Detail

Contains

UniProtKB-P35590


Protein	Tyrosine-protein kinase receptor Tie-1
Gene	TIE1
Status	Reviewed
Source	Breast Cancer cell lines; Liver; Serum
Years	2013-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
83	nGSHQVTLR	2015(10);
161	SnGSYFYTLDWHEAQDGR	2015(10);
596	REnVSSPQAR	2014(33); 2015(10);
596	GQERREnVSSPQA	2013(37);

Sequence

1	11	21	31	41	51	61	71	81	91
MVWRVPPFLL	PILFLASHVG	AAVDLTLLAN	LRLTDPQRFF	LTCVSGEAGA	GRGSDAWGPP	LLLEKDDRIV	RTPPGPPLRL	ARNGSHQVTL	RGFSKPSDLV
101	111	121	131	141	151	161	171	181	191
GVFSCVGGAG	ARRTRVIYVH	NSPGAHLLPD	KVTHTVNKGD	TAVLSARVHK	EKQTDVIWKS	NGSYFYTLDW	HEAQDGRFLL	QLPNVQPPSS	GIYSATYLEA
201	211	221	231	241	251	261	271	281	291
SPLGSAFFRL	IVRGCGAGRW	GPGCTKECPG	CLHGGVCHDH	DGECVCPPGF	TGTRCEQACR	EGRFGQSCQE	QCPGISGCRG	LTFCLPDPYG	CSCGSGWRGS
301	311	321	331	341	351	361	371	381	391
QCQEACAPGH	FGADCRLQCQ	CQNGGTCDRF	SGCVCPSGWH	GVHCEKSDRI	PQILNMASEL	EFNLETMPRI	NCAAAGNPFP	VRGSIELRKP	DGTVLLSTKA
401	411	421	431	441	451	461	471	481	491
IVEPEKTTAE	FEVPRLVLAD	SGFWECRVST	SGGQDSRRFK	VNVKVPPVPL	AAPRLLTKQS	RQLVVSPLVS	FSGDGPISTV	RLHYRPQDST	MDWSTIVVDP
501	511	521	531	541	551	561	571	581	591
SENVTLMNLR	PKTGYSVRVQ	LSRPGEGGEG	AWGPPTLMTT	DCPEPLLQPW	LEGWHVEGTD	RLRVSWSLPL	VPGPLVGDGF	LLRLWDGTRG	QERRENVSSP
601	611	621	631	641	651	661	671	681	691
QARTALLTGL	TPGTHYQLDV	QLYHCTLLGP	ASPPAHVLLP	PSGPPAPRHL	HAQALSDSEI	QLTWKHPEAL	PGPISKYVVE	VQVAGGAGDP	LWIDVDRPEE
701	711	721	731	741	751	761	771	781	791
TSTIIRGLNA	STRYLFRMRA	SIQGLGDWSN	TVEESTLGNG	LQAEGPVQES	RAAEEGLDQQ	LILAVVGSVS	ATCLTILAAL	LTLVCIRRSC	LHRRRTFTYQ
801	811	821	831	841	851	861	871	881	891
SGSGEETILQ	FSSGTLTLTR	RPKLQPEPLS	YPVLEWEDIT	FEDLIGEGNF	GQVIRAMIKK	DGLKMNAAIK	MLKEYASEND	HRDFAGELEV	LCKLGHHPNI
901	911	921	931	941	951	961	971	981	991
INLLGACKNR	GYLYIAIEYA	PYGNLLDFLR	KSRVLETDPA	FAREHGTAST	LSSRQLLRFA	SDAANGMQYL	SEKQFIHRDL	AARNVLVGEN	LASKIADFGL
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
SRGEEVYVKK	TMGRLPVRWM	AIESLNYSVY	TTKSDVWSFG	VLLWEIVSLG	GTPYCGMTCA	ELYEKLPQGY	RMEQPRNCDD	EVYELMRQCW	RDRPYERPPF
1101	1111	1121	1131
AQIALQLGRM	LEARKAYVNM	SLFENFTYAG	IDATAEEA

Reference

ID	Publication
10	Tan ZJ, Yin HD, Nie S, Lin ZX, Zhu JH, Ruffin MT, Anderson MA, Simone DM, Lubman DM: Large-Scale Identification of Core-Fucosylated Glycopeptide Sites in Pancreatic Cancer Serum Using Mass Spectrometry. Journal of Proteome Research 2015, 14:1968-1978.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.