Contains      

UniProtKB-P98164

Protein Low-density lipoprotein receptor-related protein 2
Gene LRP2
Status Reviewed
Source HEK293 cell line (embryonic kidney); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Prostate; Prostate tumor; Serum; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
159 DCPDGADENDCQYPTCEQLTCDNGACYnTSQK 2015(unpublished);2015(unpublished);2015(unpublished);
178 DSSDEInCTEICLHNEFSCGNGECIPR 2013(45);
299 VCDGILDCPGREDEnNTSTGK 2007(45); 2013(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
300 VCDGILDCPGREDENnTSTGK 2007(45); 2013(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
341 YCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHnDSR 2013(45);
388 AnDSFGEASIIFSNGR 2013(45); 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);
388 GQYCKAnDSFGEASIIFSNGR 2015(unpublished);2015(unpublished);
866 AWSDGSHLLPVInTTLGWPNGLAIDWAASR 2013(45);
1144 nSTETCQPSQFNCPNHR 2015(1);
1144 NCnSTETCQPSQFNCPNHR 2007(45); 2013(unpublished);2007(unpublished);2007;
1144 NWVCDTDNDCGDGSDEKNCnSTETCQPSQFNCPNHR 2013(45);
1186 VGCVLnCTASQFK 2007(unpublished);2007(unpublished);2007;
1186 CIDLSFVCDGDKDCVDGSDEVGCVLnCTASQFK 2013(45);
1383 CLCPLGFLLAnDSK 2007(45); 2013(unpublished);2015(unpublished);2015;2015;2007;2007;
1496 TWSAFQnGTDR 2012(51); 2013(45); 2015(unpublished);2015(unpublished);2015(unpublished);
1496 TWSAFQnGTDRR 2015(unpublished);2015(unpublished);
1550 TVLISKnLTNPR 2015(unpublished);2015(unpublished);
1675 WHGGnQSVVMY 2007(unpublished);
1675 WHGGnQSVVMYNIQWPLGIVAVHPSK 2013(45); 2007(unpublished);
2177 InTTYR 2015(unpublished);2015(unpublished);
2224 SFLDCTnR 2013(45); 2014(15); 2015(unpublished);2015(unpublished);2015(unpublished);
2499 IYYSDYLNQMINSMAEDGSnR 2013(45); 2015(unpublished);2015(unpublished);2015(unpublished);
2499 RIYYSDYLNQMINSMAEDGSnR 2015(unpublished);2015(unpublished);
2781 DCnATTEFMCNNR 2007(45); 2013(unpublished);2015(unpublished);2015;2015;2007;2007;
2809 EFICNGVDNCHDnNTSDEK 2013(45); 2015(unpublished);2015(unpublished);
2810 EFICNGVDNCHDNnTSDEK 2013(45); 2015(unpublished);2015(unpublished);
2947 HQCQNQnCSDSEFLCVNDRPPDR 2007(45); 2013(unpublished);2007(unpublished);2007;
2947 HQCQNQnCSDSEFLCVNDRPPDRR 2013(45);
3315 nNTFCFDNPR 2015(1);
3315 MLAQHCVDAnNTFCFDNPR 2007(45); 2013(unpublished);2015(unpublished);2015;2015;2007;2007;
3315 RMLAQHCVDAnNTFCFDNPR 2015(unpublished);
3355 VGMDGTnK 2013(45);
3446 QTLVnTTHRPFDIHVYHPYR 2013(45);
3564 LGQFQCSDGnCTSPQTLCNAHQNCPDGSDEDR 2007(unpublished);2007(unpublished);2007;
4068 YnLSSER 2013(45); 2014(14); 2015(unpublished);2015(unpublished);2015(unpublished);
4068 KYnLSSER 2015(unpublished);2015(unpublished);2015(unpublished);

Sequence

1112131415161718191
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER
101111121131141151161171181191
QDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAY
201211221231241251261271281291
VCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
301311321331341351361371381391
TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSN
401411421431441451461471481491
GRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSY
501511521531541551561571581591
RVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
601611621631641651661671681691
IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTD
701711721731741751761771781791
ERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYW
801811821831841851861871881891
TDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
901911921931941951961971981991
GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGC
1001101110211031104110511061107110811091
PYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHN
1101111111211131114111511161117111811191
CPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
1201121112211231124112511261127112811291
IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMS
1301131113211331134113511361137113811391
DEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSC
1401141114211431144114511461147114811491
SQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
1501151115211531154115511561157115811591
RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWP
1601161116211631164116511661167116811691
CGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNS
1701171117211731174117511761177117811791
VNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
1801181118211831184118511861187118811891
IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKI
1901191119211931194119511961197119811991
ASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDN
2001201120212031204120512061207120812091
VPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
2101211121212131214121512161217121812191
DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK
2201221122212231224122512261227122812291
NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKI
2301231123212331234123512361237123812391
FQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
2401241124212431244124512461247124812491
LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR
2501251125212531254125512561257125812591
TVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTL
2601261126212631264126512661267126812691
YGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
2701271127212731274127512761277127812791
GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFIC
2801281128212831284128512861287128812891
NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCG
2901291129212931294129512961297129812991
HSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
3001301130213031304130513061307130813091
GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDC
3101311131213131314131513161317131813191
LDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPY
3201321132213231324132513261327132813291
LIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
3301331133213331334133513361337133813391
GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH
3401341134213431344134513461347134813491
TVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL
3501351135213531354135513561357135813591
QLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
3601361136213631364136513661367136813691
CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCN
3701371137213731374137513761377137813791
GVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHP
3801381138213831384138513861387138813891
EYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
3901391139213931394139513961397139813991
EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVF
4001401140214031404140514061407140814091
DRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSV
4101411141214131414141514161417141814191
VYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
4201421142214231424142514261427142814291
WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKF
4301431143214331434143514361437143814391
GQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCK
4401441144214431444144514461447144814491
CPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
4501451145214531454145514561457145814591
DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQ
460146114621463146414651
MENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
14Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768.
15Chen R, Seebun D, Ye M, Zou H, Figeys D: Site-specific characterization of cell membrane N-glycosylation with integrated hydrophilic interaction chromatography solid phase extraction and LC-MS/MS. Journal of Proteomics 2014, 103:194-203.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
51Yeh C-H, Chen S-H, Li D-T, Lin H-P, Huang H-J, Chang C-I, Shih W-L, Chern C-L, Shi F-K, Hsu J-L: Magnetic bead-based hydrophilic interaction liquid chromatography for glycopeptide enrichments. Journal of Chromatography A 2012, 1224:70-78.