| Protein | Transmembrane glycoprotein NMB |
| Gene | GPNMB |
| Status | Reviewed |
| Source | Breast Cancer cell lines; Breast cancer xenografts; Breast cell lines; Breast tumor; Colorectal tumor; DRO-1 Cell Line (Thyroid Cance); LNCap/PC3 cell lines (Prostate cancer); Liver; Liver tumor (HCC); OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Pancreatic islets; Plasma; Prostate; Prostate tumor; Serum; Urine; XTC-1 Cell Line (Thyroid Cance); ovarian tumor |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 93 | SDSPALVGSnITF | 2014(33); |
| 93 | TSDSPALVGSnITF | 2014(33); |
| 93 | AVLTSDSPALVGSnITF | 2014(33); |
| 93 | TSDSPALVGSnITFAVNL | 2014(33); |
| 93 | VQAVLTSDSPALVGSnITF | 2014(33); |
| 93 | VQAVLTSDSPALVGSnITFAVNLIFPR | 2014(33); 2015(unpublished);2015(1); |
| 200 | VSVNTAnVTIGPQ | 2013(37); |
| 200 | VSVNTAnVTLGPQL | 2014(33); |
| 200 | nVTLGPQLMEVTVYR | 2015(1); |
| 200 | VSVNTAnVTLGPQLM | 2015(unpublished); |
| 200 | TAnVTLGPQLMEVTVY | 2014(33); |
| 200 | VSVNTAnVTLGPQLME | 2014(33); |
| 200 | TAnVTLGPQLMEVTVYR | 2015(unpublished); |
| 200 | VNTAnVTLGPQLMEVTVY | 2014(33); |
| 200 | VSVNTAnVTLGPQLMEVTVY | 2012(48); 2014(33); |
| 200 | VSVNTAnVTIGPQIMEVTVYR | 2014(32); |
| 200 | VSVNTAnVTLGPQLMEVTVYR | 2007(62); 2009(62); 2009(64); 2009(54); 2011(52); 2012(34); 2013(34); 2013(14); 2014(22); 2014(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2007;2007;2007;2007;2007; |
| 200 | RVSVNTAnVTLGPQLMEVTVYR | 2015(unpublished); |
| 200 | VSVNTAnVTLGPQLMEVTVYRR | 2012(52); |
| 249 | DRnSSDETF | 2014(33); |
| 249 | nSSDETFLK | 2014(22); 2014(33); 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished); |
| 249 | RnSSDETFLK | 2014(14); 2014(33); 2015(unpublished); |
| 249 | DRnSSDETFLK | 2012(48); 2014(14); 2014(33); 2015(unpublished); |
| 249 | NDRnSSDETFIK | 2014(32); |
| 249 | NDRnSSDETFLK | 2007(64); 2009(3); 2012(48); 2012(52); 2012(34); 2013(34); 2013(13); 2014(14); 2014(22); 2014(33); 2014(1); 2015(unpublished);2015(unpublished);2015(unpublished);2015(unpublished);2015;2015;2015;2007;2007;2007;2007; |
| 249 | QKNDRnSSDETF | 2014(33); |
| 249 | FQKNDRnSSDETF | 2009(64); 2013(37); |
| 249 | DRnSSDETFLKDLPIMF | 2014(33); |
| 275 | nYSTINYK | 2015(1); |
| 275 | IHDPSHFLnY | 2014(33); |
| 275 | VLIHDPSHFLnY | 2014(33); |
| 275 | DVLIHDPSHFLnY | 2014(33); |
| 275 | PSHFLnYSTINYK | 2015(unpublished); |
| 275 | IHDPSHFLnYSTINY | 2014(33); |
| 275 | IHDPSHFLnYSTINYK | 2014(33); 2015(unpublished); |
| 275 | VLIHDPSHFLnYSTINY | 2014(33); |
| 275 | DVLIHDPSHFLnYSTINY | 2014(33); |
| 275 | VLIHDPSHFLnYSTINYK | 2014(33); |
| 275 | DLPIMFDVLIHDPSHFLnY | 2015(unpublished); |
| 275 | DVLIHDPSHFLnYSTINYK | 2012(48); 2014(33); |
| 275 | MFDVLIHDPSHFLnYSTINYK | 2015(unpublished); |
| 275 | DLPIMFDVLIHDPSHFLnYSTIN | 2015(unpublished); |
| 275 | DLPIMFDVLIHDPSHFLnYSTINYK | 2007(64); 2009(52); 2012(33); 2014(1); 2015(2); 2015(unpublished);2015(unpublished);2015;2015;2007;2007; |
| 296 | nHTVNHTYVL | 2015(1); |
| 296 | VSTnHTVNHTY | 2009(64); 2014(33); |
| 296 | VSTnHTVNHTYVLNGTF | 2014(33); |
| 296 | FVSTnHTVNHTYVLNGTF | 2009(64); |
| 300 | NHTVnHTYVL | 2015(1); |
| 300 | VSTNHTVnHTY | 2009(64); 2014(33); |
| 300 | VSTNHTVnHTYVLNGTF | 2014(33); |
| 300 | FVSTNHTVnHTYVLNGTF | 2009(64); |
| 306 | VSTNHTVNHTYVLnGTF | 2014(33); |
| 306 | FVSTNHTVNHTYVLnGTF | 2009(64); |
| 312 | SLnLTVK | 2014(33); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MECLYYFLGF | LLLAARLPLD | AAKRFHDVLG | NERPSAYMRE | HNQLNGWSSD | ENDWNEKLYP | VWKRGDMRWK | NSWKGGRVQA | VLTSDSPALV | GSNITFAVNL |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| IFPRCQKEDA | NGNIVYEKNC | RNEAGLSADP | YVYNWTAWSE | DSDGENGTGQ | SHHNVFPDGK | PFPHHPGWRR | WNFIYVFHTL | GQYFQKLGRC | SVRVSVNTAN |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| VTLGPQLMEV | TVYRRHGRAY | VPIAQVKDVY | VVTDQIPVFV | TMFQKNDRNS | SDETFLKDLP | IMFDVLIHDP | SHFLNYSTIN | YKWSFGDNTG | LFVSTNHTVN |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| HTYVLNGTFS | LNLTVKAAAP | GPCPPPPPPP | RPSKPTPSLA | TTLKSYDSNT | PGPAGDNPLE | LSRIPDENCQ | INRYGHFQAT | ITIVEGILEV | NIIQMTDVLM |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| PVPWPESSLI | DFVVTCQGSI | PTEVCTIISD | PTCEITQNTV | CSPVDVDEMC | LLTVRRTFNG | SGTYCVNLTL | GDDTSLALTS | TLISVPDRDP | ASPLRMANSA |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | ||
| LISVGCLAIF | VTVISLLVYK | KHKEYNPIEN | SPGNVVRSKG | LSVFLNRAKA | VFFPGNQEKD | PLLKNQEFKG | VS |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 2 | Shah P, Wang X, Yang W, Eshghi ST, Sun S, Hoti N, Chen L, Yang S, Pasay J, Rubin A: Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveal Glycoprotein Alteration in Protein Abundance and Glycosylation. Molecular & Cellular Proteomics 2015, 14:2753-2763. |
| 3 | Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H: Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical proteomics 2015, 12:11. |
| 13 | Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153. |
| 14 | Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R: Glycoproteomic analysis of prostate cancer tissues by SWATH mass spectrometry discovers N-acylethanolamine acid amidase and protein tyrosine kinase 7 as signatures for tumor aggressiveness. Molecular & Cellular Proteomics 2014, 13:1753-1768. |
| 22 | Nicastri A, Gaspari M, Sacco R, Elia L, Gabriele C, Romano R, Rizzuto A, Cuda G: N-Glycoprotein Analysis Discovers New Up-Regulated Glycoproteins in Colorectal Cancer Tissue. Journal of Proteome Research 2014, 13:4932-4941. |
| 32 | Zhang Z, Sun Z, Zhu J, Liu J, Huang G, Ye M, Zou H: High-Throughput Determination of the Site-Specific N-Sialoglycan Occupancy Rates by Differential Oxidation of Glycoproteins Followed with Quantitative Glycoproteomics Analysis. Analytical Chemistry 2014, 86:9830-9837. |
| 33 | Zhu J, Sun Z, Cheng K, Chen R, Ye M, Xu B, Sun D, Wang L, Liu J, Wang F, Zou H: Comprehensive Mapping of Protein N-Glycosylation in Human Liver by Combining Hydrophilic Interaction Chromatography and Hydrazide Chemistry. Journal of Proteome Research 2014, 13:1713-1721. |
| 34 | Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615. |
| 37 | Boersema PJ, Geiger T, Wisniewski JR, Mann M: Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples. Molecular & Cellular Proteomics 2013, 12:158-171. |
| 48 | Danzer C, Eckhardt K, Schmidt A, Fankhauser N, Ribrioux S, Wollscheid B, Mueller L, Schiess R, Zuellig R, Lehmann R, et al: Comprehensive Description of the N-Glycoproteome of Mouse Pancreatic beta-Cells and Human Islets. Journal of Proteome Research 2012, 11:1598-1608. |
| 52 | Yen T-Y, Macher BA, McDonald CA, Alleyne-Chin C, Timpe LC: Glycoprotein Profiles of Human Breast Cells Demonstrate a Clear Clustering of Normal/Benign versus Malignant Cell Lines and Basal versus Luminal Cell Lines. Journal of Proteome Research 2012, 11:656-667. |
| 54 | Tian Y, Yao Z, Roden R, Zhang H: Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics. Proteomics 2011, 11:4677-4687. |
| 62 | Arcinas A, Yen T-Y, Kebebew E, Macher BA: Cell Surface and Secreted Protein Profiles of Human Thyroid Cancer Cell Lines Reveal Distinct Glycoprotein Patterns. Journal of Proteome Research 2009, 8:3958-3968. |
| 64 | Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res 2009, 8:651-661. |