Contains      

UniProtKB-P35555

Protein Fibrillin-1
Gene FBN1
Status Reviewed
Source Bladder stromal cell line; Bladder tumor; Breast Cancer cell lines; Breast cancer xenografts; Breast tumor; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; HCC cell lines (Liver); HCC cell lines (Liver)Jurkat T cell line; Hela cell line (cervical cancer); HuH-7 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Prostate; Prostate cancer metastasis to liver; Prostate stromal cell line; Prostate tumor; SKOV-3 cell line (Ovarian cancer); Serum; TPC-1 Cell Line (Thyroid Cance); Urine; XTC-1 Cell Line (Thyroid Cance); ovarian tumor
Years 2007-20072007

Glycosites

Site Identified Peptides Year(Publication ID)
448 VLPVnVTD 2014(33);
448 VLPVnVTDY 2014(33);
448 VnVTDYCQL 2014(33);
448 nVTDYCQLVR 2015(1);
448 VLPVnVTDYCQ 2009(64); 2014(33);
448 VnVTDYCQLVR 2014(14); 2014(33); 2015(unpublished);2015(unpublished);
448 VLPVnVTDYCQL 2014(33);
448 VnVTDYCQLVRY 2014(33);
448 PRVIPVnVTDYCQ 2013(37);
448 VIPVnVTDYCQIVR 2014(32); 2014(32);
448 VLPVnVTDYCQLVR 2007(62); 2009(62); 2009(64); 2009(54); 2011(55); 2011(3); 2012(48); 2012(34); 2013(34); 2013(40); 2013(13); 2014(14); 2014(17); 2014(19); 2014(22); 2014(33); 2014(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2007;2007;2007;2007;20072007 ;
448 RVLPVnVTDYCQLVR 2015(unpublished);
1067 nCTDIDE 2014(33);
1067 RnCTDIDE 2014(33);
1067 nCTDIDECR 2011(54); 2012(48); 2013(40); 2014(14); 2014(22); 2014(33); 2015(1); 2015(unpublished);2015(unpublished);2007(unpublished);2007(unpublished);2007(Unpublished ); 2007;2007 ;
1067 RnCTDIDECR 2014(33);
1067 ERnCTDIDECR 2014(33);
1067 SEERnCTDIDE 2014(33);
1067 IDSEERnCTDIDE 2013(37);
1067 SEERnCTDIDECR 2014(33);
1067 DSEERnCTDIDECR 2012(3); 2014(33);
1067 LDSEERnCTDIDECR 2009(64);
1067 ALDSEERnCTDIDECR 2014(33);
1067 CDSGFALDSEERnCTDIDE 2014(33);
1067 CDSGFALDSEERnCTDIDECR 2014(33); 2015(unpublished);2015(12);
1067 ALDSEERnCTDIDECRISPDLCGR 2014(33);
1067 ALDSEERnCTDIDECRISPDLCGRGQ 2014(33);
1149 CECPPGHQLSPnISACIDINE 2014(33);
1149 CECPPGHQLSPnISACIDINECE 2014(33);
1149 RCECPPGHQLSPnISACIDINECELSAH 2014(33);
1149 RCECPPGHQLSPnISACIDINECELSAHL 2014(33);
1369 DIDECSnGTHMCS 2013(37);
1369 nGTHMCSQHADCK 2014(33);
1369 CSnGTHMCSQHADCK 2014(33);
1369 CTDLDECSnGTHMCSQHADCK 2012(48); 2013(38); 2014(22); 2014(33); 2015(unpublished);2015(10);
1484 SGGnCTDVNE 2014(33);
1484 DRSGGnCTDVNE 2009(64);
1484 LDRSGGnCTDVNE 2009(64); 2014(33);
1484 LDRSGGnCTDVNEC 2009(64);
1484 SGGnCTDVNECLDPT 2007(unpublished);2007(unpublished);2007(unpublished);
1484 SGGnCTDVNECLDPTTCISGN 2014(33);
1484 ELDRSGGnCTDVNECLDPTTCISGN 2014(33);
1484 SGGnCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTR 2015(unpublished);
1581 AVnTSEYK 2014(33);
1581 MCPAVnTSE 2014(33);
1581 PAVnTSEYK 2015(unpublished);
1581 CPAVnTSEYK 2014(33);
1581 EMCPAVnTSEY 2014(33);
1581 MCPAVnTSEYK 2009(64); 2014(33);
1581 EMCPAVnTSEYK 2012(48); 2015(unpublished);
1581 EMCPAVnTSEYKI 2013(37);
1581 GTPCEMCPAVnTSEY 2014(33);
1581 AWGTPCEMCPAVnTSE 2014(33);
1581 GTPCEMCPAVnTSEYK 2012(48); 2015(unpublished);
1581 AWGTPCEMCPAVnTSEY 2014(33);
1581 AWGTPCEMCPAVnTSEYK 2007(62); 2009(64); 2009(3); 2012(48); 2012(34); 2013(40); 2013(42); 2013(45); 2013(22); 2014(33); 2014(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2015;2007;2007;2007;2007;20072007 ;
1581 GTPCEMCPAVnTSEYKIL 2014(33);
1669 NTVGnY 2014(33);
1703 NYYADnQTCD 2014(33);
1703 NYYADnQTCDGE 2014(33);
1703 RNYYADnQTCDGELLF 2014(33);
1703 ADnQTCDGELLFNMTKKM 2014(33);
1703 YYADnQTCDGELLFNMTK 2015(unpublished);
1703 NYYADnQTCDGELLFNMTK 2011(58); 2012(48); 2013(40); 2013(45); 2014(14); 2014(22); 2014(33); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2015;2007;2007;2007;20072007 ;
1703 YADnQTCDGELLFNMTKKM 2014(33);
1703 NYYADnQTCDGELLFNMTKK 2012(48); 2013(34); 2013(45); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(12);
1703 RNYYADnQTCDGELLFNMTK 2015(unpublished);
1703 RNYYADnQTCDGELLFNMTKKM 2014(33);
1713 LLFnMTK 2014(33);
1713 LLFnMTKK 2014(33);
1713 GELLFnMTK 2014(33);
1713 ADNQTCDGELLFnMTKKM 2014(33);
1713 YYADNQTCDGELLFnMTK 2015(unpublished);
1713 NYYADNQTCDGELLFnMTK 2011(58); 2012(48); 2013(40); 2013(45); 2014(14); 2014(22); 2014(33); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015(UnpublishedUnpublished ); 2015;2007;2007;2007;20072007 ;
1713 YADNQTCDGELLFnMTKKM 2014(33);
1713 NYYADNQTCDGELLFnMTKK 2012(48); 2013(34); 2013(45); 2014(14); 2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(12);
1713 RNYYADNQTCDGELLFnMTK 2015(unpublished);
1713 RNYYADNQTCDGELLFnMTKKM 2014(33);
1902 DACGnGTCR 2012(3); 2012(48); 2014(22); 2014(33); 2015(unpublished);2015(unpublished);2015(Unpublished ); 2007;2007;2007 ;
2077 nHSKQECCCALK 2013(45);
2077 SRnHSKQECCCALK 2014(33);
2178 GNPCGnGTCK 2012(48);
2178 CSVGNPCGnGTCK 2014(33);
2178 CVDTDECSVGNPCGnGTCK 2014(33);
2178 NECVDTDECSVGNPCGnGTCK 2012(3);
2178 AGNECVDTDECSVGNPCGnGTCK 2015(unpublished);
2178 ILAGNECVDTDECSVGNPCGnGTCK 2012(48); 2014(33); 2015(unpublished);
2178 CECPFGYILAGNECVDTDECSVGNPCGnGTCK 2013(45); 2014(33);
2734 STnETDASNIEDQSETEANVSLASWDVEK 2013(45); 2015(unpublished);2015(unpublished);2015(unpublished);
2750 STNETDASNIEDQSETEAnVSLASWDVEK 2013(45); 2015(unpublished);2015(unpublished);2015(unpublished);
2767 AFnISHVSNK 2014(33);
2767 TAIFAFnISHVSN 2013(37);
2767 TAIFAFnISHVSNK 2007(65); 2009(65); 2009(45); 2013(2); 2015(10); 2015(12); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;

