Contains      

UniProtKB-Q06418

Protein Tyrosine-protein kinase receptor TYRO3
Gene TYRO3
Status Reviewed
Source Breast cancer xenografts; Cerebrospinal fluid; HCC cell lines (Liver); HCCLM3 cell line (Liver); Hela cell line (cervical cancer); Non-small Cell Lung Carcinoma; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Urine
Years 2007-2015

Glycosites

Site Identified Peptides Year(Publication ID)
63 LnCSVEGMEEPDIQWVK 2013(45);
63 LTVSQGQPVKLnCSVEGMEEPDIQWVK 2007(unpublished);2015(unpublished);2015;2007;2007;
191 nVTGVTQSTMFSCEAHNLK 2015(1);
191 IGGPAPSPSVLnVTGVTQSTMFSCEAHNLK 2007(45); 2013(unpublished);2007(unpublished);2007(unpublished);2007;
230 QALPAAPFnITVTK 2007(unpublished);2007(unpublished);2007;
230 TATVHLQALPAAPFnITVTK 2013(45); 2015(1);
240 nASVAWMPGADGR 2015(1);
240 LSSSnASVAWMPGADGR 2007(40); 2013(45); 2013(18); 2014(1); 2015(12); 2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;
293 DLVPATnYSLR 2007(40); 2013(45); 2013(18); 2014(1); 2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;
366 nGTQDELTVEGTR 2015(1);
366 LSWVQDnGTQDELTVEGTR 2015(unpublished);2015(unpublished);
380 AnLTGWDPQK 2007(63); 2009(40); 2013(45); 2013(unpublished);2015(unpublished);2015;2007;2007;
380 AnLTGWDPQKDLIVR 2013(45); 2015(unpublished);2015(unpublished);2015(12);

Sequence

1112131415161718191
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIG
101111121131141151161171181191
FLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTM
201211221231241251261271281291
FSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
301311321331341351361371381391
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAV
401411421431441451461471481491
GCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGI
501511521531541551561571581591
SDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
601611621631641651661671681691
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLA
701711721731741751761771781791
LESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQ
801811821831841851861871881
DPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC

Reference

ID Publication
1Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
12Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
18Hirao Y, Matsuzaki H, Iwaki J, Kuno A, Kaji H, Ohkura T, Togayachi A, Abe M, Nomura M, Noguchi M, et al: Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma. Journal of Proteome Research 2014, 13:4705-4716.
40Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8.
45Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.
63Cao J, Shen C, Wang H, Shen H, Chen Y, Nie A, Yan G, Lu H, Liu Y, Yang P: Identification of N-Glycosylation Sites on Secreted Proteins of Human Hepatocellular Carcinoma Cells with a Complementary Proteomics Approach. Journal of Proteome Research 2009, 8:662-672.