| Protein | Probable E3 ubiquitin-protein ligase HERC1 |
| Gene | HERC1 |
| Status | Reviewed |
| Source | Breast tumor; OVCAR-3 cell line (Ovarian cancer); Prostate tumor; Serum; Urine |
| Years | 2007-2015 |
| Site | Identified Peptides | Year(Publication ID) |
|---|---|---|
| 17 | nSSWITEDSESIATR | 2007(unpublished);2007(unpublished);2007; |
| 1043 | HLQLLLPHATDIYSRSANLLKESPWnGSVGEK | 2013(42); |
| 4045 | nGTVLACGEGSYGR | 2015(1); |
| 4223 | LGLGnSTAK | 2015(unpublished);2015(unpublished); |
| 4552 | ELETGIVDLLIPSPnATAEVGYNR | 2007(unpublished);2007(unpublished);2007(unpublished); |
| 1 | 11 | 21 | 31 | 41 | 51 | 61 | 71 | 81 | 91 |
| MATMIPPVKL | KWLEHLNSSW | ITEDSESIAT | REGVAVLYSK | LVSNKEVVPL | PQQVLCLKGP | QLPDFERESL | SSDEQDHYLD | ALLSSQLALA | KMVCSDSPFA |
| 101 | 111 | 121 | 131 | 141 | 151 | 161 | 171 | 181 | 191 |
| GALRKRLLVL | QRVFYALSNK | YHDKGKVKQQ | QHSPESSSGS | ADVHSVSERP | RSSTDALIEM | GVRTGLSLLF | ALLRQSWMMP | VSGPGLSLCN | DVIHTAIEVV |
| 201 | 211 | 221 | 231 | 241 | 251 | 261 | 271 | 281 | 291 |
| SSLPPLSLAN | ESKIPPMGLD | CLSQVTTFLK | GVTIPNSGAD | TLGRRLASEL | LLGLAAQRGS | LRYLLEWIEM | ALGASAVVHT | MEKGKLLSSQ | EGMISFDCFM |
| 301 | 311 | 321 | 331 | 341 | 351 | 361 | 371 | 381 | 391 |
| TILMQMRRSL | GSSADRSQWR | EPTRTSDGLC | SLYEAALCLF | EEVCRMASDY | SRTCASPDSI | QTGDAPIVSE | TCEVYVWGSN | SSHQLVEGTQ | EKILQPKLAP |
| 401 | 411 | 421 | 431 | 441 | 451 | 461 | 471 | 481 | 491 |
| SFSDAQTIEA | GQYCTFVIST | DGSVRACGKG | SYGRLGLGDS | NNQSTLKKLT | FEPHRSIKKV | SSSKGSDGHT | LAFTTEGEVF | SWGDGDYGKL | GHGNSSTQKY |
| 501 | 511 | 521 | 531 | 541 | 551 | 561 | 571 | 581 | 591 |
| PKLIQGPLQG | KVVVCVSAGY | RHSAAVTEDG | ELYTWGEGDF | GRLGHGDSNS | RNIPTLVKDI | SNVGEVSCGS | SHTIALSKDG | RTVWSFGGGD | NGKLGHGDTN |
| 601 | 611 | 621 | 631 | 641 | 651 | 661 | 671 | 681 | 691 |
| RVYKPKVIEA | LQGMFIRKVC | AGSQSSLALT | STGQVYAWGC | GACLGCGSSE | ATALRPKLIE | ELAATRIVDV | SIGDSHCLAL | SHDNEVYAWG | NNSMGQCGQG |
| 701 | 711 | 721 | 731 | 741 | 751 | 761 | 771 | 781 | 791 |
| NSTGPITKPK | KVSGLDGIAI | QQISAGTSHS | LAWTALPRDR | QVVAWHRPYC | VDLEESTFSH | LRSFLERYCD | KINSEIPPLP | FPSSREHHSF | LKLCLKLLSN |
| 801 | 811 | 821 | 831 | 841 | 851 | 861 | 871 | 881 | 891 |
