Detail


Protein	E3 SUMO-protein ligase RanBP2
Gene	RANBP2
Status	Reviewed
Source	HCC cell lines (Liver); Liver; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Urine
Years	2007-2015

Site	Identified Peptides	Year(Publication ID)
360	LLnLSR	2013(40);
1105	nVSGISFTENMGSSQQKNSGFR	2007(unpublished);
1365	nASTAKK	2007(unpublished);2007(unpublished);2007;
1636	QnQTTSAVSTPASSETSK	2014(33);
1695	QnQTTSAVSTPASSETSK	2014(33);
1918	nGTGFQAQDISGQK	2015(1);

Sequence

1	11	21	31	41	51	61	71	81	91
MRRSKADVER	YIASVQGSTP	SPRQKSMKGF	YFAKLYYEAK	EYDLAKKYIC	TYINVQERDP	KAHRFLGLLY	ELEENTDKAV	ECYRRSVELN	PTQKDLVLKI
101	111	121	131	141	151	161	171	181	191
AELLCKNDVT	DGRAKYWLER	AAKLFPGSPA	IYKLKEQLLD	CEGEDGWNKL	FDLIQSELYV	RPDDVHVNIR	LVEVYRSTKR	LKDAVAHCHE	AERNIALRSS
201	211	221	231	241	251	261	271	281	291
LEWNSCVVQT	LKEYLESLQC	LESDKSDWRA	TNTDLLLAYA	NLMLLTLSTR	DVQESRELLQ	SFDSALQSVK	SLGGNDELSA	TFLEMKGHFY	MHAGSLLLKM
301	311	321	331	341	351	361	371	381	391
GQHSSNVQWR	ALSELAALCY	LIAFQVPRPK	IKLIKGEAGQ	NLLEMMACDR	LSQSGHMLLN	LSRGKQDFLK	EIVETFANKS	GQSALYDALF	SSQSPKDTSF
401	411	421	431	441	451	461	471	481	491
LGSDDIGNID	VREPELEDLT	RYDVGAIRAH	NGSLQHLTWL	GLQWNSLPAL	PGIRKWLKQL	FHHLPHETSR	LETNAPESIC	ILDLEVFLLG	VVYTSHLQLK
501	511	521	531	541	551	561	571	581	591
EKCNSHHSSY	QPLCLPLPVC	KQLCTERQKS	WWDAVCTLIH	RKAVPGNVAK	LRLLVQHEIN	TLRAQEKHGL	QPALLVHWAE	CLQKTGSGLN	SFYDQREYIG
601	611	621	631	641	651	661	671	681	691
RSVHYWKKVL	PLLKIIKKKN	SIPEPIDPLF	KHFHSVDIQA	SEIVEYEEDA	HITFAILDAV	NGNIEDAVTA	FESIKSVVSY	WNLALIFHRK	AEDIENDALS
701	711	721	731	741	751	761	771	781	791
PEEQEECKNY	LRKTRDYLIK	IIDDSDSNLS	VVKKLPVPLE	SVKEMLNSVM	QELEDYSEGG	PLYKNGSLRN	ADSEIKHSTP	SPTRYSLSPS	KSYKYSPKTP
801	811	821	831	841	851	861	871	881	891
PRWAEDQNSL	LKMICQQVEA	IKKEMQELKL	NSSNSASPHR	WPTENYGPDS	VPDGYQGSQT	FHGAPLTVAT	TGPSVYYSQS	PAYNSQYLLR	PAANVTPTKG
901	911	921	931	941	951	961	971	981	991
PVYGMNRLPP	QQHIYAYPQQ	MHTPPVQSSS	ACMFSQEMYG	PPALRFESPA	TGILSPRGDD	YFNYNVQQTS	TNPPLPEPGY	FTKPPIAAHA	SRSAESKTIE
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
FGKTNFVQPM	PGEGLRPSLP	TQAHTTQPTP	FKFNSNFKSN	DGDFTFSSPQ	VVTQPPPAAY	SNSESLLGLL	TSDKPLQGDG	YSGAKPIPGG	QTIGPRNTFN
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
FGSKNVSGIS	FTENMGSSQQ	KNSGFRRSDD	MFTFHGPGKS	VFGTPTLETA	NKNHETDGGS	AHGDDDDDGP	HFEPVVPLPD	KIEVKTGEED	EEEFFCNRAK
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
LFRFDVESKE	WKERGIGNVK	ILRHKTSGKI	RLLMRREQVL	KICANHYISP	DMKLTPNAGS	DRSFVWHALD	YADELPKPEQ	LAIRFKTPEE	AALFKCKFEE
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
AQSILKAPGT	NVAMASNQAV	RIVKEPTSHD	NKDICKSDAG	NLNFEFQVAK	KEGSWWHCNS	CSLKNASTAK	KCVSCQNLNP	SNKELVGPPL	AETVFTPKTS
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
PENVQDRFAL	VTPKKEGHWD	CSICLVRNEP	TVSRCIACQN	TKSANKSGSS	FVHQASFKFG	QGDLPKPINS	DFRSVFSTKE	GQWDCSACLV	QNEGSSTKCA
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
