| Protein | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| Gene | CEACAM6 |
| Status | Reviewed |
| Source | Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); HCCLM3 cell line (Liver); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate tumor; SW1990 cell line (Pancreatic cancer); Saliva; Serum; Urine; ovarian tumor |
| Years | 2005-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 104 | ETIYPnASLL | 2014(33); |
| 104 | ETIYPnASLLIQ | 2014(33); |
| 104 | SGRETIYPnASLL | 2014(33); |
| 104 | ETIYPnASLLIQNV | 2014(14); 2015(unpublished); |
| 104 | ETIYPnASIIIQNVTQNDTGFYTIQVIK | 2014(32); |
| 104 | ETIYPnASLLIQNVTQNDTGFYTLQVIK | 2005( 81); 2014(14); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 111 | IQnVTQNDTGF | 2014(33); |
| 111 | IQnVTQNDTGFY | 2014(33); |
| 111 | ETIYPNASLLIQnV | 2014(14); 2015(unpublished); |
| 111 | ETIYPNASIIIQnVTQNDTGFYTIQVIK | 2014(32); |
| 111 | ETIYPNASLLIQnVTQNDTGFYTLQVIK | 2005( 81); 2014(14); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 115 | IQNVTQnDTGF | 2014(33); |
| 115 | IQNVTQnDTGFY | 2014(33); |
| 115 | TQnDTGFYTLQVIK | 2014(14); 2015(unpublished); |
| 115 | ETIYPNASIIIQNVTQnDTGFYTIQVIK | 2014(32); |
| 115 | ETIYPNASLLIQNVTQnDTGFYTLQVIK | 2005( 81); 2014(14); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 152 | SnNSNPVEDK | 2014(33); |
| 152 | ISSnNSNPVEDKDA | 2009(64); |
| 152 | PKPSISSnNSNPVE | 2009(64); |
| 152 | PSISSnNSNPVEDK | 2012(48); 2014(33); 2007(unpublished);2007(unpublished); |
| 152 | ISSnNSNPVEDKDAVAF | 2014(33); |
| 152 | LPKPSISSnNSNPVEDK | 2014(33); |
| 152 | LPKPSISSnNSNPVEDKD | 2013(42); |
| 152 | HVYPELPKPSISSnNSNPVE | 2009(64); |
| 152 | YPELPKPSISSnNSNPVEDK | 2014(33); |
| 152 | HVYPELPKPSISSnNSNPVEDK | 2014(33); |
| 152 | LPKPSISSnNSNPVEDKDAVAF | 2014(33); |
| 152 | YPELPKPSISSnNSNPVEDKDAVAF | 2014(33); |
| 152 | ATGQFHVYPELPKPSISSnNSNPVEDK | 2014(33); |
| 152 | HVYPELPKPSISSnNSNPVEDKDAVAF | 2014(33); |
| 152 | LPKPSISSnNSNPVEDKDAVAFTCEPE | 2014(33); |
| 152 | EATGQFHVYPELPKPSISSnNSNPVEDK | 2014(33); |
| 152 | ATGQFHVYPELPKPSISSnNSNPVEDKDAVAF | 2014(33); |
| 152 | SDIVNEEATGQFHVYPEIPKPSISSnNSNPVEDK | 2014(16); |
| 152 | SDLVNEEATGQFHVYPELPKPSISSnNSNPVEDK | 2012(52); |
| 152 | EATGQFHVYPELPKPSISSnNSNPVEDKDAVAFTCEPE | 2014(33); |
| 173 | VQnTTYLWW | 2014(33); |
| 173 | TCEPEVQnTTY | 2014(33); |
| 173 | TCEPEVQnTTYLW | 2014(33); |
| 173 | TCEPEVQnTTYLWW | 2014(33); |
| 173 | VQnTTYLWWVNGQSLPVSPR | 2014(33); |
| 173 | TCEPEVQnTTYLWWVNGQSLPVSPR | 2014(33); |
| 197 | LQLSNGnMTL | 2014(33); |
| 197 | IQISNGnMTITII | 2013(37); |
| 197 | LQLSNGnMTLTLL | 2014(33); |
| 197 | IQISNGnMTITIISVK | 2014(32); 2014(32); |