Sequence

1112131415161718191
MRRGRLLEIALGFTVLLASYTSHGADANLEAGNVKETRASRAKRRGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMC
101111121131141151161171181191
TCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLS
201211221231241251261271281291
GIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICE
301311321331341351361371381391
GGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPE
401411421431441451461471481491
YPPPPLGPIPPVLPVPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCA
501511521531541551561571581591
GGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKP
601611621631641651661671681691
GFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCP
701711721731741751761771781791
AQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKP
801811821831841851861871881891
DLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGY
901911921931941951961971981991
SRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRN
1001101110211031104110511061107110811091
TPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEG
1101111111211131114111511161117111811191
YESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDE
1201121112211231124112511261127112811291
CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTK
1301131113211331134113511361137113811391
GSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGF
1401141114211431144114511461147114811491
TCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISG
1501151115211531154115511561157115811591
NCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPI
1601161116211631164116511661167116811691
TVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYY
1701171117211731174117511761177117811791
ADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYN
1801181118211831184118511861187118811891
DKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDAC
1901191119211931194119511961197119811991
GNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCIC
2001201120212031204120512061207120812091
PPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCP
2101211121212131214121512161217121812191
TEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP
2201221122212231224122512261227122812291
MMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPG
2301231123212331234123512361237123812391
ICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG
2401241124212431244124512461247124812491
ADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLC
2501251125212531254125512561257125812591
VNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHY
2601261126212631264126512661267126812691
QWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPP
2701271127212731274127512761277127812791
VSGEMDDNSLSPEACYECKINGYPKRGRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILELLPALTTLTNHNRYLIESGNE
28012811282128312841285128612871
DGFFKINQKEGISYLHFTKKKPVAGTYSLQISSTPLYKKKELNQLEDKYDKDYLSGELGDNLKMKIQVLLH

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
3Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11.
10Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
13Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
17Fang C, Xiong Z, Qin H, Huang G, Liu J, Ye M, Feng S, Zou H: One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. Analytica Chimica Acta 2014, 841:99-105.
19Huang G, Sun Z, Qin H, Zhao L, Xiong Z, Peng X, Ou J, Zou H: Preparation of hydrazine functionalized polymer brushes hybrid magnetic nanoparticles for highly specific enrichment of glycopeptides. Analyst 2014, 139:2199-2206.
22Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
32Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837.
33Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
34Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
38Kaji H, Ocho M, Togayachi A, Kuno A, Sogabe M, Ohkura T, Nozaki H, Angata T, Chiba Y, Ozaki H, et al: Glycoproteomic Discovery of Serological Biomarker Candidates for HCV/HBV Infection-Associated Liver Fibrosis and Hepatocellular Carcinoma. Journal of Proteome Research 2013, 12:2630-2640.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
42Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.
55Tian Y, Bova GS, Zhang H: Quantitative glycoproteomic analysis of optimal cutting temperature-embedded frozen tissues identifying glycoproteins associated with aggressive prostate cancer. Analytical chemistry 2011, 83:7013-7019.
58Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
62Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968.
64Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661.
65Goo YA, Lilu AY, Ryu S, Shaffer SA, Malmstrom L, Page L, Nguyen LT, Doneanu CE, Goodlett DR: Identification of Secreted Glycoproteins of Human Prostate and Bladder Stromal Cells by Comparative Quantitative Proteomics. Prostate 2009, 69:49-61.