ACQNPRKQSL	PATSIPTPAS	FKFGTSETSK	TLKSGFEDMF	AKKEGQWDCS	SCLVRNEANA	TRCVACQNPD	KPSPSTSVPA	PASFKFGTSE	TSKAPKSGFE
1601	1611	1621	1631	1641	1651	1661	1671	1681	1691
GMFTKKEGQW	DCSVCLVRNE	ASATKCIACQ	NPGKQNQTTS	AVSTPASSET	SKAPKSGFEG	MFTKKEGQWD	CSVCLVRNEA	SATKCIACQN	PGKQNQTTSA
1701	1711	1721	1731	1741	1751	1761	1771	1781	1791
VSTPASSETS	KAPKSGFEGM	FTKKEGQWDC	SVCLVRNEAS	ATKCIACQCP	SKQNQTTAIS	TPASSEISKA	PKSGFEGMFI	RKGQWDCSVC	CVQNESSSLK
1801	1811	1821	1831	1841	1851	1861	1871	1881	1891
CVACDASKPT	HKPIAEAPSA	FTLGSEMKLH	DSSGSQVGTG	FKSNFSEKAS	KFGNTEQGFK	FGHVDQENSP	SFMFQGSSNT	EFKSTKEGFS	IPVSADGFKF
1901	1911	1921	1931	1941	1951	1961	1971	1981	1991
GISEPGNQEK	KSEKPLENGT	GFQAQDISGQ	KNGRGVIFGQ	TSSTFTFADL	AKSTSGEGFQ	FGKKDPNFKG	FSGAGEKLFS	SQYGKMANKA	NTSGDFEKDD
2001	2011	2021	2031	2041	2051	2061	2071	2081	2091
DAYKTEDSDD	IHFEPVVQMP	EKVELVTGEE	DEKVLYSQRV	KLFRFDAEVS	QWKERGLGNL	KILKNEVNGK	LRMLMRREQV	LKVCANHWIT	TTMNLKPLSG
2101	2111	2121	2131	2141	2151	2161	2171	2181	2191
SDRAWMWLAS	DFSDGDAKLE	QLAAKFKTPE	LAEEFKQKFE	ECQRLLLDIP	LQTPHKLVDT	GRAAKLIQRA	EEMKSGLKDF	KTFLTNDQTK	VTEEENKGSG
2201	2211	2221	2231	2241	2251	2261	2271	2281	2291
TGAAGASDTT	IKPNPENTGP	TLEWDNYDLR	EDALDDSVSS	SSVHASPLAS	SPVRKNLFRF	GESTTGFNFS	FKSALSPSKS	PAKLNQSGTS	VGTDEESDVT
2301	2311	2321	2331	2341	2351	2361	2371	2381	2391
QEEERDGQYF	EPVVPLPDLV	EVSSGEENEQ	VVFSHRAKLY	RYDKDVGQWK	ERGIGDIKIL	QNYDNKQVRI	VMRRDQVLKL	CANHRITPDM	TLQNMKGTER
2401	2411	2421	2431	2441	2451	2461	2471	2481	2491
VWLWTACDFA	DGERKVEHLA	VRFKLQDVAD	SFKKIFDEAK	TAQEKDSLIT	PHVSRSSTPR	ESPCGKIAVA	VLEETTRERT	DVIQGDDVAD	ATSEVEVSST
2501	2511	2521	2531	2541	2551	2561	2571	2581	2591
SETTPKAVVS	PPKFVFGSES	VKSIFSSEKS	KPFAFGNSSA	TGSLFGFSFN	APLKSNNSET	SSVAQSGSES	KVEPKKCELS	KNSDIEQSSD	SKVKNLFASF
2601	2611	2621	2631	2641	2651	2661	2671	2681	2691
PTEESSINYT	FKTPEKAKEK	KKPEDSPSDD	DVLIVYELTP	TAEQKALATK	LKLPPTFFCY	KNRPDYVSEE	EEDDEDFETA	VKKLNGKLYL	DGSEKCRPLE
2701	2711	2721	2731	2741	2751	2761	2771	2781	2791
ENTADNEKEC	IIVWEKKPTV	EEKAKADTLK	LPPTFFCGVC	SDTDEDNGNG	EDFQSELQKV	QEAQKSQTEE	ITSTTDSVYT	GGTEVMVPSF	CKSEEPDSIT
2801	2811	2821	2831	2841	2851	2861	2871	2881	2891
KSISSPSVSS	ETMDKPVDLS	TRKEIDTDST	SQGESKIVSF	GFGSSTGLSF	ADLASSNSGD	FAFGSKDKNF	QWANTGAAVF	GTQSVGTQSA	GKVGEDEDGS
2901	2911	2921	2931	2941	2951	2961	2971	2981	2991
DEEVVHNEDI	HFEPIVSLPE	VEVKSGEEDE	EILFKERAKL	YRWDRDVSQW	KERGVGDIKI	LWHTMKNYYR	ILMRRDQVFK	VCANHVITKT	MELKPLNVSN
3001	3011	3021	3031	3041	3051	3061	3071	3081	3091
NALVWTASDY	ADGEAKVEQL	AVRFKTKEVA	DCFKKTFEEC	QQNLMKLQKG	HVSLAAELSK	ETNPVVFFDV	CADGEPLGRI	TMELFSNIVP	RTAENFRALC
3101	3111	3121	3131	3141	3151	3161	3171	3181	3191
TGEKGFGFKN	SIFHRVIPDF	VCQGGDITKH	DGTGGQSIYG	DKFEDENFDV	KHTGPGLLSM	ANQGQNTNNS	QFVITLKKAE	HLDFKHVVFG	FVKDGMDTVK
3201	3211	3221
KIESFGSPKG	SVCRRITITE	CGQI

UniProtKB-P49792

Glycosites

Sequence

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
40	Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.