Detail

Contains

UniProtKB-P54764


Protein	Ephrin type-A receptor 4
Gene	EPHA4
Status	Reviewed
Source	Breast Cancer cell lines; Breast tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); Liver; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Urine
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
235	nNSEEKDVPK	2015(1);
235	VRGSCVnNSEEKD	2013(37);
235	GSCVnNSEEKDVPK	2007(16); 2014(unpublished);2015(unpublished);2015;2015;2007;2007;
408	LLAHTnYTFE	2014(33);
545	IIGDGAnSTVLLVSVSGSVVLV	2007(unpublished);2007(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MAGIFYFALF	SCLFGICDAV	TGSRVYPANE	VTLLDSRSVQ	GELGWIASPL	EGGWEEVSIM	DEKNTPIRTY	QVCNVMEPSQ	NNWLRTDWIT	REGAQRVYIE
101	111	121	131	141	151	161	171	181	191
IKFTLRDCNS	LPGVMGTCKE	TFNLYYYESD	NDKERFIREN	QFVKIDTIAA	DESFTQVDIG	DRIMKLNTEI	RDVGPLSKKG	FYLAFQDVGA	CIALVSVRVF
201	211	221	231	241	251	261	271	281	291
YKKCPLTVRN	LAQFPDTITG	ADTSSLVEVR	GSCVNNSEEK	DVPKMYCGAD	GEWLVPIGNC	LCNAGHEERS	GECQACKIGY	YKALSTDATC	AKCPPHSYSV
301	311	321	331	341	351	361	371	381	391
WEGATSCTCD	RGFFRADNDA	ASMPCTRPPS	APLNLISNVN	ETSVNLEWSS	PQNTGGRQDI	SYNVVCKKCG	AGDPSKCRPC	GSGVHYTPQQ	NGLKTTKVSI
401	411	421	431	441	451	461	471	481	491
TDLLAHTNYT	FEIWAVNGVS	KYNPNPDQSV	SVTVTTNQAA	PSSIALVQAK	EVTRYSVALA	WLEPDRPNGV	ILEYEVKYYE	KDQNERSYRI	VRTAARNTDI
501	511	521	531	541	551	561	571	581	591
KGLNPLTSYV	FHVRARTAAG	YGDFSEPLEV	TTNTVPSRII	GDGANSTVLL	VSVSGSVVLV	VILIAAFVIS	RRRSKYSKAK	QEADEEKHLN	QGVRTYVDPF
601	611	621	631	641	651	661	671	681	691
TYEDPNQAVR	EFAKEIDASC	IKIEKVIGVG	EFGEVCSGRL	KVPGKREICV	AIKTLKAGYT	DKQRRDFLSE	ASIMGQFDHP	NIIHLEGVVT	KCKPVMIITE
701	711	721	731	741	751	761	771	781	791
YMENGSLDAF	LRKNDGRFTV	IQLVGMLRGI	GSGMKYLSDM	SYVHRDLAAR	NILVNSNLVC	KVSDFGMSRV	LEDDPEAAYT	TRGGKIPIRW	TAPEAIAYRK
801	811	821	831	841	851	861	871	881	891
FTSASDVWSY	GIVMWEVMSY	GERPYWDMSN	QDVIKAIEEG	YRLPPPMDCP	IALHQLMLDC	WQKERSDRPK	FGQIVNMLDK	LIRNPNSLKR	TGTESSRPNT
901	911	921	931	941	951	961	971	981
ALLDPSSPEF	SAVVSVGDWL	QAIKMDRYKD	NFTAAGYTTL	EAVVHVNQED	LARIGITAIT	HQNKILSSVQ	AMRTQMQQMH	GRMVPV

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
16	Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.
37	Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.