| Protein | Fatty acid synthase |
| Gene | FASN |
| Status | Reviewed |
| Source | Breast cancer xenografts; Liver; OVCAR-3 cell line (Ovarian cancer); Prostate; Prostate tumor |
| Years | 2014-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 1476 | CVLLSnLSSTSHVPE | 2014(33); |
| 1476 | CVLLSnLSSTSHVPEVDPGSAELQK | 2014(14); 2014(33); 2015(unpublished); |
| 1945 | nISSLEGAR | 2015(1); |
| 1945 | QGVQVQVSTSnISSLEGAR | 2015(unpublished); |
| 1982 | nQTPEFFQDVCKPK | 2015(1); |
| 2076 | nDTIVSGTLPQR | 2015(1); |
| 2463 | nLSQVCDGK | 2015(1); |
| 2463 | TGGAYGEDLGADYnLSQVCDGK | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MEEVVIAGMS | GKLPESENLQ | EFWDNLIGGV | DMVTDDDRRW | KAGLYGLPRR | SGKLKDLSRF | DASFFGVHPK | QAHTMDPQLR | LLLEVTYEAI | VDGGINPDSL |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| RGTHTGVWVG | VSGSETSEAL | SRDPETLVGY | SMVGCQRAMM | ANRLSFFFDF | RGPSIALDTA | CSSSLMALQN | AYQAIHSGQC | PAAIVGGINV | LLKPNTSVQF |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| LRLGMLSPEG | TCKAFDTAGN | GYCRSEGVVA | VLLTKKSLAR | RVYATILNAG | TNTDGFKEQG | VTFPSGDIQE | QLIRSLYQSA | GVAPESFEYI | EAHGTGTKVG |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| DPQELNGITR | ALCATRQEPL | LIGSTKSNMG | HPEPASGLAA | LAKVLLSLEH | GLWAPNLHFH | SPNPEIPALL | DGRLQVVDQP | LPVRGGNVGI | NSFGFGGSNV |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| HIILRPNTQP | PPAPAPHATL | PRLLRASGRT | PEAVQKLLEQ | GLRHSQDLAF | LSMLNDIAAV | PATAMPFRGY | AVLGGERGGP | EVQQVPAGER | PLWFICSGMG |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| TQWRGMGLSL | MRLDRFRDSI | LRSDEAVKPF | GLKVSQLLLS | TDESTFDDIV | HSFVSLTAIQ | IGLIDLLSCM | GLRPDGIVGH | SLGEVACGYA | DGCLSQEEAV |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| LAAYWRGQCI | KEAHLPPGAM | AAVGLSWEEC | KQRCPPGVVP | ACHNSKDTVT | ISGPQAPVFE | FVEQLRKEGV | FAKEVRTGGM | AFHSYFMEAI | APPLLQELKK |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| VIREPKPRSA | RWLSTSIPEA | QWHSSLARTS | SAEYNVNNLV | SPVLFQEALW | HVPEHAVVLE | IAPHALLQAV | LKRGLKPSCT | IIPLMKKDHR | DNLEFFLAGI |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| GRLHLSGIDA | NPNALFPPVE | FPAPRGTPLI | SPLIKWDHSL | AWDVPAAEDF | PNGSGSPSAA | IYNIDTSSES | PDHYLVDHTL | DGRVLFPATG | YLSIVWKTLA |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| RALGLGVEQL | PVVFEDVVLH | QATILPKTGT | VSLEVRLLEA | SRAFEVSENG | NLVVSGKVYQ | WDDPDPRLFD | HPESPTPNPT | EPLFLAQAEV | YKELRLRGYD |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
| YGPHFQGILE | ASLEGDSGRL | LWKDNWVSFM | DTMLQMSILG | SAKHGLYLPT | RVTAIHIDPA | THRQKLYTLQ | DKAQVADVVV | SRWLRVTVAG | GVHISGLHTE |
| 1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
| SAPRRQQEQQ | VPILEKFCFT | PHTEEGCLSE | RAALQEELQL | CKGLVQALQT | KVTQQGLKMV | VPGLDGAQIP | RDPSQQELPR | LLSAACRLQL | NGNLQLELAQ |
