Detail

UniProtKB-Q13219


Protein	Pappalysin-1
Gene	PAPPA
Status	Reviewed
Source	Hela cell line (cervical cancer); Human; Liver; Serum
Years	2014-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
429	IGDENCDPECnHTLTGHDGGDCR	2014(33); 2015(12);
480	ITnVTQTCFDPDSPHR	2014(33);
480	GGECCDPEITnVTQTCFDPD	2015(6);
601	TGDLCnDTNPAPK	2014(33);
619	SCGDPGPGnDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVAR	2015(unpublished);
725	ILVQYASnASSPMPCSPSGHWSPR	2015(unpublished);
825	nISLGPQNVFCDVPLTIR	2015(12);
1465	KDGTWnGSFHVCQE	2014(33);
1519	SIILPMnVTVR	2014(33);
1519	LQCPDGYAIGSECATSCLDHNSESIILPMnVTVR	2015(unpublished);

Sequence

1	11	21	31	41	51	61	71	81	91
MRLWSWVLHL	GLLSAALGCG	LAERPRRARR	DPRAGRPPRP	AAGPATCATR	AARGRRASPP	PPPPPGGAWE	AVRVPRRRQQ	REARGATEEP	SPPSRALYFS
101	111	121	131	141	151	161	171	181	191
GRGEQLRLRA	DLELPRDAFT	LQVWLRAEGG	QRSPAVITGL	YDKCSYISRD	RGWVVGIHTI	SDQDNKDPRY	FFSLKTDRAR	QVTTINAHRS	YLPGQWVYLA
201	211	221	231	241	251	261	271	281	291
ATYDGQFMKL	YVNGAQVATS	GEQVGGIFSP	LTQKCKVLML	GGSALNHNYR	GYIEHFSLWK	VARTQREILS	DMETHGAHTA	LPQLLLQENW	DNVKHAWSPM
301	311	321	331	341	351	361	371	381	391
KDGSSPKVEF	SNAHGFLLDT	SLEPPLCGQT	LCDNTEVIAS	YNQLSSFRQP	KVVRYRVVNL	YEDDHKNPTV	TREQVDFQHH	QLAEAFKQYN	ISWELDVLEV
401	411	421	431	441	451	461	471	481	491
SNSSLRRRLI	LANCDISKIG	DENCDPECNH	TLTGHDGGDC	RHLRHPAFVK	KQHNGVCDMD	CNYERFNFDG	GECCDPEITN	VTQTCFDPDS	PHRAYLDVNE
501	511	521	531	541	551	561	571	581	591
LKNILKLDGS	THLNIFFAKS	SEEELAGVAT	WPWDKEALMH	LGGIVLNPSF	YGMPGHTHTM	IHEIGHSLGL	YHVFRGISEI	QSCSDPCMET	EPSFETGDLC
601	611	621	631	641	651	661	671	681	691
NDTNPAPKHK	SCGDPGPGND	TCGFHSFFNT	PYNNFMSYAD	DDCTDSFTPN	QVARMHCYLD	LVYQGWQPSR	KPAPVALAPQ	VLGHTTDSVT	LEWFPPIDGH
701	711	721	731	741	751	761	771	781	791
FFERELGSAC	HLCLEGRILV	QYASNASSPM	PCSPSGHWSP	REAEGHPDVE	QPCKSSVRTW	SPNSAVNPHT	VPPACPEPQG	CYLELEFLYP	LVPESLTIWV
801	811	821	831	841	851	861	871	881	891
TFVSTDWDSS	GAVNDIKLLA	VSGKNISLGP	QNVFCDVPLT	IRLWDVGEEV	YGIQIYTLDE	HLEIDAAMLT	STADTPLCLQ	CKPLKYKVVR	DPPLQMDVAS
901	911	921	931	941	951	961	971	981	991
ILHLNRKFVD	MDLNLGSVYQ	YWVITISGTE	ESEPSPAVTY	IHGSGYCGDG	IIQKDQGEQC	DDMNKINGDG	CSLFCRQEVS	FNCIDEPSRC	YFHDGDGVCE
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
EFEQKTSIKD	CGVYTPQGFL	DQWASNASVS	HQDQQCPGWV	IIGQPAASQV	CRTKVIDLSE	GISQHAWYPC	TISYPYSQLA	QTTFWLRAYF	SQPMVAAAVI
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
VHLVTDGTYY	GDQKQETISV	QLLDTKDQSH	DLGLHVLSCR	NNPLIIPVVH	DLSQPFYHSQ	AVRVSFSSPL	VAISGVALRS	FDNFDPVTLS	SCQRGETYSP
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
AEQSCVHFAC	EKTDCPELAV	ENASLNCSSS	DRYHGAQCTV	SCRTGYVLQI	RRDDELIKSQ	TGPSVTVTCT	EGKWNKQVAC	EPVDCSIPDH	HQVYAASFSC
1301	1311	1321	1331	1341	1351	1361	1371	1381	1391
PEGTTFGSQC	SFQCRHPAQL	KGNNSLLTCM	EDGLWSFPEA	LCELMCLAPP	PVPNADLQTA	RCRENKHKVG	SFCKYKCKPG	YHVPGSSRKS	KKRAFKTQCT
1401	1411	1421	1431	1441	1451	1461	1471	1481	1491
QDGSWQEGAC	VPVTCDPPPP	KFHGLYQCTN	GFQFNSECRI	KCEDSDASQG	LGSNVIHCRK	DGTWNGSFHV	CQEMQGQCSV	PNELNSNLKL	QCPDGYAIGS
1501	1511	1521	1531	1541	1551	1561	1571	1581	1591
ECATSCLDHN	SESIILPMNV	TVRDIPHWLN	PTRVERVVCT	AGLKWYPHPA	LIHCVKGCEP	FMGDNYCDAI	NNRAFCNYDG	GDCCTSTVKT	KKVTPFPMSC
1601	1611	1621
DLQGDCACRD	PQAQEHSRKD	LRGYSHG

Reference

ID	Publication
6	Kim DS, Hahn Y: The acquisition of novel N-glycosylation sites in conserved proteins during human evolution. Bmc Bioinformatics 2015, 16.
12	Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5.
33	Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721.