| HLALALAGGV | ATSILGRQAG | PLRNLLFRLM | DSTVPDEIQE | VVIETLSVGA | TMLLPPLRER | MELLHSLLPQ | GPDRWESLSK | GQRMQLDIIL | TSLQDHTHVA |
| 901 | 911 | 921 | 931 | 941 | 951 | 961 | 971 | 981 | 991 |
| SLLGYSSPSD | AADLSSVCTG | YGNLSDQPYG | TQSCHPDTHL | AEILMKTLLR | NLGFYTDQAF | GELEKNSDKF | LLGTSSSENS | QPAHLHELLC | SLQKQLLAFC |
| 1001 | 1011 | 1021 | 1031 | 1041 | 1051 | 1061 | 1071 | 1081 | 1091 |
| HINNISENSS | SVALLHKHLQ | LLLPHATDIY | SRSANLLKES | PWNGSVGEKL | RDVIYVSAAG | SMLCQIVNSL | LLLPVSVARP | LLSYLLDLLP | PLDCLNRLLP |
| 1101 | 1111 | 1121 | 1131 | 1141 | 1151 | 1161 | 1171 | 1181 | 1191 |
| AADLLEDQEL | QWPLHGGPEL | IDPAGLPLPQ | PAQSWVWLVD | LERTIALLIG | RCLGGMLQGS | PVSPEEQDTA | YWMKTPLFSD | GVEMDTPQLD | KCMSCLLEVA |
| 1201 | 1211 | 1221 | 1231 | 1241 | 1251 | 1261 | 1271 | 1281 | 1291 |
| LSGNEEQKPF | DYKLRPEIAV | YVDLALGCSK | EPARSLWISM | QDYAVSKDWD | SATLSNESLL | DTVSRFVLAA | LLKHTNLLSQ | ACGESRYQPG | KHLSEVYRCV |
| 1301 | 1311 | 1321 | 1331 | 1341 | 1351 | 1361 | 1371 | 1381 | 1391 |
| YKVRSRLLAC | KNLELIQTRS | SSRDRWISEN | QDSADVDPQE | HSFTRTIDEE | AEMEEQAERD | REEGHPEPED | EEEEREHEVM | TAGKIFQCFL | SAREVARSRD |
| 1401 | 1411 | 1421 | 1431 | 1441 | 1451 | 1461 | 1471 | 1481 | 1491 |
| RDRMNSGAGS | GARADDPPPQ | SQQERRVSTD | LPEGQDVYTA | ACNSVIHRCA | LLILGVSPVI | DELQKRREEG | QLQQPSTSAS | EGGGLMTRSE | SLTAESRLVH |
| 1501 | 1511 | 1521 | 1531 | 1541 | 1551 | 1561 | 1571 | 1581 | 1591 |
| TSPNYRLIKS | RSESDLSQPE | SDEEGYALSG | RRNVDLDLAA | SHRKRGPMHS | QLESLSDSWA | RLKHSRDWLC | NSSYSFESDF | DLTKSLGVHT | LIENVVSFVS |
| 1601 | 1611 | 1621 | 1631 | 1641 | 1651 | 1661 | 1671 | 1681 | 1691 |
| GDVGNAPGFK | EPEESMSTSP | QASIIAMEQQ | QLRAELRLEA | LHQILVLLSG | MEEKGSISLA | GSRLSSGFQS | STLLTSVRLQ | FLAGCFGLGT | VGHTGGKGES |
| 1701 | 1711 | 1721 | 1731 | 1741 | 1751 | 1761 | 1771 | 1781 | 1791 |
| GRLHHYQDGI | RAAKRNIQIE | IQVAVHKIYQ | QLSATLERAL | QANKHHIEAQ | QRLLLVTVFA | LSVHYQPVDV | SLAISTGLLN | VLSQLCGTDT | MLGQPLQLLP |
| 1801 | 1811 | 1821 | 1831 | 1841 | 1851 | 1861 | 1871 | 1881 | 1891 |
| KTGVSQLSTA | LKVASTRLLQ | ILAITTGTYA | DKLSPKVVQS | LLDLLCSQLK | NLLSQTGVLH | MASFGEGEQE | DGEEEEKKVD | SSGETEKKDF | RAALRKQHAA |
| 1901 | 1911 | 1921 | 1931 | 1941 | 1951 | 1961 | 1971 | 1981 | 1991 |
| ELHLGDFLVF | LRRVVSSKAI | QSKMASPKWT | EVLLNIASQK | CSSGIPLVGN | LRTRLLALHV | LEAVLPACES | GVEDDQMAQI | VERLFSLLSD | CMWETPIAQA |
| 2001 | 2011 | 2021 | 2031 | 2041 | 2051 | 2061 | 2071 | 2081 | 2091 |
| KHAIQIKEKE | QEIKLQKQGE | LEEEDENLPI | QEVSFDPEKA | QCCLVENGQI | LTHGSGGKGY | GLASTGVTSG | CYQWKFYIVK | ENRGNEGTCV | GVSRWPVHDF |
| 2101 | 2111 | 2121 | 2131 | 2141 | 2151 | 2161 | 2171 | 2181 | 2191 |
| NHRTTSDMWL | YRAYSGNLYH | NGEQTLTLSS | FTQGDFITCV | LDMEARTISF | GKNGEEPKLA | FEDVDAAELY | PCVMFYSSNP | GEKVKICDMQ | MRGTPRDLLP |
| 2201 | 2211 | 2221 | 2231 | 2241 | 2251 | 2261 | 2271 | 2281 | 2291 |
| GDPICSPVAA | VLAEATIQLI | RILHRTDRWT | YCINKKMMER | LHKIKICIKE | SGQKLKKSRS | VQSREENEMR | EEKESKEEEK | GKHTRHGLAD | LSELQLRTLC |
| 2301 | 2311 | 2321 | 2331 | 2341 | 2351 | 2361 | 2371 | 2381 | 2391 |
| IEVWPVLAVI | GGVDAGLRVG | GRCVHKQTGR | HATLLGVVKE | GSTSAKVQWD | EAEITISFPT | FWSPSDTPLY | NLEPCEPLPF | DVARFRGLTA | SVLLDLTYLT |
| 2401 | 2411 | 2421 | 2431 | 2441 | 2451 | 2461 | 2471 | 2481 | 2491 |
| GVHEDMGKQS | TKRHEKKHRH | ESEEKGDVEQ | KPESESALDM | RTGLTSDDVK | SQSTTSSKSE | NEIASFSLDP | TLPSVESQHQ | ITEGKRKNHE | HMSKNHDVAQ |
| 2501 | 2511 | 2521 | 2531 | 2541 | 2551 | 2561 | 2571 | 2581 | 2591 |
| SEIRAVQLSY | LYLGAMKSLS | ALLGCSKYAE | LLLIPKVLAE | NGHNSDCASS | PVVHEDVEMR | AALQFLMRHM | VKRAVMRSPI | KRALGLADLE | RAQAMIYKLV |
| 2601 | 2611 | 2621 | 2631 | 2641 | 2651 | 2661 | 2671 | 2681 | 2691 |
| VHGLLEDQFG | GKIKQEIDQQ | AEESDPAQQA | QTPVTTSPSA | SSTTSFMSSS | LEDTTTATTP | VTDTETVPAS | ESPGVMPLSL | LRQMFSSYPT | TTVLPTRRAQ |
| 2701 | 2711 | 2721 | 2731 | 2741 | 2751 | 2761 | 2771 | 2781 | 2791 |
| TPPISSLPTS | PSDEVGRRQS | LTSPDSQSAR | PANRTALSDP | SSRLSTSPPP | PAIAVPLLEM | GFSLRQIAKA | MEATGARGEA | DAQNITVLAM | WMIEHPGHED |
| 2801 | 2811 | 2821 | 2831 | 2841 | 2851 | 2861 | 2871 | 2881 | 2891 |
| EEEPQSGSTA | DSRPGAAVLG | SGGKSNDPCY | LQSPGDIPSA | DAAEMEEGFS | ESPDNLDHTE | NAASGSGPSA | RGRSAVTRRH | KFDLAARTLL | ARAAGLYRSV |
| 2901 | 2911 | 2921 | 2931 | 2941 | 2951 | 2961 | 2971 | 2981 | 2991 |
| QAHRNQSRRE | GISLQQDPGA | LYDFNLDEEL | EIDLDDEAME | AMFGQDLTSD | NDILGMWIPE | VLDWPTWHVC | ESEDREEVVV | CELCECSVVS | FNQHMKRNHP |
| 3001 | 3011 | 3021 | 3031 | 3041 | 3051 | 3061 | 3071 | 3081 | 3091 |
| GCGRSANRQG | YRSNGSYVDG | WFGGECGSGN | PYYLLCGTCR | EKYLAMKTKS | KSTSSERYKG | QAPDLIGKQD | SVYEEDWDML | DVDEDEKLTG | EEEFELLAGP |
| 3101 | 3111 | 3121 | 3131 | 3141 | 3151 | 3161 | 3171 | 3181 | 3191 |
| LGLNDRRIVP | EPVQFPDSDP | LGASVAMVTA | TNSMEETLMQ | IGCHGSVEKS | SSGRITLGEQ | AAALANPHDR | VVALRRVTAA | AQVLLARTMV | MRALSLLSVS |
| 3201 | 3211 | 3221 | 3231 | 3241 | 3251 | 3261 | 3271 | 3281 | 3291 |
| GSSCSLAAGL | ESLGLTDIRT | LVRLMCLAAA | GRAGLSTSPS | AMASTSERSR | GGHSKANKPI | SCLAYLSTAV | GCLASNAPSA | AKLLVQLCTQ | NLISAATGVN |
| 3301 | 3311 | 3321 | 3331 | 3341 | 3351 | 3361 | 3371 | 3381 | 3391 |
| LTTVDDSIQR | KFLPSFLRGI | AEENKLVTSP | NFVVTQALVA | LLADKGAKLR | PNYDKSEVEK | KGPLELANAL | AACCLSSRLS | SQHRQWAAQQ | LVRTLAAHDR |
| 3401 | 3411 | 3421 | 3431 | 3441 | 3451 | 3461 | 3471 | 3481 | 3491 |
| DNQTTLQTLA | DMGGDLRKCS | FIKLEAHQNR | VMTCVWCNKK | GLLATSGNDG | TIRVWNVTKK | QYSLQQTCVF | NRLEGDAEES | LGSPSDPSFS | PVSWSISGKY |
| 3501 | 3511 | 3521 | 3531 | 3541 | 3551 | 3561 | 3571 | 3581 | 3591 |
| LAGALEKMVN | IWQVNGGKGL | VDIQPHWVSA | LAWPEEGPAT | AWSGESPELL | LVGRMDGSLG | LIEVVDVSTM | HRRELEHCYR | KDVSVTCIAW | FSEDRPFAVG |
| 3601 | 3611 | 3621 | 3631 | 3641 | 3651 | 3661 | 3671 | 3681 | 3691 |
| YFDGKLLLGT | KEPLEKGGIV | LIDAHKDTLI | SMKWDPTGHI | LMTCAKEDSV | KLWGSISGCW | CCLHSLCHPS | IVNGIAWCRL | PGKGSKLQLL | MATGCQSGLV |
| 3701 | 3711 | 3721 | 3731 | 3741 | 3751 | 3761 | 3771 | 3781 | 3791 |
| CVWRIPQDTT | QTNVTSAEGW | WEQESNCQDG | YRKSSGAKCV | YQLRGHITPV | RTVAFSSDGL | ALVSGGLGGL | MNIWSLRDGS | VLQTVVIGSG | AIQTTVWIPE |
| 3801 | 3811 | 3821 | 3831 | 3841 | 3851 | 3861 | 3871 | 3881 | 3891 |
| VGVAACSNRS | KDVLVVNCTA | EWAAANHVLA | TCRTALKQQG | VLGLNMAPCM | RAFLERLPMM | LQEQYAYEKP | HVVCGDQLVH | SPYMQCLASL | AVGLHLDQLL |
| 3901 | 3911 | 3921 | 3931 | 3941 | 3951 | 3961 | 3971 | 3981 | 3991 |
| CNPPVPPHHQ | NCLPDPASWN | PNEWAWLECF | STTIKAAEAL | TNGAQFPESF | TVPDLEPVPE | DELVFLMDNS | KWINGMDEQI | MSWATSRPED | WHLGGKCDVY |
| 4001 | 4011 | 4021 | 4031 | 4041 | 4051 | 4061 | 4071 | 4081 | 4091 |
| LWGAGRHGQL | AEAGRNVMVP | AAAPSFSQAQ | QVICGQNCTF | VIQANGTVLA | CGEGSYGRLG | QGNSDDLHVL | TVISALQGFV | VTQLVTSCGS | DGHSMALTES |
| 4101 | 4111 | 4121 | 4131 | 4141 | 4151 | 4161 | 4171 | 4181 | 4191 |
| GEVFSWGDGD | YGKLGHGNSD | RQRRPRQIEA | LQGEEVVQMS | CGFKHSAVVT | SDGKLFTFGN | GDYGRLGLGN | TSNKKLPERV | TALEGYQIGQ | VACGLNHTLA |
| 4201 | 4211 | 4221 | 4231 | 4241 | 4251 | 4261 | 4271 | 4281 | 4291 |
| VSADGSMVWA | FGDGDYGKLG | LGNSTAKSSP | QKIDVLCGIG | IKKVACGTQF | SVALTKDGHV | YTFGQDRLIG | LPEGRARNHN | RPQQIPVLAG | VIIEDVAVGA |
| 4301 | 4311 | 4321 | 4331 | 4341 | 4351 | 4361 | 4371 | 4381 | 4391 |
| EHTLALASNG | DVYAWGSNSE | GQLGLGHTNH | VREPTLVTGL | QGKNVRQISA | GRCHSAAWTA | PPVPPRAPGV | SVPLQLGLPD | TVPPQYGALR | EVSIHTVRAR |
| 4401 | 4411 | 4421 | 4431 | 4441 | 4451 | 4461 | 4471 | 4481 | 4491 |
| LRLLYHFSDL | MYSSWRLLNL | SPNNQNSTSH | YNAGTWGIVQ | GQLRPLLAPR | VYTLPMVRSI | GKTMVQGKNY | GPQITVKRIS | TRGRKCKPIF | VQIARQVVKL |
| 4501 | 4511 | 4521 | 4531 | 4541 | 4551 | 4561 | 4571 | 4581 | 4591 |
| NASDLRLPSR | AWKVKLVGEG | ADDAGGVFDD | TITEMCQELE | TGIVDLLIPS | PNATAEVGYN | RDRFLFNPSA | CLDEHLMQFK | FLGILMGVAI | RTKKPLDLHL |
| 4601 | 4611 | 4621 | 4631 | 4641 | 4651 | 4661 | 4671 | 4681 | 4691 |
| APLVWKQLCC | VPLTLEDLEE | VDLLYVQTLN | SILHIEDSGI | TEESFHEMIP | LDSFVGQSAD | GKMVPIIPGG | NSIPLTFSNR | KEYVERAIEY | RLHEMDRQVA |
| 4701 | 4711 | 4721 | 4731 | 4741 | 4751 | 4761 | 4771 | 4781 | 4791 |
| AVREGMSWIV | PVPLLSLLTA | KQLEQMVCGM | PEISVEVLKK | VVRYREVDEQ | HQLVQWFWHT | LEEFSNEERV | LFMRFVSGRS | RLPANTADIS | QRFQIMKVDR |
| 4801 | 4811 | 4821 | 4831 | 4841 | 4851 | 4861 | |||
| PYDSLPTSQT | CFFQLRLPPY | SSQLVMAERL | RYAINNCRSI | DMDNYMLSRN | VDNAEGSDTD | Y |
| ID | Publication |
|---|---|
| 1 | Sun S, Shah P, Eshghi ST, Yang W, Trikannad N, Yang S, Chen L, Aiyetan P, Hoti N, Zhang Z, et al: Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides. Nat Biotech 2015, advance online publication. |
| 42 | Ma C, Zhao X, Han H, Tong W, Zhang Q, Qin P, Chang C, Peng B, Ying W, Qian X: N-linked glycoproteome profiling of human serum using tandem enrichment and multiple fraction concatenation. Electrophoresis 2013, 34:2440-2450. |