| 1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
| VLAQERPKLP | EDPLLSGLLD | SPALKACLDT | AVENMPSLKM | KVVEVLAGHG | HLYSRIPGLL | SPHPLLQLSY | TATDRHPQAL | EAAQAELQQH | DVAQGQWDPA |
| 1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | 1391 |
| DPAPSALGSA | DLLVCNCAVA | ALGDPASALS | NMVAALREGG | FLLLHTLLRG | HPLGDIVAFL | TSTEPQYGQG | ILSQDAWESL | FSRVSLRLVG | LKKSFYGSTL |
| 1401 | 1411 | 1421 | 1431 | 1441 | 1451 | 1461 | 1471 | 1481 | 1491 |
| FLCRRPTPQD | SPIFLPVDDT | SFRWVESLKG | ILADEDSSRP | VWLKAINCAT | SGVVGLVNCL | RREPGGNRLR | CVLLSNLSST | SHVPEVDPGS | AELQKVLQGD |
| 1501 | 1511 | 1521 | 1531 | 1541 | 1551 | 1561 | 1571 | 1581 | 1591 |
| LVMNVYRDGA | WGAFRHFLLE | EDKPEEPTAH | AFVSTLTRGD | LSSIRWVCSS | LRHAQPTCPG | AQLCTVYYAS | LNFRDIMLAT | GKLSPDAIPG | KWTSQDSLLG |
| 1601 | 1611 | 1621 | 1631 | 1641 | 1651 | 1661 | 1671 | 1681 | 1691 |
| MEFSGRDASG | KRVMGLVPAK | GLATSVLLSP | DFLWDVPSNW | TLEEAASVPV | VYSTAYYALV | VRGRVRPGET | LLIHSGSGGV | GQAAIAIALS | LGCRVFTTVG |
| 1701 | 1711 | 1721 | 1731 | 1741 | 1751 | 1761 | 1771 | 1781 | 1791 |
| SAEKRAYLQA | RFPQLDSTSF | ANSRDTSFEQ | HVLWHTGGKG | VDLVLNSLAE | EKLQASVRCL | ATHGRFLEIG | KFDLSQNHPL | GMAIFLKNVT | FHGVLLDAFF |
| 1801 | 1811 | 1821 | 1831 | 1841 | 1851 | 1861 | 1871 | 1881 | 1891 |
| NESSADWREV | WALVQAGIRD | GVVRPLKCTV | FHGAQVEDAF | RYMAQGKHIG | KVVVQVLAEE | PEAVLKGAKP | KLMSAISKTF | CPAHKSYIIA | GGLGGFGLEL |
| 1901 | 1911 | 1921 | 1931 | 1941 | 1951 | 1961 | 1971 | 1981 | 1991 |
| AQWLIQRGVQ | KLVLTSRSGI | RTGYQAKQVR | RWRRQGVQVQ | VSTSNISSLE | GARGLIAEAA | QLGPVGGVFN | LAVVLRDGLL | ENQTPEFFQD | VCKPKYSGTL |
| 2001 | 2011 | 2021 | 2031 | 2041 | 2051 | 2061 | 2071 | 2081 | 2091 |
| NLDRVTREAC | PELDYFVVFS | SVSCGRGNAG | QSNYGFANSA | MERICEKRRH | EGLPGLAVQW | GAIGDVGILV | ETMSTNDTIV | SGTLPQRMAS | CLEVLDLFLN |
| 2101 | 2111 | 2121 | 2131 | 2141 | 2151 | 2161 | 2171 | 2181 | 2191 |
| QPHMVLSSFV | LAEKAAAYRD | RDSQRDLVEA | VAHILGIRDL | AAVNLDSSLA | DLGLDSLMSV | EVRQTLEREL | NLVLSVREVR | QLTLRKLQEL | SSKADEASEL |
| 2201 | 2211 | 2221 | 2231 | 2241 | 2251 | 2261 | 2271 | 2281 | 2291 |
| ACPTPKEDGL | AQQQTQLNLR | SLLVNPEGPT | LMRLNSVQSS | ERPLFLVHPI | EGSTTVFHSL | ASRLSIPTYG | LQCTRAAPLD | SIHSLAAYYI | DCIRQVQPEG |
| 2301 | 2311 | 2321 | 2331 | 2341 | 2351 | 2361 | 2371 | 2381 | 2391 |
| PYRVAGYSYG | ACVAFEMCSQ | LQAQQSPAPT | HNSLFLFDGS | PTYVLAYTQS | YRAKLTPGCE | AEAETEAICF | FVQQFTDMEH | NRVLEALLPL | KGLEERVAAA |
| 2401 | 2411 | 2421 | 2431 | 2441 | 2451 | 2461 | 2471 | 2481 | 2491 |
| VDLIIKSHQG | LDRQELSFAA | RSFYYKLRAA | EQYTPKAKYH | GNVMLLRAKT | GGAYGEDLGA | DYNLSQVCDG | KVSVHVIEGD | HRTLLEGSGL | ESIISIIHSS |
| 2501 | 2511 | ||||||||
| LAEPRVSVRE | G |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |