| Protein | Disintegrin and metalloproteinase domain-containing protein 15 |
| Gene | ADAM15 |
| Status | Reviewed |
| Source | Breast Cancer cell lines; Breast cancer xenografts; Colorectal tumor; DLBCL cell lines (Diffuse large B-cell lymphoma); HCC cell lines (Liver); Hela cell line (cervical cancer); LNCap/PC3 cell lines (Prostate cancer); Liver; OVCAR-3 cell line (Ovarian cancer); prostate cancer cell lines |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 237 | LLnRTL | 2014(33); |
| 237 | DFQHIInR | 2014(16); |
| 237 | DFQHLLnR | 2007(72); 2013(40); 2014(22); 2014(33); 2015(1); 2015(2); 2015(unpublished); |
| 237 | YRDFQHLLnR | 2007(72); 2015(1); 2015(2); 2015(unpublished); |
| 237 | DFQHIInRTIEVA | 2013(37); |
| 389 | ASTDFLPGLnFSNCSR | 2014(33); |
| 389 | TCIMEASTDFLPGLnFSNCSR | 2007(72); 2015(unpublished);2015(12); |
| 392 | ASTDFLPGLNFSnCSR | 2014(33); |
| 392 | TCIMEASTDFLPGLNFSnCSR | 2007(72); 2015(unpublished);2015(12); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MRLALLWALG | LLGAGSPLPS | WPLPNIGGTE | EQQAESEKAP | REPLEPQVLQ | DDLPISLKKV | LQTSLPEPLR | IKLELDGDSH | ILELLQNREL | VPGRPTLVWY |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| QPDGTRVVSE | GHTLENCCYQ | GRVRGYAGSW | VSICTCSGLR | GLVVLTPERS | YTLEQGPGDL | QGPPIISRIQ | DLHLPGHTCA | LSWRESVHTQ | KPPEHPLGQR |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| HIRRRRDVVT | ETKTVELVIV | ADHSEAQKYR | DFQHLLNRTL | EVALLLDTFF | RPLNVRVALV | GLEAWTQRDL | VEISPNPAVT | LENFLHWRRA | HLLPRLPHDS |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| AQLVTGTSFS | GPTVGMAIQN | SICSPDFSGG | VNMDHSTSIL | GVASSIAHEL | GHSLGLDHDL | PGNSCPCPGP | APAKTCIMEA | STDFLPGLNF | SNCSRRALEK |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| ALLDGMGSCL | FERLPSLPPM | AAFCGNMFVE | PGEQCDCGFL | DDCVDPCCDS | LTCQLRPGAQ | CASDGPCCQN | CQLRPSGWQC | RPTRGDCDLP | EFCPGDSSQC |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| PPDVSLGDGE | PCAGGQAVCM | HGRCASYAQQ | CQSLWGPGAQ | PAAPLCLQTA | NTRGNAFGSC | GRNPSGSYVS | CTPRDAICGQ | LQCQTGRTQP | LLGSIRDLLW |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| ETIDVNGTEL | NCSWVHLDLG | SDVAQPLLTL | PGTACGPGLV | CIDHRCQRVD | LLGAQECRSK | CHGHGVCDSN | RHCYCEEGWA | PPDCTTQLKA | TSSLTTGLLL |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| SLLVLLVLVM | LGASYWYRAR | LHQRLCQLKG | PTCQYRAAQS | GPSERPGPPQ | RALLARGTKQ | ASALSFPAPP | SRPLPPDPVS | KRLQAELADR | PNPPTRPLPA |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | |||
| DPVVRSPKSQ | GPAKPPPPRK | PLPADPQGRC | PSGDLPGPGA | GIPPLVVPSR | PAPPPPTVSS | LYL |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 12 | Weng Y, Sui Z, Jiang H, Shan Y, Chen L, Zhang S, Zhang L, Zhang Y: Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation. Scientific Reports 2015, 5. |
| 16 | Deeb SJ, Cox J, Schmidt-Supprian M, Mann M: N-linked Glycosylation Enrichment for In-depth Cell Surface Proteomics of Diffuse Large B-cell Lymphoma Subtypes. Molecular & Cellular Proteomics 2014, 13:240-251. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 40 | Li X, Jiang J, Zhao X, Wang J, Han H, Zhao Y, Peng B, Zhong R, Ying W, Qian X: N-glycoproteome Analysis of the Secretome of Human Metastatic Hepatocellular Carcinoma Cell Lines Combining Hydrazide Chemistry, HILIC Enrichment and Mass Spectrometry. Plos One 2013, 8. |
| 72 | Hanson SR, Hsu T-L, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong C-H: Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society 2007, 129:7266-+. |