Detail

UniProtKB-Q15303


Protein	Receptor tyrosine-protein kinase erbB-4
Gene	ERBB4
Status	Reviewed
Source	Breast cancer xenografts; OVCAR-3 cell line (Ovarian cancer); Ovarian tumor; Plasma; Prostate tumor; Serum; Urine
Years	2007-2015

Glycosites

Site	Identified Peptides	Year(Publication ID)
138	nLTEILNGGVYVDQNK	2013(34); 2014(13); 2015(unpublished);2015(1); 2015(unpublished);2015(unpublished);
174	nLTLVSTNGSSGCGR	2015(1);
174	NPWPSnLTLVSTNGSSGCGR	2015(1); 2015(unpublished);
181	NLTLVSTnGSSGCGR	2015(1);
181	NPWPSNLTLVSTnGSSGCGR	2015(1); 2015(unpublished);
253	DTDCFACMNFnDSGACVTQCPQTFVYNPTTFQLEHNFNAK	2015(unpublished);
358	ACDGIGTGSLMSAQTVDSSNIDKFInCTK	2015(1);
473	nWTTLFSTINQR	2015(1);
548	nGSICVECDPQCEK	2015(1);
548	EFEnGSICVECDPQCEK	2015(unpublished);2015(1);
576	MEDGLLTCHGPGPDnCTK	2007(45); 2013(unpublished);2007(unpublished);2007;

Sequence

1	11	21	31	41	51	61	71	81	91
MKPATGLWVW	VSLLVAAGTV	QPSDSQSVCA	GTENKLSSLS	DLEQQYRALR	KYYENCEVVM	GNLEITSIEH	NRDLSFLRSV	REVTGYVLVA	LNQFRYLPLE
101	111	121	131	141	151	161	171	181	191
NLRIIRGTKL	YEDRYALAIF	LNYRKDGNFG	LQELGLKNLT	EILNGGVYVD	QNKFLCYADT	IHWQDIVRNP	WPSNLTLVST	NGSSGCGRCH	KSCTGRCWGP
201	211	221	231	241	251	261	271	281	291
TENHCQTLTR	TVCAEQCDGR	CYGPYVSDCC	HRECAGGCSG	PKDTDCFACM	NFNDSGACVT	QCPQTFVYNP	TTFQLEHNFN	AKYTYGAFCV	KKCPHNFVVD
301	311	321	331	341	351	361	371	381	391
SSSCVRACPS	SKMEVEENGI	KMCKPCTDIC	PKACDGIGTG	SLMSAQTVDS	SNIDKFINCT	KINGNLIFLV	TGIHGDPYNA	IEAIDPEKLN	VFRTVREITG
401	411	421	431	441	451	461	471	481	491
FLNIQSWPPN	MTDFSVFSNL	VTIGGRVLYS	GLSLLILKQQ	GITSLQFQSL	KEISAGNIYI	TDNSNLCYYH	TINWTTLFST	INQRIVIRDN	RKAENCTAEG
501	511	521	531	541	551	561	571	581	591
MVCNHLCSSD	GCWGPGPDQC	LSCRRFSRGR	ICIESCNLYD	GEFREFENGS	ICVECDPQCE	KMEDGLLTCH	GPGPDNCTKC	SHFKDGPNCV	EKCPDGLQGA
601	611	621	631	641	651	661	671	681	691
NSFIFKYADP	DRECHPCHPN	CTQGCNGPTS	HDCIYYPWTG	HSTLPQHART	PLIAAGVIGG	LFILVIVGLT	FAVYVRRKSI	KKKRALRRFL	ETELVEPLTP
701	711	721	731	741	751	761	771	781	791
SGTAPNQAQL	RILKETELKR	VKVLGSGAFG	TVYKGIWVPE	GETVKIPVAI	KILNETTGPK	ANVEFMDEAL	IMASMDHPHL	VRLLGVCLSP	TIQLVTQLMP
801	811	821	831	841	851	861	871	881	891
HGCLLEYVHE	HKDNIGSQLL	LNWCVQIAKG	MMYLEERRLV	HRDLAARNVL	VKSPNHVKIT	DFGLARLLEG	DEKEYNADGG	KMPIKWMALE	CIHYRKFTHQ
901	911	921	931	941	951	961	971	981	991
SDVWSYGVTI	WELMTFGGKP	YDGIPTREIP	DLLEKGERLP	QPPICTIDVY	MVMVKCWMID	ADSRPKFKEL	AAEFSRMARD	PQRYLVIQGD	DRMKLPSPND
1001	1011	1021	1031	1041	1051	1061	1071	1081	1091
SKFFQNLLDE	EDLEDMMDAE	EYLVPQAFNI	PPPIYTSRAR	IDSNRSEIGH	SPPPAYTPMS	GNQFVYRDGG	FAAEQGVSVP	YRAPTSTIPE	APVAQGATAE
1101	1111	1121	1131	1141	1151	1161	1171	1181	1191
IFDDSCCNGT	LRKPVAPHVQ	EDSSTQRYSA	DPTVFAPERS	PRGELDEEGY	MTPMRDKPKQ	EYLNPVEENP	FVSRRKNGDL	QALDNPEYHN	ASNGPPKAED
1201	1211	1221	1231	1241	1251	1261	1271	1281	1291
EYVNEPLYLN	TFANTLGKAE	YLKNNILSMP	EKAKKAFDNP	DYWNHSLPPR	STLQHPDYLQ	EYSTKYFYKQ	NGRIRPIVAE	NPEYLSEFSL	KPGTVLPPPP
1301
YRHRNTVV

Reference

ID	Publication
1	Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication.
13	Yang W, Laeyendecker O, Wendel SK, Zhang B, Sun S, Zhou J-Y, Ao M, Moore RD, Jackson JB, Zhang H: Glycoproteomic Study Reveals Altered Plasma Proteins Associated with HIV Elite Suppressors. Theranostics 2014, 4:1153.
34	Sun S, Zhang B, Aiyetan P, Zhou J-Y, Shah P, Yang W, Levine DA, Zhang Z, Chan DW, Zhang H: Analysis of N-glycoproteins using Genomic N-glycosite Prediction. Journal of Proteome Research 2013, 12:5609-5615.
45	Zhou H, Froehlich JW, Briscoe AC, Lee RS: The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment. Molecular & Cellular Proteomics 2013, 12:2981-2991.