Detail

UniProtKB-Q04912


Protein	Macrophage-stimulating protein receptor
Gene	MST1R
Status	Reviewed
Source	Breast cancer xenografts; Breast cell lines; Colorectal cancer cell line, HCT-116 (colorectal cancer); Colorectal tumor; Hela cell line (cervical cancer); IGROV-1/CP cell line (Ovarian cancer)IGROV-1/CP; LNCap/PC3 cell lines (Prostate cancer); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; SW1990 cell line (Pancreatic cancer); prostate cancer cell lines
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
419	GLDFFQSPSFCPNPPGLEALSPnTSCR	2015(12);
458	LDnVTVAHMGTMDGR	2007(75); 2012(47); 2014(22); 2015(unpublished);2015(2); 2015(unpublished);
488	nFSLGDSGQPVQR	2015(1);
488	SLNYLLYVSnFSLGDSGQPVQR	2012(52); 2015(2);
720	AVLVnGTECLLAR	2007(72); 2011(58); 2012(52); 2014(22); 2015(unpublished);
841	DPQGWVAGnLSAR	2007(72); 2007(75); 2011(58); 2012(52); 2014(22); 2015(2); 2015(unpublished);
841	LPEYVVRDPQGWVAGnLSAR	2011(58); 2015(2);

Sequence

1	11	21	31	41	51	61	71	81	91
MELLPPLPQS	FLLLLLLPAK	PAAGEDWQCP	RTPYAASRDF	DVKYVVPSFS	AGGLVQAMVT	YEGDRNESAV	FVAIRNRLHV	LGPDLKSVQS	LATGPAGDPG
101	111	121	131	141	151	161	171	181	191
CQTCAACGPG	PHGPPGDTDT	KVLVLDPALP	ALVSCGSSLQ	GRCFLHDLEP	QGTAVHLAAP	ACLFSAHHNR	PDDCPDCVAS	PLGTRVTVVE	QGQASYFYVA
201	211	221	231	241	251	261	271	281	291
SSLDAAVAAS	FSPRSVSIRR	LKADASGFAP	GFVALSVLPK	HLVSYSIEYV	HSFHTGAFVY	FLTVQPASVT	DDPSALHTRL	ARLSATEPEL	GDYRELVLDC
301	311	321	331	341	351	361	371	381	391
RFAPKRRRRG	APEGGQPYPV	LRVAHSAPVG	AQLATELSIA	EGQEVLFGVF	VTGKDGGPGV	GPNSVVCAFP	IDLLDTLIDE	GVERCCESPV	HPGLRRGLDF
401	411	421	431	441	451	461	471	481	491
FQSPSFCPNP	PGLEALSPNT	SCRHFPLLVS	SSFSRVDLFN	GLLGPVQVTA	LYVTRLDNVT	VAHMGTMDGR	ILQVELVRSL	NYLLYVSNFS	LGDSGQPVQR
501	511	521	531	541	551	561	571	581	591
DVSRLGDHLL	FASGDQVFQV	PIQGPGCRHF	LTCGRCLRAW	HFMGCGWCGN	MCGQQKECPG	SWQQDHCPPK	LTEFHPHSGP	LRGSTRLTLC	GSNFYLHPSG
601	611	621	631	641	651	661	671	681	691
LVPEGTHQVT	VGQSPCRPLP	KDSSKLRPVP	RKDFVEEFEC	ELEPLGTQAV	GPTNVSLTVT	NMPPGKHFRV	DGTSVLRGFS	FMEPVLIAVQ	PLFGPRAGGT
701	711	721	731	741	751	761	771	781	791
CLTLEGQSLS	VGTSRAVLVN	GTECLLARVS	EGQLLCATPP	GATVASVPLS	LQVGGAQVPG	SWTFQYREDP	VVLSISPNCG	YINSHITICG	QHLTSAWHLV
801	811	821	831	841	851	861	871	881	891
LSFHDGLRAV	ESRCERQLPE	QQLCRLPEYV	VRDPQGWVAG	NLSARGDGAA	GFTLPGFRFL	PPPHPPSANL	VPLKPEEHAI	KFEYIGLGAV	ADCVGINVTV
901	911	921	931	941	951	961	971	981	991
GGESCQHEFR	GDMVVCPLPP	SLQLGQDGAP	LQVCVDGECH	ILGRVVRPGP	DGVPQSTLLG	ILLPLLLLVA	ALATALVFSY	WWRRKQLVLP	PNLNDLASLD
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
QTAGATPLPI	LYSGSDYRSG	LALPAIDGLD	STTCVHGASF	SDSEDESCVP	LLRKESIQLR	DLDSALLAEV	KDVLIPHERV	VTHSDRVIGK	GHFGVVYHGE
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
YIDQAQNRIQ	CAIKSLSRIT	EMQQVEAFLR	EGLLMRGLNH	PNVLALIGIM	LPPEGLPHVL	LPYMCHGDLL	QFIRSPQRNP	TVKDLISFGL	QVARSMEYLA
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
EQKFVHRDLA	ARNCMLDESF	TVKVADFGLA	RDILDREYYS	VQQHRHARLP	VKWMALESLQ	TYRFTTKSDV	WSFGVLLWEL	LTRGAPPYRH	IDPFDLTHFL
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
AQGRRLPQPE	YCPDSLYQVM	QQCWEADPAV	RPTFRVLVGE	VEQIVSALLG	DHYVQLPATY	MNLGPSTSHE	MNVRPEQPQF	SPMPGNVRRP	RPLSEPPRPT

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
2	Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763.
12	Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
22	Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941.
47	Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen S-H, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K: Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics 2012, 11:M112. 017558.
52	Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667.
58	Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M: Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Journal of Proteomics 2011, 74:1985-1993.
72	Hanson SR, Hsu T-L, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong C-H: Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society 2007, 129:7266-+.
75	Sun B, Ranish JA, Utleg AG, White JT, Yan X, Lin B, Hood L: Shotgun glycopeptide capture approach coupled with mass Spectrometry for comprehensive glycoproteomics. Molecular & Cellular Proteomics 2007, 6:141-149.