Contains      

UniProtKB-P55259

Protein Pancreatic secretory granule membrane major glycoprotein GP2
Gene GP2
Status Reviewed
Source Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Ovarian tumor; Pancreatic islets; Prostate; Prostate tumor; Urine; ovarian tumor
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
65 PCQnYTLLDEPFR 2012(48);
65 VCFDPCQnYTLLDEPFR 2012(48);
88 SQGCDKnMSGWYR 2013(37);
122 CQTDAPMWLnGTHPALGDGITNHTACAH 2012(48);
134 CQTDAPMWLNGTHPALGDGITnHTACAH 2012(48);
204 ACRPEEECLALnSTW 2012(48);
204 ACRPEEECLALnSTWGCF 2012(48);
204 ACRPEEECLALnSTWGCFC 2012(48);
204 ACRPEEECLALnSTWGCFCR 2012(48); 2007(unpublished);2007(unpublished);
216 QDLnSSDVH 2012(48); 2014(14); 2015(unpublished);
216 FCRQDInSSDVHS 2013(37);
216 QDLnSSDVHSLQPQ 2012(48);
216 nSSDVHSLQPQLDCGPR 2012(48);
216 DLnSSDVHSLQPQLDCGPR 2012(48);
216 QDLnSSDVHSLQPQLDCGPR 2007(48); 2012(52); 2012(45); 2013(14); 2014(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;
260 nCSSILQTEER 2012(48);
260 PnCSSILQTEER 2012(48);
260 AYIRDPnCSSIIQ 2013(37);
260 DPnCSSILQTEER 2011(54); 2012(48); 2012(52); 2014(14); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2007;2007;2007;
260 LRDPnCSSILQTEER 2012(48);
291 nQTHAIYK 2012(48); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);
291 NILERnQTHAIYK 2007(48); 2012(14); 2014(unpublished);2015(unpublished);2007;2007;
291 RNIIERnQTHAIY 2013(37);
342 VSLQAALQPIVSSLnVSVDGNGEFIVR 2014(14); 2015(unpublished);
362 MALFQDQnYTNPYEGDAV 2012(48);
362 MALFQDQnYTNPYEGDAVELSVESV 2014(14); 2015(unpublished);

Sequence

1112131415161718191
MPHLMERMVGSGLLWLALVSCILTQASAVQRGYGNPIEASSYGLDLDCGAPGTPEAHVCFDPCQNYTLLDEPFRSTENSAGSQGCDKNMSGWYRFVGEGG
101111121131141151161171181191
VRMSETCVQVHRCQTDAPMWLNGTHPALGDGITNHTACAHWSGNCCFWKTEVLVKACPGGYHVYRLEGTPWCNLRYCTVPRDPSTVEDKCEKACRPEEEC
201211221231241251261271281291
LALNSTWGCFCRQDLNSSDVHSLQPQLDCGPREIKVKVDKCLLGGLGLGEEVIAYLRDPNCSSILQTEERNWVSVTSPVQASACRNILERNQTHAIYKNT
301311321331341351361371381391
LSLVNDFIIRDTILNINFQCAYPLDMKVSLQAALQPIVSSLNVSVDGNGEFIVRMALFQDQNYTNPYEGDAVELSVESVLYVGAILEQGDTSRFNLVLRN
401411421431441451461471481491
CYATPTEDKADLVKYFIIRNSCSNQRDSTIHVEENGQSSESRFSVQMFMFAGHYDLVFLHCEIHLCDSLNEQCQPSCSRSQVRSEVPAIDLARVLDLGPI
501511521531
TRRGAQSPGVMNGTPSTAGFLVAWPMVLLTVLLAWLF

Reference

ID Publication
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
37Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
48Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608.
52Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
54Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687.