| 197 | LQLSNGnMTLTLLSVK | 2006( 77); 2007(63); 2009(54); 2011(47); 2012(48); 2012(52); 2012(40); 2013(45); 2013(33); 2014(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2007(unpublished);2007;2007;2007;2007; |
| 197 | LQLSNGnMTLTLLSVKR | 2014(33); |
| 224 | IQNPASAnR | 2014(33); |
| 224 | SAnRSDPVTL | 2014(33); |
| 224 | CEIQNPASAnR | 2014(33); |
| 224 | ECEIQNPASAnR | 2014(33); |
| 224 | QNPASAnRSDPVT | 2013(37); |
| 224 | IQNPASAnRSDPVTL | 2009(64); |
| 224 | ECEIQNPASAnRSDPVTL | 2014(33); |
| 224 | NDAGSYECEIQNPASAnR | 2011(54); 2012(47); 2012(52); 2013(40); 2014(33); 2015(unpublished);2007(unpublished);2007(unpublished);2007; |
| 224 | ECEIQNPASAnRSDPVTLN | 2014(33); |
| 224 | RNDAGSYECEIQNPASAnR | 2007(unpublished);2014(33); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished); |
| 256 | RPGENLnLSCH | 2014(33); |
| 256 | ANYRPGENLnLSCH | 2012(3); 2007(unpublished);2007(unpublished); |
| 256 | RPGENLnLSCHAASNPPAQY | 2014(33); |
| 256 | ANYRPGENLnLSCHAASNPPAQY | 2014(33); |
| 274 | SWFInGTF | 2014(33); |
| 274 | FInGTFQQSTQELF | 2014(33); |
| 274 | SWFInGTFQQSTQE | 2014(33); |
| 288 | IPnITVNNSGSY | 2014(33); |
| 288 | FIPnITVNNSGSY | 2014(33); |
| 288 | LFIPnITVNNSGSY | 2014(33); |
| 288 | ELFIPnITVNNSGSY | 2014(33); |
| 288 | QQSTQELFIPnITVNNSGSY | 2014(33); |
| 292 | IPNITVnNSGSY | 2014(33); |
| 292 | FIPNITVnNSGSY | 2014(33); |
| 292 | LFIPNITVnNSGSY | 2014(33); |
| 292 | ELFIPNITVnNSGSY | 2014(33); |
| 292 | QQSTQELFIPNITVnNSGSY | 2014(33); |
| 309 | MCQAHNSATGLnR | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MGPPSAPPCR | LHVPWKEVLL | TASLLTFWNP | PTTAKLTIES | TPFNVAEGKE | VLLLAHNLPQ | NRIGYSWYKG | ERVDGNSLIV | GYVIGTQQAT | PGPAYSGRET |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| IYPNASLLIQ | NVTQNDTGFY | TLQVIKSDLV | NEEATGQFHV | YPELPKPSIS | SNNSNPVEDK | DAVAFTCEPE | VQNTTYLWWV | NGQSLPVSPR | LQLSNGNMTL |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| TLLSVKRNDA | GSYECEIQNP | ASANRSDPVT | LNVLYGPDGP | TISPSKANYR | PGENLNLSCH | AASNPPAQYS | WFINGTFQQS | TQELFIPNIT | VNNSGSYMCQ |
| 301 | 311 | 321 | 331 | 341 | |||||
| AHNSATGLNR | TTVTMITVSG | SAPVLSAVAT | VGITIGVLAR | VALI |
| ID | Publication |
|---|---|
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 3 | Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 42 | Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450. |
| 45 | Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991. |
| 47 | Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S-H, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics 2012, 11:M112. 017558. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 54 | Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687. |
| 63 | Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |