYLNWLVRM	SSEMETNIVA	VERLKEYSET	EKEAPWQIQE	TAPPSSWPQV	GRVEFRNYCL
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
RYREDLDFVL	RHINVTINGG	EKVGIVGRTG	AGKSSLTLGL	FRINESAEGE	IIIDGINIAK	IGLHDLRFKI	TIIPQDPVLF	SGSLRMNLDP	FSQYSDEEVW
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
TSLELAHLKD	FVSALPDKLD	HECAEGGENL	SVGQRQLVCL	ARALLRKTKI	LVLDEATAAV	DLETDDLIQS	TIRTQFEDCT	VLTIAHRLNT	IMDYTRVIVL
1501	1511	1521	1531
DKGEIQEYGA	PSDLLQQRGL	FYSMAKDAGL	V

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
15	Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.